Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology

Mainali, Nirajan; Nepal, Niraj; Chaudhary, Prabesh; Shrestha, Jit

doi:10.3126/nmj.v1i2.21579

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its concentration is also increased in BPH (benign prostatic hyperplasia), PIN (prostatic intra-epithelial neoplasia) and prostatitis. 3 Concentration above 4 ng/ml is considered abnormal. Prostate cancer prevention trial (PCPT) study, which included biopsy regardless of PSA level, demonstrated that there is no level of PSA below which prostate cancer risk falls to zero.…”

Section: Introductionmentioning

confidence: 99%

Triad of serum PSA, DRE and biopsy in diagnosing prostatic diseases- How useful it is?

Akhtar,

Saba,

Khan

et al. 2023

JDPO

View full text Add to dashboard Cite

Prostate specific antigen (PSA) is a glycoprotein produced by prostatic acini and prostatic tissue. Its concentration increases in prostatic diseases. Concentration above 4 ng/ml is considered abnormal but there is no clear-cut point between normal and abnormal PSA levels. PSA is considered as serum marker for prostatic cancer but it is organ specific, not cancer specific. Digital rectal examination (DRE) is a routine part of prostate cancer screening. Biopsies are performed when PSA test and DRE are abnormal. The study is an attempt for comparative analysis among serum PSA, age, DRE, and biopsy results for the institution of specific treatment at an early stage. Study was performed on 200 patients with different prostatic lesions in the Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh. Clinical, DRE, PSA and histopathological biopsy were performed and analyzed by correlating the data. In our study 77.5% had normal (0-4 ng/ml) PSA level and 13.5% had >10 ng/ml PSA levels. BPH was the most common diagnosis (54.0%), followed by prostatitis (20.0%), BPH with prostatitis in 16.0% and carcinoma (10.0%). Serum PSA with positive DRE ranged from 1.2 ng/ml to 56 ng/ml while in negative DRE ranged from 0.18 ng/ml to 9.6 ng/ml. PSA is specific for prostate but not for prostatic diseases. With increasing age serum PSA also increases. Conjunction of serum PSA with other variables like age, DRE and biopsy makes a better diagnosis of prostatic diseases.

show abstract

Section: Introductionmentioning

confidence: 99%