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Background: The rise of multidrug-resistant tuberculosis (MDR-TB) has become a major public health concern around the world. Most patients with pulmonary tuberculosis have low body nutrients, hypocholesterolemia, and lower values were strongly associated with mortality in these patients. Representative data on lipid profile, fasting blood glucose abnormalities and their associated factors among MDR TB patients are lacking. Objective: To determine lipid profile, fasting blood glucose abnormalities and their associated factors among multi-drug resistant TB patients during therapy with anti-MDR-TB regimen in St.peter’s Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods and materials: A cross-sectional study was conducted among multi-drug resistant TB patients during MDR therapy regimen in St. Peter’s Specialized Hospital in Addis Ababa, Ethiopia from January to November 2020.Using the Consecutive sampling method a total of 162 blood samples was collected in SST tubes and analyzed by using the Cobas chemistry analyzer. Data were analyzed using SPSS software version 23 packages. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study participants. Other associations were performed with Pearson’s correlation coefficient. A p-value of <0.05 at the 95 % confidence level were considered as statistically significant in all the analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of diabetes was 16%. Out of those who had diabetes (9.8%) was newly diagnosed and 6.2% already knew their diabetes status.The most common serum lipid profile abnormalities were 92.6 % HDL-C and 35.8% had TG levels above the borderline. Among MDR-TB patients, 25.9% had a fasting blood glucose level that was higher than normal (hyperglycemic). Conclusion: Lipid profile abnormalities and an increased risk of diabetes have been observed in patients with multidrug-resistant tuberculosis. Factors associated with abnormal blood glucose needed attention to avoid further complications and also the finding of this research calls for the implementation of active case finding of DM in patients diagnosed for MDR-TB.
Background: The rise of multidrug-resistant tuberculosis (MDR-TB) has become a major public health concern around the world. Most patients with pulmonary tuberculosis have low body nutrients, hypocholesterolemia, and lower values were strongly associated with mortality in these patients. Representative data on lipid profile, fasting blood glucose abnormalities and their associated factors among MDR TB patients are lacking. Objective: To determine lipid profile, fasting blood glucose abnormalities and their associated factors among multi-drug resistant TB patients during therapy with anti-MDR-TB regimen in St.peter’s Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods and materials: A cross-sectional study was conducted among multi-drug resistant TB patients during MDR therapy regimen in St. Peter’s Specialized Hospital in Addis Ababa, Ethiopia from January to November 2020.Using the Consecutive sampling method a total of 162 blood samples was collected in SST tubes and analyzed by using the Cobas chemistry analyzer. Data were analyzed using SPSS software version 23 packages. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study participants. Other associations were performed with Pearson’s correlation coefficient. A p-value of <0.05 at the 95 % confidence level were considered as statistically significant in all the analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of diabetes was 16%. Out of those who had diabetes (9.8%) was newly diagnosed and 6.2% already knew their diabetes status.The most common serum lipid profile abnormalities were 92.6 % HDL-C and 35.8% had TG levels above the borderline. Among MDR-TB patients, 25.9% had a fasting blood glucose level that was higher than normal (hyperglycemic). Conclusion: Lipid profile abnormalities and an increased risk of diabetes have been observed in patients with multidrug-resistant tuberculosis. Factors associated with abnormal blood glucose needed attention to avoid further complications and also the finding of this research calls for the implementation of active case finding of DM in patients diagnosed for MDR-TB.
Background: Mycobacterium tuberculosis causes tuberculosis (TB), an infectious lung disease. There is mounting evidence linking low lipid levels to a variety of human diseases, including TB. Cholesterol, mainly due to its involvement in heart disease, gets more attention in recent years. The objectives of the study were to look into the link that connects hypolipidemia to the existence of pulmonary/extrapulmonary TB; we have tried to find the link in relation to patients who have been recently diagnosed with TB as well as in those who are having TB in the long term. Materials and methods: An observational study was performed on TB patients attending respiratory medicine at the Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India, from February 2021 to January 2022, and their lipid levels were tested from patients with consent and correlated. Student's t-test was applied to the obtained data. To convey quantitative data, measurements such as mean along with standard deviation were applied, and a p-value of 0.05 was considered statistically significant. Results: This research included 80 subjects, 40 of whom were diagnosed with TB, and the rest (40 controls) were deemed healthy. The age group with the highest low lipid levels in pulmonary TB was 40-50 years. A chi-square test of association was conducted; this test revealed that the fraction of TB patients having lower than normal levels of total cholesterol (p = 0.0001), triglyceride level (p = 0.006), high-density lipoprotein (p = 0.009), low-density lipoprotein (p = 0.006), and body mass index (p = 0.000) was statistically significantly higher in contrast to the control group. Thus, there was a significant correlation between a higher prevalence of hypolipidemia in patients with pulmonary tuberculosis (PTB) and normal healthy individuals. Conclusions: We observed a strong relationship between hypolipidemia and TB, indicating that patients with low lipid levels tend to have severe inflammation as compared to patients with normal lipid levels.
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