Correlation between synovial vascular endothelial growth factor, clinical, functional and radiological manifestations in knee osteoarthritis

Gaballah, Abdellatif; Hussein, Naglaa; Risk, Moustafa; Elsawy, Noha A; Elabasiry, Somaya

doi:10.1016/j.ejr.2015.01.002

Cited by 22 publications

(15 citation statements)

References 37 publications

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“…During later stages of OA in affected patients, VEGF expression has been found to be increased in the articular cartilage, synovium, synovial fluid, subchondral bone, and serum . Assessment of VEGF as a biomarker in patients with OA showed that increased synovial fluid VEGF is not only correlated with grade of OA severity but also with the degree of OA pain . A meta‐analysis of studies assessing VEGF expression in OA compared with non‐OA human joint tissue found significantly elevated levels of VEGF in OA tissue .…”

Section: Introductionmentioning

confidence: 99%

“…(13)(14)(15) However, there are also a number of well-known pathophysiologic effects of VEGF, including roles in tumor angiogenesis, rheumatoid arthritis (RA), psoriasis, atherosclerosis, brain edema, age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, and sepsis. (13,15) Aberrant VEGF Signaling in OA Tissues During later stages of OA in affected patients, VEGF expression has been found to be increased in the articular cartilage, (16)(17)(18)(19)(20)(21)(22)(23)(24) synovium, (25)(26)(27)(28)(29) synovial fluid, (30)(31)(32)(33)(34) subchondral bone, (35)(36)(37) and serum. (30,31,33,38) Assessment of VEGF as a biomarker in patients with OA showed that increased synovial fluid VEGF is not only correlated with grade of OA severity but also with the degree of OA pain.…”

Section: Introductionmentioning

confidence: 99%

“…(30,31,33,38) Assessment of VEGF as a biomarker in patients with OA showed that increased synovial fluid VEGF is not only correlated with grade of OA severity but also with the degree of OA pain. (34) A meta-analysis of studies assessing VEGF expression in OA compared with non-OA human joint tissue found significantly elevated levels of VEGF in OA tissue. (39) A meta-analysis of nine genome-wide association studies (GWAS), assessing 199 OA-related candidate genes, concluded that VEGF and one other candidate gene are significantly correlated with OA.…”

Section: Introductionmentioning

confidence: 99%

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Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

Hamilton

Nagao

Levine

et al. 2016

Journal of Bone and Mineral Research

192

188

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Increased vascular endothelial growth factor (VEGF) levels are associated with OA progression. Indeed, VEGF appears to be involved in OA specific pathologies including cartilage degeneration, osteophyte formation, subchondral bone cysts and sclerosis, synovitis, and pain. Moreover, a wide range of studies suggests that inhibition of VEGF signaling reduces OA progression. This review highlights both the potential significance of VEGF in OA pathology and pain as well as potential benefits of inhibition of VEGF and its receptors as an OA treatment. With the emergence of the clinical use of anti-VEGF therapy outside of OA, both as high dose systemic treatments and low dose local treatments, these particular therapies are now more widely understood. Currently, there is no established disease-modifying drug available for patients with OA, which warrants continued study of the inhibition of VEGF in OA, as standalone or adjuvant therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

Hamilton

Nagao

Levine

et al. 2016

Journal of Bone and Mineral Research

192

188

View full text Add to dashboard Cite

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“…Osteoarthritis diagnosis is based on both clinical and radiological disease assessments and X-ray is considered to be the gold standard used to confirm the diagnosis and is the main standard used in OA disease grading (24,25). The grading of OA is based on the radiological classification of the K-L score and is usually aided by other general or specific joint clinical and functional scores (26)(27).…”

Section: Discussionmentioning

confidence: 99%

Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

2017

Eur J Rheumatol

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“…This means that the mechanical factors alone do not explain the cause effect relationship between obesity and KOA [4]. In a previous study on Egyptian patients with KOA it was found that synovial vascular endothelial growth factor (VEGF) remarkably correlated with clinical manifestations, functional impact, as well as radiological changes [5]. In other studies, osteopontin served as a biochemical marker of disease severity in KOA [6] and obesity increased the risk of renal dysfunction [7] in Egyptian patients with KOA.…”

Section: Introductionmentioning

confidence: 96%

Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

Hussein

Sharara

2016

The Egyptian Rheumatologist

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Aim of the work: The aim of the present work was to correlate between serum level of leptin, matrix metalloproteinase-13 (MMP13), interleukin-1b (IL1b), tumour necrosis factor (TNFa), nitric oxide (NO) and functional impact in obese patients with knee osteoarthritis (KOA).Patients and methods: The study included 84 obese patients suffering from primary KOA. The knees were examined; pain assessed by visual analogue scale (VAS) and Lequesne's index for functional impact calculated. Serum leptin, MMP13, IL1b, TNF-a and NO were assessed.Results: The mean age of the patients was 54.64 ± 7.7 years. They were 72 females and 12 males (F:M = 6:1) with a mean BMI of 35.29 ± 4.8. Sixty patients had knee effusion which was bilateral in 54 (64.3%), unilateral in 6 (7.2%) while 24 (28.6%) did not have any effusion. Knee deformities were present in 60 (71.4%) patients. Female patients were only significantly higher than males regarding Lequesne's index (15.08 ± 4.4 vs 11 ± 3.4, p = 0.003). Patients with knee deformity had significantly higher VAS (9.12 ± 1.3 vs 6.96 ± 0.46, p = 0.001), IL1b (621.1 ± 98.8 vs 503.9 ± 74.6 pg/ml, p = 0.001), TNF-a (115.4 ± 29.1 vs 87.4 ± 4.4 pg/ml, p = 0.001), NO (67.32 ± 5.7 vs 59.2 ± 2.2 lmol/L, p = 0.001), MMP13 (33.98 ± 2.24 vs 30.1 ± 1.7 ng/ml, p = 0.012) and leptin (13.2 ± 1.6 vs 10.4 ± 0.6, p = 0.004) than those without. The VAS, Lequesne index, IL1b, TNF-a NO, MMP13 and leptin were significantly higher in patients with bilateral knee effusion (p < 0.0001 for all) compared to those with unilateral effusion or without. Leptin significantly correlated with BMI, VAS, Lequesne's index, IL1b, TNFa, NO and MMP13 (p < 0.0001 for all).Conclusion: Leptin plays a key role in obese patients with knee OA. It significantly correlates with knee pain, functional impairment, inflammatory cytokines and cartilage degradation.

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Correlation between synovial vascular endothelial growth factor, clinical, functional and radiological manifestations in knee osteoarthritis

Cited by 22 publications

References 37 publications

Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

Correlation between serum leptin, cytokines, cartilage degradation and functional impact in obese knee osteoarthritis patients

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