Correlation of Apparent Diffusion Coefficient With Ki-67 Proliferation Index in Grading Meningioma

Abstract

ADC values correlate inversely with Ki-67 proliferation index and help differentiate low-grade from aggressive meningiomas.

Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas

“…Determining the histopathological grades, types and proliferative activity of the meningiomas will help in pre-surgical planning, in predicting the prognosis and in the additional use of other therapies such as radiotherapy. [14][15][16][17] MRI is an important tool for the diagnosis, but conventional MRI techniques are limited in differentiating the low-grade and high-grade (atypical and anaplastic) meningiomas.…”

Whole‐tumor MRI histogram analyses of hepatocellular carcinoma: Correlations with Ki‐67 labeling index

“…Diffusion‐weighted imaging (DWI) is a functional MRI technique that can provide the information in terms of tissue cellularity . Previous studies have demonstrated that the apparent diffusion coefficient (ADC) value might be a potential biomarker predicting Ki‐67 LI in other tumors (including breast cancer, meningioma, bladder cancer, etc. ), as well as in HCC .…”

Prognostic Value of Ki-67 Labeling Index and Postoperative Radiotherapy in WHO Grade II Meningioma

“…Ginat et al 25 reported that maximum regional cerebral blood volume is correlated with Ki-67 LI in high-grade meningiomas. Tang et al 26 reported that apparent diffusion coefficient values, which are known to be related to tumor cellularity, correlate inversely with Ki-67 LI. This functional MRI could be used instead of Ki-67 LI to differentiate highly aggressive meningiomas before surgical resection.…”