Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus

Li, Quanmin; Zhang, Zhifang; Du, Ruiqin; Hu, Xiaoqiang; Yan, Yan; Gao, Qing; Fan, Yanting

doi:10.1515/jpem-2012-0159

Cited by 6 publications

(5 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the use of circulating vWF levels to evaluate endothelial function is feasible, effective and practical. The present investigation confirmed that plasma vWF levels were higher in patients with stable CAD than those in controls, which is consistent with previous studies [ 32 – 34 ]. This hypothesis is supported by previous findings indicating that makers for endothelial dysfunction are valuable predictors of the presence and severity of CAD [ 33 ].…”

Section: Discussionsupporting

confidence: 93%

Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease

Jin

Chen

Wang

et al. 2018

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundBrain-derived neurotrophic factor (BDNF) is a neurotrophin involved in angiogenesis and maintenance of endothelial integrity. Whether circulating BDNF levels are associated with von Willebrand factor (vWF) levels, which are indicators of endothelial dysfunction is not known. This study investigated the association between plasma BNDF and vWF levels and whether these biomarkers could predict cardiovascular events at a 12-month follow-up in patients with stable coronary artery disease (CAD).MethodsWe recruited 234 patients with suspected angina pectoris. Subjects were divided into CAD (n = 143) and control (n = 91) groups based on coronary angiography. Plasma BDNF and vWF levels were measured using ELISA. Patients were followed-up for one year, and information on adverse cardiac events was collected.ResultsCAD patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. High vWF levels were associated with low BDNF levels even after adjustment for age, gender, low-density lipoprotein (LDL) levels, and the presence of diabetes mellitus. A receiver operating characteristic curve was used to determine whether low BDNF and high vWF levels could predict adverse cardiovascular events. The area under the curve for vWF and the inverse of BDNF were 0.774 and 0.804, respectively.ConclusionsThese findings suggest that endothelial dysfunction is an important determinant of the impaired circulating BDNF levels, and they further reflected cardiovascular prognosis in stable CAD patients.

show abstract

Section: Discussionsupporting

confidence: 93%

Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease

Jin

Chen

Wang

et al. 2018

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“… 18 In our study, we discovered that lnc‐NEAT1 expression was positively associated with Gensini score, which represented more advanced disease severity. The reason might be that: through modulating miR‐181d‐5p/cyclin‐dependent kinase inhibitor 3 (miR‐181d‐5p/CDKN3) axis, lnc‐NEAT1 increased the proliferation of HUVECs, 20 which could contribute to coronary artery stenosis and pathophysiological process in CHD, 21 thus resulting in unfavorable disease severity. Furthermore, a study reveals that elevation of TC is closely correlated with coronary artery stenosis.…”

Section: Discussionmentioning

confidence: 99%

“…through modulating miR-181d-5p/cyclin-dependent kinase inhibitor 3 (miR-181d-5p/CDKN3) axis, lnc-NEAT1 increased the proliferation of HUVECs, 20 which could contribute to coronary artery stenosis and pathophysiological process in CHD, 21 thus resulting in unfavorable disease severity. Furthermore, a study reveals that elevation of TC is closely correlated with coronary artery stenosis.…”

Section: Discussionmentioning

confidence: 99%

LncRNA NEAT1 correlates with Th17 cells and proinflammatory cytokines, also reflects stenosis degree and cholesterol level in coronary heart disease patients

