Correlation of bone mineral density and femoral neck hardness in bovine and human samples

Houde, John P.; Marchetti, Marina; Duquette, J; Hoffman, Allen H.; Steinberg, Gerald G.; Crane, Gilbert K.; Baran, Daniel T.

doi:10.1007/bf00310259

Cited by 21 publications

(9 citation statements)

References 20 publications

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“…Age-related changes in tissue hardness and tissue modulus of human bone do not generally occur at these length-scales when considering mean values of multiple indents within a sample (Boivin et al, 2008; Hoffler et al, 2000; Houde et al, 1995; Rho et al, 2002; Zioupos et al, 2008). These elastic properties at the micron length scale are sensitive to tissue age (e.g., higher values for interstitial than for osteonal tissue) (Hoffler et al, 2005; Rho et al, 1999) but not donor age.…”

Section: Discussionmentioning

confidence: 99%

Insights into reference point indentation involving human cortical bone: Sensitivity to tissue anisotropy and mechanical behavior

Granke

Coulmier

Uppuganti

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

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Reference point indentation (RPI) is a microindentation technique involving 20 cycles of loading in “force-control” that can directly assess a patient’s bone tissue properties. Even though preliminary clinical studies indicate a capability for fracture discrimination, little is known about what mechanical behavior the various RPI properties characterize and how these properties relate to traditional mechanical properties of bone. To address this, the present study investigated the sensitivity of RPI properties to anatomical location and tissue organization as well as examined to what extent RPI measurements explain the intrinsic mechanical properties of human cortical bone. Multiple indents with a target force of 10 N were done in 2 orthogonal directions (longitudinal and transverse) per quadrant (anterior, medial, posterior, and lateral) of the femoral mid-shaft acquired from 26 donors (25–101 years old). Additional RPI measurements were acquired for 3 orthogonal directions (medial only). Independent of age, most RPI properties did not vary among these locations, but they did exhibit transverse isotropy such that resistance to indentation is greater in the longitudinal (axial) direction than in the transverse direction (radial or circumferential). Next, beam specimens (~ 2 mm × 5 mm × 40 mm) were extracted from the medial cortex of femoral mid-shafts, acquired from 34 donors (21–99 years old). After monotonically loading the specimens in three-point bending to failure, RPI properties were acquired from an adjacent region outside the span. Indent direction was orthogonal to the bending axis. A significant inverse relationship was found between resistance to indentation and the apparent-level mechanical properties. Indentation distance increase (IDI) and a linear combination of IDI and the loading slope, averaged over cycles 3 through 20, provided the best explanation of the variance in ultimate stress (r2=0.25, p=0.003) and toughness (r2=0.35, p=0.004), respectively. With a transverse isotropic behavior akin to tissue hardness and modulus as determined by micro- and nano-indentation and a significant association with toughness, RPI properties are likely influenced by both elastic and plastic behavior of bone tissue.

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Section: Discussionmentioning

confidence: 99%

Insights into reference point indentation involving human cortical bone: Sensitivity to tissue anisotropy and mechanical behavior

Granke

Coulmier

Uppuganti

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

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“…However, tissue-level H and E from microindentation [30–34] and nanoindentation of cortical bone [34, 35] do not vary with donor age, though they do generally increase with tissue age [36, 37] or degree of mineralization (Table 1). As for in vivo microindentations of human tibia, the impact-derived BMSi was observed to increase with age (40 to 85 yo) when persons with and without fractures were included in the correlation [38].…”

Section: Independence Of Tissue-level Mechanical Properties From Donomentioning

confidence: 99%

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Nyman

Granke

Singleton

et al. 2016

Curr Osteoporos Rep

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Tissue-level mechanical properties characterize mechanical behavior independently of microscopic porosity. Specifically, quasi-static nanoindentation provides measurements of modulus (stiffness) and hardness (resistance to yielding) of tissue at the length scale of the lamella, while dynamic nanoindentation assesses time-dependent behavior in the form of storage modulus (stiffness), loss modulus (dampening), and loss factor (ratio of the two). While these properties are useful in establishing how a gene, signaling pathway, or disease of interest affects bone tissue, they generally do not vary with aging after skeletal maturation or with osteoporosis. Heterogeneity in tissue-level mechanical properties or in compositional properties may contribute to fracture risk, but a consensus on whether the contribution is negative or positive has not emerged. In vivo indentation of bone tissue is now possible, and the mechanical resistance to microindentation has the potential for improving fracture risk assessment, though determinants are currently unknown.

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“…The degree of bone mineralization has been described to be a decisive parameter for bone quality and stability [8,13,14]. Studies from the Norwegian national hip register suggest that regional bone loss might contribute to the risk of aseptic loosening [5,7].…”

Section: Introductionmentioning

confidence: 99%

Stress-related femoral cortical and cancellous bone density loss after collum femoris preserving uncemented total hip arthroplasty: a prospective 7-year follow-up with quantitative computed tomography

Kreß

Schmidt

Nowak

et al. 2012

Arch Orthop Trauma Surg

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Correlation of bone mineral density and femoral neck hardness in bovine and human samples

Cited by 21 publications

References 20 publications

Insights into reference point indentation involving human cortical bone: Sensitivity to tissue anisotropy and mechanical behavior

Insights into reference point indentation involving human cortical bone: Sensitivity to tissue anisotropy and mechanical behavior

Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk

Stress-related femoral cortical and cancellous bone density loss after collum femoris preserving uncemented total hip arthroplasty: a prospective 7-year follow-up with quantitative computed tomography

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