Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke

High Plasma D-Dimer Indicates Unfavorable Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis

“…Although the mechanism of association between higher D-dimer levels and unfavorable outcome in acute stroke patients after thrombolysis remains uncertain, higher D-dimer levels may be related to several factors. First, Park et al [13] demonstrated the positive correlation between levels of D-dimer and infarction volume in patients with AIS. Second, increased D-dimer is an indicator of systemic hypercoagulability and therefore reflects the presence of coagulopathy or ongoing thrombus formation systemically or within cerebral vessels [14] .…”

The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

“…High D-dimer levels have been reported in the acute phase of stroke [4]. Elevated D-dimer level has also been shown to relate to early clinical progression [5], stroke subtypes [6], and infarction volume [7]. Some studies have suggested that D-dimer can be seen as an outcome predictor in ischemic stroke and an indicator of severity of traumatic brain injury [8].…”

Study on Plasma D-Dimer for Early Diagnosis of Ischemic Stroke

“…These findings are also similar with a study from a medical university from Japan 30 . Although the volumetric measurement of CT scan of the brain and Plasma D-Dimer value correlated on admission but the D-Dimer value was insignificant with the stroke volume at 7 days after stroke 16 . In this study the average CT volume of lesion was 19.95±4.92 cm 3 and Plasma D-Dimer measured within 33.49±28.71 hours after the event of stroke.…”

“…On the other hand, Alvarez-Perez and Montaner, in their separate study found significant correlation of plasma D-Dimer with a mean value ranging from 500-218 hg/ml in different subtypes with the lowest concentration in atherothrombotic group 14,25 . Park et al, found mean plasma D-Dimer level on admission as 215.3 hg/ml in patients with focal infarction and 385.7 hg/ml in patients with multiple embolic infarctions 16 . He also observed that plasma D-Dimer value was 566 hg/ml in patients with 1-19 cc infarctions, 668 hg/ml in patients with 20-49 cc infarctions, 702 hg/ml in 50-199 cc infarctions, 844 hg/ml in >200 cc infarctions 16 .…”

“…Park et al, found mean plasma D-Dimer level on admission as 215.3 hg/ml in patients with focal infarction and 385.7 hg/ml in patients with multiple embolic infarctions 16 . He also observed that plasma D-Dimer value was 566 hg/ml in patients with 1-19 cc infarctions, 668 hg/ml in patients with 20-49 cc infarctions, 702 hg/ml in 50-199 cc infarctions, 844 hg/ml in >200 cc infarctions 16 . These findings are also similar with a study from a medical university from Japan 30 .…”