A comparison of effect of Iron Deficiency Anemia on HbA1c levels in controlled diabetics and non-diabetics: A cross sectional analysis of 300 cases

Rajagopal, Lavanya; Sundaram, Arunachalam; Ganapathy, Shivashekar; Ramraj, Balaji; Raja, Veena

doi:10.21276/apalm.1276

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…9 Multiple studies had been conducted out to investigate consequence on HbA1c levels of Iron Deficiency Anemia in patient with diabetes and non-diabetic individuals, while some of the studies was conducted for comparing HbA1c variation in both these groups. 10 The US National Health and Nutrition Survey found IDA has been linked with alterations in HbA1c ranges from <5.0 to ≥5.5% and strongly rises in the patients of absolute HbA1c levels 2 months after treatment of anemia. 11,12 Similarly, Chinese Health and Nutrition Survey reported iron deficiency alone or IDA had an increased in subjects with prediabetes using HbA1c alone when compared with using both HbA1c and fasting blood glucose as the diagnostic criteria.…”

Section: Introductionmentioning

confidence: 99%

Effect of anemia on HbA1c level in subjects with normal glucose tolerance.

Saeed¹,

Siddiqui²,

Fawwad³

et al. 2021

TPMJ

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Objective: To evaluate the effect of iron deficiency anemia (IDA) on HbA1c levels in non-diabetic Pakistani individuals. Study Design: Observational Study. Setting: Baqai Institute of Diabetology and Endocrinology, Baqai Medical University Karachi. Period: March 2019 to May 2019. Material & Methods: After approval by the ethics committee of BMU. A world Health Organization (WHO) criterion was used for screening normal glucose tolerance. Subject with type 1 and 2 diabetes, and gestational diabetes were excluded. Selected subjects were categorized into 2 groups (anemic and non-anemic). Data was collected on a structured questionnaire. Result: Out of 139 subjects, 72 were males and 67, were females. Anemia was more common in males as compared to females (34.7% vs 19.4%). Among males, HbA1c level was found higher in anemic subjects with MCV<76fl than anemic subjects with MCV>76fl and subjects without anemia. While in females, HbA1c level was similar in both anemic and non-anemic subjects. Conclusion: HbA1c as a diagnostic marker should be assessed carefully as the presence of IDA can lead to falsely elevated HbA1c levels in non-diabetic subjects.

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Section: Introductionmentioning

confidence: 99%

Effect of anemia on HbA1c level in subjects with normal glucose tolerance.

Saeed¹,

Siddiqui²,

Fawwad³

et al. 2021

TPMJ

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show abstract

“…10 Furthermore, the prevalence of anemia in diabetics is twice as high as in non-diabetics. 11 In fact, the authors in 12 confirmed the association between IDA and A1 levels and the study 13 has also demonstrated this relationship by measuring HbA1c values in nondiabetic patients with iron deficiency (Measurements are taken before and after iron treatment) Finally, the etiology of obese people's hypoferremia still unclear and an iron-poor diet could be suggested as a factor even if there is no advanced research done to establish the link between serum iron and dietary iron intake in obese adults. 14 Obesity is considered as a chronic inflammation-mediated, the iron chelation in the reticuloendothelial system can result in hypoferremia despite adequate or even increased iron stores which plays a role in this disorder.…”

Section: Introductionmentioning

confidence: 99%

Association between BMI and Iron Status among Diabetic Patients in Oujda-ANGAD-MOROCCO

Hsaini

Aboussaleh

Bikri

et al. 2020

Curr Res Nutr Food Sci

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Nowadays, Public health concern on obesity and anemia has become very important disease in the world. Objective: In this study, we aim to examine the relationship between the overweight of diabetic patients from the Oujda-Angad region and their body iron status. Methods: A total of 114 patients aged between 18 and 70 years old. The patients were from the regional referral Center of Oujda-Angad. All patients had type 2 diabetes. They attended the centre between December the 1st, 2016 and May the 30th, 2018 and were diagnosed previously for more than 6 months. The patients were participated in this study after they have provided a written consent. Demographic and biochemical data were collected. Results: The mean ferritin concentration was between 19.14 µg /mL± and 21.32 µg / mL± and the mean Serum iron level was around 105.05µg/dl. Moreover, 34.5% of diabetic patients were overweight according to WHO Standars (BMI ≥ 25 kg/m2) while around 31% of were obese (BMI ≥ 30 kg/m2). The correlation coefficient of linear regression was positive for BMI/Plasma Ferritin and negative for BMI/hemoglobin, and BMI/Serum iron. Furthermore, the CRP concentration was less than 6mg/l for 90% of obese and overweight patients. As conclusion, we can confirm that patients having an iron deficiency are not overweight or obese. Furthermore, overweight and obesity could be a risk factor of iron deficiency in diabetic patients.

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The Effect of Iron Replacement Therapy on HbA1c Levels in Diabetic and Nondiabetic Patients: A Systematic Review and Meta-Analysis

AlQarni,

Alghamdi,

Aljubran

et al. 2023

JCM

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Background: Several studies have reported that iron-deficiency anemia (IDA) and its treatment might lead to a distorted reading of glycated hemoglobin (HbA1c) value. Hence, this review aims to systematically investigate the effect of iron replacement therapy (IRT) on HbA1c levels, as the literature is deficient in assessing this clinical phenomenon. Methods: An electronic search of the Cochrane, MEDLINE, and Embase databases was conducted by four independent authors. Results: Among the 8332 articles identified using the search strategy, 10 records (with a total of 2113 participants) met the inclusion criteria and were analyzed. In nine of the studies, IRT was found to decrease HbA1c levels; in the remaining study, IRT was found to increase HbA1c levels. The effect size of the pooled standardized mean difference in HbA1c levels between the treatment and control groups with IDA was 1.8 (95% CI = −0.5, 2.31). Heterogeneity was assessed using the I2 and χ2 tests, and the resultant values were 98.46% and p = 0.09, respectively. Additionally, the mean difference between the HbA1c levels (pre-IRT and post-IRT) showed a drop in the HbA1c levels which ranged from 1.20 to 0.43 mg/dL. Conclusions: The results suggest that IRT decreases HbA1c levels, and it is helpful in treating IDA patients with poor glycemic control. Accordingly, the results provide an added perspective on antidiabetic medication dosing and physicians’ interpretation of initially elevated HbA1c values.

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A comparison of effect of Iron Deficiency Anemia on HbA1c levels in controlled diabetics and non-diabetics: A cross sectional analysis of 300 cases

Cited by 3 publications

References 20 publications

Effect of anemia on HbA1c level in subjects with normal glucose tolerance.

Effect of anemia on HbA1c level in subjects with normal glucose tolerance.

Association between BMI and Iron Status among Diabetic Patients in Oujda-ANGAD-MOROCCO

The Effect of Iron Replacement Therapy on HbA1c Levels in Diabetic and Nondiabetic Patients: A Systematic Review and Meta-Analysis

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