Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus

A comparison of effect of Iron Deficiency Anemia on HbA1c levels in controlled diabetics and non-diabetics: A cross sectional analysis of 300 cases

“…[13] [ Table 6] Also Saudek et al suggested that red cell age was unlikely to be a significant factor in explaining the changes in HbA 1 C levels during the treatment of IDA and believed that the reported differences in HbA 1 C concentrations before and after iron supplementation were due to differences in the laboratory methods used for mea suring HbA 1 C. [24] Ferritin is a storage form of iron, and it reflects the true iron status [WHO]. In our study, serum ferritin as well as serum iron level was indirectly proportional to HbA 1 C. As explained previously, in IDA, ferritin is decreased with increase in the red cell life span which is associated with increased HbA 1 C. This goes in hand with other study results of Shanthi et al and Raj et al [15,25] We also analyzed HbA 1 c results in different degrees of anemia and found that HbA 1 C level increases as severity…”

The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review

“…Ferritin as a marker of iron status is useful if it is low but would not rule out iron deficiency if it was found to be normal or elevated as ferritin is an acute phase reactant and inflammation may mask a true low ferritin. Raj and Rajan [26] investigated 86 patients with type 2 diabetes mellitus and demonstrated that serum ferritin positively correlated with HbA 1c and was increased with increasing duration of disease, indicating that poor glycaemic control can contribute to elevated ferritin levels independent of iron status. In situations of increased inflammation, alternative measures of iron status such as TSAT or total iron binding capacity should be considered.…”

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

“…Arul Senghor et al, 2012 showed that serum ferritin in diabetic patients is significantly higher and correlates with increased duration of diabetes. Similar Study by Raj S et al, 2013 showed that Serum ferritin, a reflector of body iron stores was markedly high in diabetic patients compared to controls and this significantly increased with increasing duration of diabetes (17). Also According to studies by Pramiladevi et al, 2013 serum ferritin was increased in diabetic patients as compared to controls (12).…”