Correlation between body temperature, blood pressure and plasmatic nitric oxide in septic patients

Abstract

Objective to investigate whether there is a relationship between plasmatic levels of nitrate, body temperature, and blood pressure values in patients with sepsis, severe sepsis and septic shock. Method prospective observational study performed in a Brazilian hospital; data were collected from July to December 2009. Thirty blood samples were obtained from a total of 29 patients. Blood samples (10ml) were collected for subsequent laboratory analysis to determine nitrate levels in the plasma. Results nitric oxide synthesis is increased in patients with septic shock, and is inversely correlated to the body temperature values. Conclusion these data show that the measurement of body temperature and the observation of hypothermic conditions in septic patients could be important to guide the nursing regarding the evolution of individuals with sepsis to septic shock.

Validation of a care protocol for the septic patient in the Intensive Care Unit

“…For the elaboration of the care protocol, the scientific literature (3,(6)(7)(8)(9)(10) and the guidelines of the Surviving Sepsis Campaign (1) were searched using the following descriptors: Sepsis; Nursing; Intensive Care Unit; Validation Studies; Clinical Protocols, initially creating a protocol consisting of three main topics with 18 items: Topic 1 -Screening for sepsis and recognition of clinical manifestations (item 1); Topic 2 -Initial resuscitation package (control of the first six hours) (items 2-12); Topic 3 -Support treatment (items [13][14][15][16][17][18].…”

Implantação do Protocolo de Manejo de Sepse no Pronto Atendimento do Hospital Universitário Regional dos Campos Gerais

“…No presente estudo, a maioria dos pacientes apresentaram hipotermia, condição que ocorre normalmente no estado crítico de sepse, e acredita-se que agrava significativamente o prognóstico do paciente, uma vez que indica a dificuldade do organismo em continuar sua luta contra o agressor. 17 No que concerne a contagem de leucócitos, 70% dos pacientes apresentaram valores elevados, condição recorrente da desordem inflamatória e atividade celular intensa, indicativo de que existe um processo inflamatório e infeccioso. 5 Se esta condução estiver presente com outros critérios de SIRS são necessárias medidas Tabela 2.…”

“…Alto:>12.000mm 3 ou presença de >10% de formas jovens) e plaquetas (Baixo:<100000mm 3 ; Adequado:≥100000 mm 3 ), elevação da creatinina (Sim:>1,10 mg/dL; Não: 0,60≤1,10 mg/dL ), acidose metabólica (Sim: déficit de bases<5mE/L e lacta-to>1,5 vezes do valor normal; Não: pH = 7,4), bilirrubina (Sim:>2 vezes o valor de referência; Não: bilirrubina total até 1,2 mg/dL e bilirrubina direta 0,4 mg/dL). [2][3][4]6,7,17 Os dados foram analisados de forma descritiva por meio de frequência absoluta e relativa, média e desvio padrão no programa Excel.…”

The Effects of Naoxintong Capsule on the Vascular Endothelial Function and Inflammatory Factors in Spontaneously Hypertensive Rats

“…Serum NO levels were obtained by measuring the serum concentrations of its stable end-products nitrite (NO 2 -) and nitrate (NO 3 -), as described previously [16].…”