Correlation between serum lactadherin and pulse wave velocity and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus

Cheng, Mei; Li, Baoying; Li, Xiaoli; Wang, Qian; Zhang, Jianhua; Jing, Xue‐Jiao; Gao, Haiqing

doi:10.1016/j.diabres.2011.09.030

Cited by 45 publications

(44 citation statements)

References 22 publications

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“…The gene for MFGE8 is in a region linked with susceptibility to obesity and eating behaviors in humans (37,38). Additionally, circulating Mfge8 concentrations correlate with the degree of hemoglobin glycosylation and are elevated in diabetics, a disease with markedly increased prevalence in obese subjects (39,40). The work presented here identifies Mfge8 and the αvβ3 and αvβ5 integrins as a key pathway regulating enterocyte processing of dietary fats.…”

Section: Discussionmentioning

confidence: 91%

Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity

Khalifeh-Soltani¹,

Dk²,

Ha³

et al. 2016

JCI Insight

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Section: Discussionmentioning

confidence: 91%

Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity

Khalifeh-Soltani¹,

Dk²,

Ha³

et al. 2016

JCI Insight

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“…Jin ' s study addressed an association of increased glycated albumin (GA), C-reactive protein (hsCRP) and soluble intercellular adhesion mole cule (sICAM-1) levels with diffuse coronary artery disease (CAD) in patients with T2DM (7) . Wang et al (8) and Cheng et al (9) suggested that monocytes chemotactic protein (MCP-1) was associated with T2DM. However, the mechanism of this phenomenon is still not clearly understood.…”

Section: Introductionmentioning

confidence: 98%

Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus

Zhang

et al. 2012

Journal of Pediatric Endocrinology and Metabolism

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Association analysis shown that the level of sICAM-1, VCAM-1, MCP-1 and vWF elevated in CHD with T2DM patients. Vascular endothelial dysfunction could be caused to the coronary artery stenosis pathophysiological process. Results from this study suggested that sICAM-1, VCAM-1, MCP-1 and vWF may contribute to the occurrence and development of vascular lesions in T2DM. These endothelial function related factors could be acceptable as a prediction and testing index of vascular complications in T2DM.

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“…In mouse models of obesity, Mfge8 expression is markedly induced in white adipose tissue after weight gain 21 . Further, circulating Mfge8 concentrations are elevated in patients with diabetes 22,23 and correlate with the extent of hemoglobin glycosylation 23 .…”

mentioning

confidence: 97%

Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids

Khalifeh-Soltani

McKleroy

Sakuma

et al. 2014

Nat Med

117

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Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human obesity and in mice on a high-fat diet, but its role in obesity is unknown. We show here that Mfge8 promotes the absorption of dietary triglycerides and the cellular uptake of fatty acid and that Mfge8-deficient (Mfge8−/−) mice are protected from diet-induced obesity, steatohepatitis and insulin resistance. Mechanistically, we found that Mfge8 coordinates fatty acid uptake through αvβ3 integrin– and αvβ5 integrin–dependent phosphorylation of Akt by phosphatidylinositide-3 kinase and mTOR complex 2, leading to translocation of Cd36 and Fatp1 from cytoplasmic vesicles to the cell surface. Collectively, our results imply a role for Mfge8 in regulating the absorption and storage of dietary fats, as well as in the development of obesity and its complications.

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Correlation between serum lactadherin and pulse wave velocity and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus

Cited by 45 publications

References 22 publications

Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity

Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity

Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus

Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids

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