Correlation in the densities of augmented and existing bone in guided bone augmentation

Yamada, Yutaka; Sato, Shuichi; Yagi, Hiroaki; Ujiie, Hisashi; Ezawa, Sanae; Ito, Koichi

doi:10.1111/j.1600-0501.2011.02204.x

Cited by 10 publications

(12 citation statements)

References 24 publications

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“…In complex clinical situations, it is unclear if it is possible to augment the bone beyond the bone surface, and this remains an aspect to be investigated. Some studies have shown that it is possible [ 27 , 28 ]. Those defects in which the membrane is not supported adequately by local bone walls, as in the sites for localized vertical augmentation of the bone crest are more difficult to reach.…”

Section: Discussionmentioning

confidence: 99%

Influence of Chromium-Cobalt-Molybdenum Alloy (ASTM F75) on Bone Ingrowth in an Experimental Animal Model

Zuchuat

Berli

Maldonado

et al. 2017

JFB

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Cr-Co-Mo (ASTM F75) alloy has been used in the medical environment, but its use as a rigid barrier membrane for supporting bone augmentation therapies has not been extensively investigated. In the present study, Cr-Co-Mo membranes of different heights were placed in New Zealand white, male rabbit tibiae to assess the quality and volume of new bone formation, without the use of additional factors. Animals were euthanized at 20, 30, 40, and 60 days. Bone formation was observed in all of the cases, although the tibiae implanted with the standard membranes reached an augmentation of bone volume that agreed with the density values over the timecourse. In all cases, plasmatic exudate was found under the membrane and in contact with the new bone. Histological analysis indicated the presence of a large number of chondroblasts adjacent to the inner membrane surface in the first stages, and osteoblasts and osteocytes were observed under them. The bone formation was appositional. The Cr-Co-Mo alloy provides a scaffold with an adequate microenvironment for vertical bone volume augmentation, and the physical dimensions and disposition of the membrane itself influence the new bone formation.

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Section: Discussionmentioning

confidence: 99%

Influence of Chromium-Cobalt-Molybdenum Alloy (ASTM F75) on Bone Ingrowth in an Experimental Animal Model

Zuchuat

Berli

Maldonado

et al. 2017

JFB

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“…Yamada et al [910] histologically studied rabbits with titanium caps on the calvarium. Histological observations confirmed the presence of trabecular bone, consisting of mineralized bone and an osteoid, bone marrow, and blood clots, in the occlusive space.…”

Section: Introductionmentioning

confidence: 99%

Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model

Kubota

Hasuike

Ozawa

et al. 2017

J Periodontal Implant Sci

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PurposeGuided bone regeneration (GBR) is the most widely used technique to regenerate and augment bones. Even though augmented bones (ABs) have been examined histologically in many studies, few studies have been conducted to examine the biological potential of these bones and the healing dynamics following their use. Moreover, whether the bone obtained from the GBR procedure possesses the same functions as the existing autogenous bone is uncertain. In particular, little attention has been paid to the regenerative ability of GBR bone. Therefore, the present study histologically evaluated the regenerative capacity of AB in the occlusive space of a rat guided bone augmentation (GBA) model.MethodsThe calvaria of 30 rats were exposed, and plastic caps were placed on the right of the calvaria in 10 of the 30 rats. After a 12-week healing phase, critical-sized calvarial bone defects (diameter: 5.0 mm) were trephined into the dorsal parietal bone on the left of the calvaria. Bone particles were harvested from the AB or the cortical bone (CB) using a bone scraper and transplanted into the critical defects.ResultsThe newly generated bone at the defects' edge was evaluated using micro-computed tomography (micro-CT) and histological sections. In the micro-CT analysis, the radiopacity in both the augmented and the CB groups remained high throughout the observational period. In the histological analysis, the closure rate of the CB was significantly higher than in the AB group. The numbers of cells positive for runt-related transcription factor 2 (Runx2) and tartrate-resistant acid phosphatase (TRAP) in the AB group were larger than in the CB group.ConclusionsThe regenerative capacity of AB in the occlusive space of the rat GBA model was confirmed. Within the limitations of this study, the regenerative ability of the AB particulate transplant was inferior to that of the CB particulate transplant.

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“…The periosteum placed on the plastic cap might be a good source of osteogenic precursor cells and growth factors. Many studies have examined the ability of mesenchymal stem cells (MSCs) in bone regeneration (11,12). Although MSC implantation has beneficial effects on bone regeneration, the survival of implanted MSCs is limited.…”

Section: Discussionmentioning

confidence: 99%

Influences of mechanical barrier permeability on guided bone augmentation in the rat calvarium

Yamamoto

Hasuike

Koshi

et al. 2018

Journal of Oral Science

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We used radiological and histological analyses to evaluate the effects of mechanical barrier permeability in a rat model of calvarial guided bone augmentation (GBA). The calvaria of 20 rats were exposed, and one of four types of plastic caps (an occlusive cylindrical plastic cap; a plastic cap with no top; a plastic cap with three holes; and a plastic cap with four holes) was randomly placed on both sides. Newly generated bone in the plastic caps was evaluated with micro-computed tomography (micro-CT) and histological analysis. Micro-CT volumetric analysis and decalcified hematoxylin and eosin-stained sections showed that GBA barrier permeability was inversely associated with the quantity of augmented bone obtained. Masson's trichrome staining showed that collagen in newly generated bony tissue was more mature in plastic caps with three holes than in those with more-permeable or more-occlusive barriers. Bone augmentation was inhibited in specimens exhibiting invasion of soft tissue through penetrating holes, and barrier permeability was associated with the quantity of augmented bone developed. In conclusion, moderate barrier permeability is optimal for development of mature augmented bone.

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Correlation in the densities of augmented and existing bone in guided bone augmentation

Cited by 10 publications

References 24 publications

Influence of Chromium-Cobalt-Molybdenum Alloy (ASTM F75) on Bone Ingrowth in an Experimental Animal Model

Influence of Chromium-Cobalt-Molybdenum Alloy (ASTM F75) on Bone Ingrowth in an Experimental Animal Model

Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model

Influences of mechanical barrier permeability on guided bone augmentation in the rat calvarium

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