Zhu

Lin

Chen

2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Long non‐coding RNA nuclear enriched abundant transcript 1 (lnc‐NEAT1) regulates endothelial cell functions, CD4 + T cell regulation and chronic inflammation related to coronary heart disease (CHD). Then this case‐control study measured lnc‐NEAT1 expression in CHD patients, aiming to explore its clinical value in CHD management. Methods Totally, 120 documented CHD patients and 120 suspected subjects without CHD diagnosis as controls were enrolled. Plasma lnc‐NEAT1 was detected by RT‐qPCR in all participants, plasma inflammatory cytokines were assessed by ELISA, T helper (Th) 1, Th2, Th 17 cell proportions in CD4 + T cells were analyzed by flow cytometric analysis in CHD patients, respectively. Results Lnc‐NEAT1 was higher in CHD patients than in controls ( p < 0.001). In CHD patients, lnc‐NEAT1 positively associated with Gensini score ( r = 0.323, p < 0.001). Besides, lnc‐NEAT1 positively correlated with tumor necrosis factor‐α ( r = 0.271, p = 0.003), interleukin (IL)‐1β ( r = 0.216, p = 0.018), IL‐6 ( r = 0.217, p = 0.018) and IL‐17 ( r = 0.292, p = 0.001); meanwhile, it was positively associated with the percentage of Th 17 cells ( r = 0.384, p = 0.002). However, no correlation was found in lnc‐NEAT1 with the percentage of Th1 or Th2 cells (all p > 0.05). Moreover, lnc‐NEAT1 was correlated with higher hyperuricemia prevalence ( p = 0.028), increased total cholesterol ( r = 0.263, p = 0.004) and low‐density lipoprotein cholesterol ( r = 0.261, p = 0.004), but was not associated with other characteristics (all p > 0.05). Conclusion Lnc‐NEAT1 correlates with Th17 cells and proinflammatory cytokines, also reflects stenosis degree and cholesterol level in CHD patients, which potentially improves the management of CHD patients.

show abstract

“…This study revealed the relationship of homozygous variants of Q448E and rs2073932 with increased vWF activity which was consistent with our previous study. [ 14 ] To date, some studies have shown that vWF was positively correlated with Gensini score[ 25 ] and vascular endothelial growth factor,[ 26 ] which associated with increased atherosclerosis progression. [ 27 ] Therefore, the association between ADAMTS13 polymorphisms and vWF activity may in turn support their roles in promoting atherosclerosis progression in type 2 DM individuals.…”

Section: Discussionmentioning

confidence: 99%

Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus

et al. 2018

View full text Add to dashboard Cite

Background:The imbalance of von Willebrand factor (vWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13) has been associated with atherosclerosis progression. A high level of vWF which regulates thrombus formation is associated with diabetes mellitus (DM), and some ADAMTS13 and vWF polymorphisms have effects on their levels. Therefore, this study aimed to evaluate the associations of ADAMTS13 and vWF polymorphisms and their levels with DM and severity of coronary stenosis.Materials and Methods:Eighty-seven DM and 84 control individuals were recruited. vWF and ADAMTS13 activities as well as vWF antigen were measured by collagen-binding assay (CBA), residual-CBA, and in-house enzyme-linked immunosorbent assay, respectively. ADAMTS13 and vWF polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism.Results:The E and G alleles and AA genotype of ADAMTS13 Q448E, rs2073932, and rs652600, respectively, were independently associated with DM (odds ratio [OR] [95% confidence interval (CI)] = 2.5 [1.1, 5.6], 2.3 [1.0, 5.2], and 4.7 [1.2, 18.6], respectively). Moreover, E allele and AA genotype of Q448E and rs652600 were also significantly associated with multi-vessel disease (OR [95% CI] = 2.2 [1.0, 4.8] and 3.2 [1.0, 10.0], respectively), while the E and G allele of Q448E and rs2073932 were associated with high Gensini score (OR [95% CI] = 2.3 [1.1, 4.9] and 2.3 [1.1, 5.1], respectively).Conclusion:Association of ADAMTS13 polymorphisms with DM, number of vessel stenosis, and Gensini score may indicate the possible contribution of ADAMTS13 polymorphisms to atherosclerosis progression and severity of coronary stenosis in DM.

show abstract

Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus

Cited by 6 publications

References 5 publications

Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease

Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease

LncRNA NEAT1 correlates with Th17 cells and proinflammatory cytokines, also reflects stenosis degree and cholesterol level in coronary heart disease patients

Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus

Contact Info

Product

Resources

About