Correlation between stinging, TEWL and capacitance

Abstract

Our data indicate that there is certain relationship between the degree of stinging and the skin barrier. The stinging test method modified by lower concentration aqueous lactic acid and the assessment combined with PTEWL and PCAP is suitable for Chinese to evaluate the skin susceptibility.

What Is Sensitive Skin? A Systematic Literature Review of Objective Measurements

“…However, 66.7% of nonsensitive subjects also experience this reaction. Moreover, several studies have shown that sensitivity to one substance seems not to predict sensitivity to another [28,35,39], questioning the validity of the LAST as a reliable diagnostic test for sensitive skin.…”

“…In total, 11 studies focused on TEWL as a parameter of skin barrier function (table 1). Most studies observed higher TEWL in the unchallenged skin of subjects with sensitive skin compared to those with nonsensitive skin [20,41,48,49] and in stingers compared to nonstingers [39,40,41,50,51], while only 2 studies identified significantly higher TEWL in sensitive skin [40,41]. Moreover, higher TEWL at baseline seems to correlate with a stronger TEWL increase following provocation [40]: plastic occlusion resulted in a significantly longer evaporation half-life time in subjects with sensitive skin [49], and a trend to increased recovery time of TEWL following SLS stimulation was also observed [20].…”

“…Challenging the skin with octane or cumene, however, resulted in a significantly lower CAP in stingers compared to nonstingers [51]. A lower CAP at baseline predicted earlier onset of stinging and a weak correlation (Spearman's test: r = 0.307, p = 0.03), with a higher clinical stinging score identified [39]. On the other hand, other studies found no difference in CAP between stingers and nonstingers [40,50,51] or between subjects with sensitive and nonsensitive skin [20,48], either challenged or unchallenged [20,48,51].…”

Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy

“…In previous studies, the skin barrier function of SS subjects was predominantly analyzed at baseline or after stimulation using these macroscopic biophysical methods and significant differences between SS and NSS subjects could rarely be detected [13,14,16,18,20,26,49,50]. A range of limitations of these easy-to-use, rapid measurements are known [33], and our study demonstrates that more sensitive and specific tools for the in vivo analysis of the skin barrier in general and in SS in particular are needed.…”

Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment

“…Determining TEWL is useful in studying subjective irritation [9,75,76] . Trends toward higher baseline TEWL values measured on the nasolabial fold and cheek were reported in stingers compared to non-stingers.…”