Correlation between prostate specific antigen levels and various prostatic pathologies

Banerjee, Bedarshi; Iqbal, Banyameen; Kumar, Harsh; Kambale, Tushar; Bavikar, Rupali

doi:10.4103/0972-4958.191184

Cited by 3 publications

(7 citation statements)

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“…10 Benerjee B et al also showed that BPH, BPH with prostatitis and only prostatitis were seen in 38.8%, 28.75% and 7.5% cases respectively and all these benign cases had PSA range of 0-7 ng/ml. 1 Similarly other studies also showed that PSA level is usually < 20 ng/ ml in case of benign conditions like BPH. 12,13 Prostatic intraepithelial neoplasia was seen in 5.9 % cases in our study and all the cases were HGPIN with PSA level <10ng/ml.…”

Section: Discussionmentioning

confidence: 84%

“…This correlates with several studies. 1,2,4,6 Maximum number of patients were in age group 70 -79 years followed by 60-69 years. This finding was similar to studies done in different parts of India.…”

Section: Discussionmentioning

confidence: 99%

“…This finding was similar to studies done in different parts of India. 1,2,6 A study done in Kathmandu valley showed that the maximum number of patients with prostatic disease was seen in 61-70 years age group. 10 There were 36 cases (70.6%) of BPH with maximum number of cases in age group 60-69 years.…”

Section: Discussionmentioning

confidence: 99%

“…Enlargement of prostate gland causes urinary symptoms. 1 Increased PSA levels is found to be closely associated with prostate cancer. Other reasons for increased PSA could be benign prostatic hyperplasia (BPH), prostatitis or prostatic trauma.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences. Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings. Results: A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml. Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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“…В то же время в ранее проведенных исследованиях отмечена связь ýкспрессии ERα с показателем Глисона при максимальной ýкспрессии рецептора в высокодифференцированных опухолях [22]. В настоящее время уровень ПСА не всегда отражает тяжесть патологических изменений и, в том числе, не может прогнозировать характер течение заболевания и его исход [23,24]. В проведенном исследовании показано, что повышение уровня ПСА коррелировало с ростом ýкспрессии AR, снижением ýкспрессии ERβ и TRIM16 (рис.…”

Section: Discussionunclassified

TRIM16 transcription factor in prostate cancer

et al. 2018

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Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology

Mainali¹,

Nepal²,

Chaudhary³

et al. 2018

Nep. Med. J.

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Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.

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Correlation between prostate specific antigen levels and various prostatic pathologies

Cited by 3 publications

References 1 publication

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

TRIM16 transcription factor in prostate cancer

Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology

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