Correlation of Light Microscopic, Immunocytochemical and Ultrastructural Cytomorphology of Anaplastic Large Cell Ki-1 Lymphoma, an Activated Lymphocyte Phenotype

Papadimitriou, John C.; Abruzzo, Lynne V.; Bourquin, Patricia M.

doi:10.1159/000334022

Cited by 20 publications

(10 citation statements)

References 6 publications

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“…This T-type lymphoma in the oral cavity is an extremely rare disorder characterizing 1% of lymphomas overall [19]. From the scientific literature, we found around 15 cases of ALCL in the oral cavity [2, 6, 8, 11–17, 21, 22]. Only 5 cases of ALCL located in gingiva have been reported in the literature [12, 17, 22], and our case is the fourth reported occurrence of ALCL in the oral cavity of a HIV-seropositive patient [2, 11].…”

Section: Introductionmentioning

confidence: 99%

Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

Rozza-De-Menezes

Ferreira

Capella

et al. 2013

Case Reports in Dentistry

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This paper presents an unusual case of gingival ALCL, which mimicked a benign hyperplastic lesion that occurred in a 57-year-old white man representing the first clinical manifestation of acquired immunodeficiency syndrome (AIDS). The patient was referred to the Dental Clinic of PUCPR complaining of a lobulated nodule on the gingiva of his upper central incisors. The presence of advanced chronic periodontitis and dental plaque raised suspicion for a benignancy. An excisional biopsy was performed, and large pleomorphic cells with an abundant cytoplasm, sometimes containing prominent nucleoli and “Hallmark” cells, were observed through hematoxylin and eosin staining. The tumor cells showed strong CD30 expression, EMA, Ki-67, and LCA, and negative stain for p80NPM/ALK, CKAE1/AE3, CD20, CD3, CD56, and CD15. The final diagnosis was ALCL (ALK-negative). Further laboratory tests revealed positivity for human immunodeficiency virus (HIV). The patient was submitted to chemotherapy, but four months after diagnosis, the patient died due to pneumonia and respiratory failure. Oral anaplastic large-cell lymphoma (ALCL) is a rare disorder. Only 5 cases involving the gingiva have been reported, and to our knowledge, this is the first case reported of the ALCL, which mimicked a hyperplastic benignancy as the first clinical manifestation of AIDS.

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Section: Introductionmentioning

confidence: 99%

Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

Rozza-De-Menezes

Ferreira

Capella

et al. 2013

Case Reports in Dentistry

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“…and Akhtar et al. 13–18 and other reports in the literature lack the precise cytological descriptions and illustrations of the characteristic cells.…”

Section: Discussionmentioning

confidence: 91%

Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases

et al. 2010

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“…A search of the literature in the English language in PUBMED identified 11 prior cases of CD30 (+) ALCL involving the oral cavity [18][19][20][21][22][23][24][25][26][27] . In addition, several early cases were also reported as oral CD30+ ALCL but can be now reclassified into different categories of T-or B-cell lymphomas according to the most recent WHO classification of lymphoma [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

ALK negative anaplastic large cell lymphoma of the oral cavity showing spontaneous regression

et al. 2012

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Anaplastic large cell lymphoma is a subset of T-cell lymphoma which is rarely seen in the oral cavity. This entity may be either primary cutaneous or systemic and the prognosis varies significantly by subtype. In addition, several similar entities have been reported which may mimic this lesion both clinically and histologically. We present a case of anaplastic large cell lymphoma, ALK negative, on the mucosal aspect of the upper lip of an 88 year-old female with a history of cutaneous T-cell lymphoma which demonstrated spontaneous regression after biopsy. A brief review of the literature along with an overview of clinical behavior, histologic presentation, immunohistochemical analysis, genetics, and differential diagnosis of this subtype of anaplastic large cell lymphoma are presented.

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Correlation of Light Microscopic, Immunocytochemical and Ultrastructural Cytomorphology of Anaplastic Large Cell Ki-1 Lymphoma, an Activated Lymphocyte Phenotype

Cited by 20 publications

References 6 publications

Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature

Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases

ALK negative anaplastic large cell lymphoma of the oral cavity showing spontaneous regression

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