Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention

Yu, Rong; R, Hou; Wang, Tong; Li, Tianliang; Han, Huijuan; An, Jian

doi:10.12669/pjms.37.3.3469

Cited by 7 publications

(12 citation statements)

References 16 publications

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“…[ 18 , 20 ] Subgroup analysis according to sample size, and follow-up showed pooled HR estimates with similar results to that of the original analysis. Interestingly, STEMI patients (HR = 2.66, 95% CI 1.62–4.35, P < .001) [ 14 , 19 ] with high MHR tend to have a higher risk of developing long-term MACEs than ACS patients (HR = 1.41, 95% CI 1.15–1.73, P = .001). [ 13 , 17 , 18 , 20 ] The subgroup analysis results of HR values for long-term MACEs were shown in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…These studies were all observation researches and were conducted in China, [15,[17][18][19][20] and Turkey. [13,14,16,21] One study included CAD patients, [15] 3 studies included ST-segment elevation myocardial infarction (STEMI) patients, [14,16,19] and 5 studies ACS patients. [13,17,18,20,21]…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…All of the end points selected were analyzed by COX proportional hazard model, and we chose the HR and 95% CI of the adjusted analyses. These studies were all observation researches and were conducted in China, [15,[17][18][19][20] and Turkey. [13,14,16,21] One study included CAD patients, [15] 3 studies included ST-segment elevation myocardial infarction (STEMI) patients, [14,16,19] and 5 studies ACS patients.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…2). [13][14][15][17][18][19][20] Besides, the pooled result of 5 studies including 6270 patients found that the high MHR value was associated with higher long-term mortality (HR = 1.71, 95% CI 1.10-2.66, P = .017, Fig. 3).…”

Section: Incidence Of Long-term Mortality/macesmentioning

confidence: 99%

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Monocyte to high-density lipoprotein ratio predict long-term clinical outcomes in patients with coronary heart disease: A meta-analysis of 9 studies

et al. 2022

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Background: A novel inflammation-related biomarker, the monocyte to high-density lipoprotein cholesterol ratio (MHR), had a great relation to the development and prognosis of coronary atherosclerotic heart disease. Current study was to investigate whether the MHR was a potential tool in predicting the mortality and major adverse cardiac events (MACEs) in patients suffering coronary heart disease (CHD) by meta-analysis.Methods: The Cochrane Library, PubMed, MEDLINE, Scopus, EMBASE, and Web of science were searched for relevant cohort studies published prior to February 10, 2022. The association between MHR and mortality/MACEs was analyzed in patients with CHD. Hazard ratios (HR) with 95% confidence interval (CI) were calculated to estimate the strength of association.Results: In the meta-analysis, a total of 9 studies of 11,345 patients with CHD were included. Compared with the low level of MHR group, the high MHR value was associated with higher long-term MACEs (HR = 1.72 95% CI 1.36-2.18, P < .001), long-term mortality (HR = 1.71, 95% CI 1.10-2.66, P = .017), and in-hospital mortality/MACEs (HR = 2.82, 95% CI = 1.07-7.41, P = .036).Conclusions: This study suggested that increased MHR value might be associated with higher long-term mortality and longterm MACEs in CHD patients. MHR might serve as a potential prognostic indicator for risk stratification in patients with CHD.Abbreviations: CAD = coronary artery disease, CHD = coronary heart disease, CI = confidence interval, HDL = High-density lipoprotein, HDL-C = HDL-cholesterol, HR = Hazard ratios, MACEs = major adverse cardiac events, MHR = monocyte to highdensity lipoprotein cholesterol ratio, NOS = New Castle-Ottawa scale, PRISMA = preferred reporting items for systematic reviews and meta-analyses, STEMI = ST-segment elevation myocardial infarction.

