The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

Melake, Mostafa Saleh; El-Kabany, Rasha A; Alemam, Aktham Ismail; El-Shereef, Ahmed Mohamed; Okda, Mohamed

doi:10.14740/jnr362w

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…As regards CRP as a biomarker for diagnosis of CES, we found that CRP level was higher in non-CES patients but without any significant difference between CES and non-CES patients ( Table 1). This is in agreement with Alvarez-Perez and colleagues [25] and Melake and colleagues [26]. They found that CRP levels were higher among the atherosclerotic group compared with those of CES, and this difference possesed a highly statistical significant effect, and contributed these results to the higher degree of inflammation in atherosclerotic stroke subtype.…”

Section: Discussionsupporting

confidence: 89%

Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

Mohamed

ElGawad

ELmotayam

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: The brain is a productive source of a variety of enzymes and any brain injury like a stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum. Evaluation of these enzymes represents a simple method for the ischemic stroke subtype diagnosis and prognosis. Objective: This study aimed to determine the role of brain natriuretic peptide (BNP), D-dimer, creatine-kinase-MB (CK-MB), C-reactive protein (CRP) serum levels, and globulin/albumin ratio in the diagnosis of CES stroke and its ability to predict short-term outcome. Methods: This study was conducted on 96 patients with acute ischemic stroke, subdivided into two groups: group Ι was 48 patients with cardio-embolic stroke and group ΙΙ was 48 patients with non-cardio-embolic. All patients were subjected to the assessment of serum BNP, D-dimer and CK-MB, and CRP and globulin/albumin ratio within the first 24 h of stroke. In the third week, they were assessed by mRS. Results: The mean levels of BNP, D-dimer level, and CK-MB were significantly higher in patients with cardio-embolic stroke than in patients with non-cardio-embolic stroke (P < 0.001) and also were associated with poor short-term outcome. Conclusion: Elevated plasma levels of BNP, D-dimer levels, and CK-MB can be used as surrogate biomarkers for the diagnosis of cardio-embolic stroke and prediction of poor short-term outcomes.

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Section: Discussionsupporting

confidence: 89%

Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

Mohamed

ElGawad

ELmotayam

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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“…Suppression of the inflammatory mediators have been shown to limit injury [10]. Increased inflammatory biomark-ers (D-dimer, C-Reactive Protein and Fibrinogen) have been shown to increase stroke severity and disability within 30 days [11], while erythrocyte sedimentation rate has not been shown to predict the outcome of stroke [12]. Chest imaging of COVID-19 patients show consolidation, ground glass opacities and bilateral lung involvement, which were consistent with findings in our patient [1,6,7].…”

Section: Discussionmentioning

confidence: 99%

“…These levels are directly proportional to the clinical outcome and mortality. Procalcitonin levels are normal unless there is a concomitant bacterial infection [1,6,7,11].…”

Section: Discussionmentioning

confidence: 99%

Intravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report

Laxamana

et al. 2020

Journal of Clinical Neuroscience

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“…Another study published in the same year evaluated the role of DD, FIB, and CRP as plasma biomarkers in acute ischemic stroke. It proved that these biomarkers might be helpful in detecting the etiology of acute cerebral vascular stroke [16]. A study released in 2016 evaluated CRP, FIB, and DD in patients with progressive cerebral infarction.…”

Section: Discussionmentioning

confidence: 99%

Level of fibrinogen, D-dimers and C-reactive protein, and correlations between these parameters in ischemic and haemorrhagic stroke

Warpechowski¹,

Jamiołkowska²,

Ilnicki³

et al. 2021

Med Og Nauk Zdr.

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Introduction and objective. Fibrinogen (FIB) and C-reactive protein (CRP) play an important role in any inflammatory response. FIB levels may be higher in stroke patients compared to non-stroke patients. CRP is used to detect inflammation due to its high sensitivity in aseptic inflammation. Blood levels of d--dimer (DD) are used to determine the amount of fibrin formed and distributed. Inflammation may play an important role in the pathogenesis of haemorrhagic stroke causing primal damage, and in ischemic stroke causing secondary damage due to a decrease in perfusion in the brain. The aim of the study is to prove the hypothesis that the inflammatory process is involved in the pathogenesis of ischemic and haemorrhagic stroke. Materials and method. The study used data from a retrospective study conducted on a group of 402 stroke patients, among which the levels of FIB, CRP and DD were compared. The patients were hospitalized in the Department of Neurology of the Medical University (MU) in Białystok from 1 January -31 December 2016. Patients' data was obtained from medical records. The diagnosis of stroke was confirmed by CT of the head. Patients with other brain injuries were excluded from the study. The study was approved by the Bioethics Committee of the MU of Bialystok. The applied research method was the statistical method. Results. A positive moderate correlation was found between CRP and FIB. In the group of patients with ischemic stroke it was higher (0.59) than in the group of patients with haemorrhagic stroke(0.22). Moreover, in the group of patients with ischemic stroke, a correlation was found between DD and CRP(0.517). Conclusions.Inflammatory process is involved in pathogenesis of ischemic and haemorrhagic stroke, but could be associated with comorbid diseases. Increased CRP correlates with higher levels of FIB and DD in the ischemic stroke but not in the haemorrhagic stroke.

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The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

Cited by 9 publications

References 25 publications

Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

Intravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report

Level of fibrinogen, D-dimers and C-reactive protein, and correlations between these parameters in ischemic and haemorrhagic stroke

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