Correlation between the menstrual cycle and the onset of recurrent aphthous stomatitis

Maheswaran, Thangadurai; Yamunadevi, Andamuthu; Ilayaraja, Vadivel; Dineshshankar, Janardhanam; Yoithapprabhunath, Thukanayakanpalayam Ragunathan; Ganapathy, N.

doi:10.4103/2229-3019.166117

Cited by 11 publications

(12 citation statements)

References 6 publications

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“…This finding is consistent with the results of other studies (Abdullah, ; Axéll & Henricsson, ). Hormonal changes during the menstruation cycle were posited as a probable mechanism for increased incidence of RAS among women (Maheswaran et al, ). However, a study by Rao and colleagues had discordant findings with regard to increased odds of RAS in women (Rao et al, ).…”

Section: Discussionmentioning

confidence: 99%

Depression symptoms and recurrent aphthous stomatitis—Evidence from a population‐based study in Indonesia

et al. 2020

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Objectives This study aims to report the prevalence and distribution of recurrent aphthous stomatitis (RAS) among Indonesian adults and to test the relationship between symptom of depression and RAS. Methods Data from the 2007 Indonesia Family Life Survey (IFLS 2007) were analysed to assess the association between symptom of depression and RAS. The prevalence of RAS in the previous month was self‐reported. Symptom of depression was measured using the 10‐item Center for Epidemiologic Studies Depression (CES‐D) scale. The distribution of RAS according to age, sex and level of stress was also presented in the bivariate analysis. Multivariable logistic regression models were fitted to test associations between symptom of depression and RAS, controlling for age, sex and the stress level. Results The previous month prevalence of RAS in Indonesian population was 12%. The adjusted odds ratios (ORs) from the logistic regression models indicate that, for each unit increase in the CES‐D depression score (range: 0–30), there was a 9% increase in the odds of having RAS (OR: 1.09, 95%CI: 1.08–1.10). Being older and being male was related with lower prevalence of RAS. Conclusions A higher score of depression was related to a higher prevalence of RAS. This association was persistent even after controlling for age, sex and the level of stress.

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Section: Discussionmentioning

confidence: 99%

Depression symptoms and recurrent aphthous stomatitis—Evidence from a population‐based study in Indonesia

et al. 2020

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“…Other studies carried out in the midst of the population of 18-year-old adolescents in Brazil discovered to be 24.9% [ 3 ], about 10.84% RAS were also discovered in Turkey [ 4 ], 14% was reported in the female dental students in King Khalid University Saudi Arabia [ 5 ], and 29.38% was reported in the college students in Beijing University of Chinese Medicine [ 6 ]. RAS is considered as a multifactorial process of unknown etiology, in which various triggering factors and an immunological disturbance are combined, including genetic [ 7 , 8 ], vitamin B-12, folate, and iron deficiency [ 9 , 10 ] and an allergic condition, such as atopy [ 11 , 12 ] Pain or unpleasant feeling and its recurrency in the oral cavity are always complained by an individual that has RAS, and this condition makes researchers interested in discovering the pathogenesis of RAS and its ultimate goal in finding the appropriate novel therapy [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients

Nur’aeny

Gurnida

Suwarsa

et al. 2021

International Journal of Dentistry

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Objective. To investigate the DNA methylation using pyrosequencing and its effects on the upregulation of IL6 mRNA in patients with recurrent aphthous stomatitis (RAS) in connection with hematinic deficiency and atopy. Material and Methods. This cross-sectional study was conducted at Dr. Hasan Sadikin Hospital, Bandung, from January–March 2019 and was approved by the Health Research Ethics Committee of Universitas Padjadjaran (Ethics No. 990/UN6.KEP/EC/2018). Furthermore, the subjects had RAS ulcers with a history of at least twice a year along with atopy and dietary imbalance with no history of recurrent intraoral herpes or any systemic diseases. This study was performed on 23 RAS patients and 21 healthy subjects, and the sampling was carried out consecutively. The blood samples were collected from all the subjects, and then, the DNA and RNA were extracted from the peripheral blood mononuclear cells (PBMCs). Consequently, the bisulfite-modified DNA was used to confirm the methylation status of the IL6 gene promoter through the pyrosequencing method. The methylation levels of the IL6 promoter were assessed by a reverse transcriptase-polymerase chain reaction technique. The gene expression of RAS and the control group was analyzed by the 2−ΔΔCT method. The statistical analysis using the Mann–Whitney U test was conducted to evaluate IL6 mRNA levels and DNA methylation with p value <0.05 considered to be statistically significant. Result. The IL6 mRNA levels were approximately 1.88-fold in RAS patients, and there was a significant relationship between the expression of the IL6 gene and the increased risk of RAS p < 0.001 . It was reported that four out of six sites in the cytosine phosphate guanine (CpG) island IL6 promoter had a lower degree of methylation, and two other sites in patients with RAS had greater methylation compared with control, but not statistically significant. Conclusion. This study showed the upregulation of IL6 mRNA levels in RAS patients compared to control. DNA methylation in the present study is at sites 566–658, whereas the location of the IL6 promoter is at sites 1–1684. Thus, it would be necessary conducting some research at other CpG sites of IL6 promoter islands to determine the status of DNA methylation.

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“…Previous studies have assessed the menstrual cycle and its hormonal changes in patients with RAS. Some studies reported more frequent RAS lesions in the luteal phase in which progesterone increment plays an important role [ 21 ]. In accordance to what they assumed, the results of this study showed more abnormality in the progesterone and testosterone level of patients with RAS in comparison with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the sex hormones’ serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study

et al. 2021

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Background In this study, we aimed to evaluate the sex hormonal serum level in patients with recurrent aphthous stomatitis and compare them with healthy participants. Methods This cross-sectional study was done on patients with recurrent aphthous stomatitis who had referred to Shiraz Dental Faculty, Oral and Maxillofacial Medicine Department during 2018–2019. The non -menopause women with recurrence of at least 3 lesions per year were enrolled in this study. The mean serum level of FSH, LH, PRL (prolactin), testosterone, DHT (Dihydrotestosterone), DHEA-S (Dehydroepiandrosterone sulfate), estradiol and progesterone of 30 participants in each group of case and control were measured and compared. The data were analyzed by SPSS version 18 and independent T-test, Mann–Whitney U test, Spearman’s correlation coefficient test, Chi-square test and Fisher’s test. Results The mean serum level of DHEA-S in patients with recurrent aphthous stomatitis (RAS) was significantly lower than the control group (p value = 0.02). In addition to DHEA-S, the mean serum level of testosterone was lower in the evaluation group although this difference was not significant (p value = 0.057). Considering the effect of age on the mean serum level of sex hormones, our results revealed that only DHEA-S mean serum level was decreased by increasing the age of participants in patients with RAS (p value = 0.018). The number of participants with abnormal range of testosterone (p value < 0.0001) and progesterone (p value = 0.037) serum level was significantly more in patients with RAS. The frequency of RAS in a year did not show a significant relationship with the serum level of the evaluated hormones. Conclusion The patients with RAS had a lower serum level of DHEA-S. The mean serum level of testosterone and progesterone was significantly abnormal in RAS patients.

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Correlation between the menstrual cycle and the onset of recurrent aphthous stomatitis

Cited by 11 publications

References 6 publications

Depression symptoms and recurrent aphthous stomatitis—Evidence from a population‐based study in Indonesia

Depression symptoms and recurrent aphthous stomatitis—Evidence from a population‐based study in Indonesia

The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients

Comparison of the sex hormones’ serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study

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