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Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Incidence Of Long-term Mortality/macesmentioning

confidence: 99%

See 2 more Smart Citations

Monocyte to high-density lipoprotein ratio predict long-term clinical outcomes in patients with coronary heart disease: A meta-analysis of 9 studies

et al. 2022

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“…MHR has been shown to be associated with many diseases, including acute ischemic Stroke (AIS), primary nephrotic syndrome (NS) and Parkinson's disease (PD) [16][17][18]. Meanwhile, a recent cross-sectional study has found that MHR is associated with the incidence of NAFLD [19], and that MHR is associated with a variety of cardiovascular events and has been shown to be positively associated with adverse cardiovascular outcomes [20,21]. However, data on the relationship between MHR and CAD risk in NAFLD patients are not yet available.…”

Section: Introductionmentioning

confidence: 99%

The monocyte to high-density lipoprotein cholesterol ratio is positively associated with the severity of coronary artery disease in patients with nonalcoholic fatty liver disease

Zhang

Wang

Zhao

et al. 2022

Preprint

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Background Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease. Inflammation and dyslipidemia have been demonstrated to show excellent influence in atherosclerosis in patients with NAFLD. Monocyte (MON) and high-density lipoprotein cholesterol (HDL-C) ratio (MHR), one of the inflammation markers, is associated with the occurrence and severity of NAFLD. However, evidence of MHR in the risk of coronary artery disease (CAD) among NAFLD patients is limited. Methods We conducted a retrospective study of 612 patients with ultrasonogram-confirmed NAFLD who underwent percutaneous coronary intervention (PCI). All patients were divided into NAFLD + CAD group and NAFLD + non-CAD group. For univariate analysis between the two groups, continuous variables were compared using independent samples t-test or Mann-Whitney test, and categorical variables were compared using chi-square test or Fisher Exact tests. In addition, we used binary logistic regression analysis to identify risk and protective factors associated with CAD, constructed receiver operating characteristic (ROC) curves to assess the predictive value of MHR for CAD, and methodological studies of chi-square test for trend analysis the distribution of Gensini scores in MHR at different levels, and the risk degree of Gensini scores at different MHR levels by ordinal logistic regression. Results The study included a total of 336 CAD patients and 277 non-CAD patients. Univariate analysis showed that CAD patients had higher MHR than non-CAD patients (P < 0.001). Meanwhile, compared with pure NAFLD patients, multivariate logistic regression analysis showed that MHR remained to be an independent risk factor for CAD after adjusting for confounding risk factors (OR = 15.57, 95% CI 4.68–51.85, P < 0.001). At the same time, it was superior to traditional lipid parameters. NHR, NLR, and TG were also independent risk factors for CAD. HDL-C is a protective factor for CAD among NAFLD patients. The ROC curve showed that MHR or other inflammatory markers combined with traditional risk factors can improve the ability to predict CAD. In further study, trend chi-square showed that higher levels of MHR predicted more severe coronary lesions (P < 0.05). Multivariate ordinal logistic regression analysis showed that MHR was independently associated with changes in Gensini score (OR = 2.95, 95% CI 1.78–4.89, P < 0.001). Conclusion The MHR was positively associated with CAD risk among NAFLD patients and reflected coronary atherosclerosis severity.

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Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

Guo

2022

Coronary Artery Disease

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Coronary artery disease (CAD) is the leading cause of death worldwide. Inflammation and atherosclerotic plaques are the primary pathological mechanisms of CAD. Upon stimulation by deposited lipids and damaged endothelium, innate and adaptive immune cells are activated and recruited to initiate plaque development. Therefore, inflammatory cells and mediators are used to identify inflammatory risk in CAD patients. HDL-cholesterol (HDL-C) is demonstrated to have anti-inflammatory roles in atherosclerosis by interfering with plasma membrane lipid rafts of immune cells. Based on this, novel inflammatory parameters such as monocyte to HDL-C ratio are explored to improve the risk estimation of CAD prognosis. Moreover, with the advance in treatment strategies targeting the inflammatory process in atherosclerosis, identifying CAD patients with increased inflammatory risk by novel inflammatory parameters is of great importance in guiding CAD management.Therefore, this review aims to summarize the current information regarding inflammatory activation and HDL-C in atherosclerosis with a particular focus on the clinical implication of the novel HDL-C-related inflammatory parameters in CAD.

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Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention

Cited by 7 publications

References 16 publications

Monocyte to high-density lipoprotein ratio predict long-term clinical outcomes in patients with coronary heart disease: A meta-analysis of 9 studies

Monocyte to high-density lipoprotein ratio predict long-term clinical outcomes in patients with coronary heart disease: A meta-analysis of 9 studies

The monocyte to high-density lipoprotein cholesterol ratio is positively associated with the severity of coronary artery disease in patients with nonalcoholic fatty liver disease

Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol–related inflammatory parameters as predictors

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