Correlates of Type 2 diabetes mellitus in children, adolescents and young adults in north India: a multisite collaborative case‐control study

Vikram, Naval K.; Tandon, Nikhil; Misra, Anoop; Srivastava, M. C.; Pandey, Ravindra Mohan; Mithal, Ambrish; Sharma, Satendra; Ajmani, Ajay K.; Madhu, Sri Venkata; Batra, C. M.; Gupta, Nidhi

doi:10.1111/j.1464-5491.2005.01782.x

Cited by 51 publications

(25 citation statements)

References 26 publications

(24 reference statements)

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“…Amongst the metabolic parameters, FBG showed an increase in both adolescent girls (3.5 mg/ dl, p = 0.04) and boys (0.5 mg/dl, p = NS). These data support our previous observations of increasing occurrence of type 2 diabetes mellitus in young obese children, particularly those with a high W-HR [22] .…”

Section: Discussionsupporting

confidence: 82%

Secular Trends in Obesity, Regional Adiposity and Metabolic Parameters among Asian Indian Adolescents in North India: A Comparative Data Analysis of Two Selective Samples 5 Years Apart (2003, 2008)

Singhal

Misra²,

Shah³

et al. 2010

Ann Nutr Metab

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Aim: To assess and compare the secular trends in anthropometric and biochemical parameters over 5 years (2003–2008) amongst Asian Indian adolescents in north India. Methods: Adolescents matched for age, gender, socioeconomic strata and school grade were taken from two school-based studies (2003, n = 106, girls = 50 and boys = 56; 2008, n = 134, girls = 59 and boys = 75) in north India. Assessment included anthropometric measures [body mass index (BMI), waist circumference (WC), waist to hip ratio (W-HR), and triceps skinfold thickness] and biochemical parameters [fasting blood glucose (FBG), serum triglycerides and high-density lipoprotein cholesterol (HDL-c)]. Results: A significant increase in WC (7.2 cm, p < 0.0001), W-HR (0.8, p < 0.0001), triceps skinfold thickness (6.5 mm; p = 0.0001) and FBG (3.5 mg/dl, p = 0.04) was noted in girls, while a significant decrease was noted for HDL-c (–4.6 mg/dl, p = 0.0002) in boys. A higher increase was noted for BMI, WC and FBG in girls as compared to boys. Over 5 years, a marked increase in prevalence (%) of obesity was seen, as indicated by the >95th percentile for age and gender-specific cutoffs of BMI: 11.5% (girls), WC: 19% (girls) and triceps skinfold thickness: 11.7% (girls), 8.8% (boys). Conclusion: Over the last 5 years, there has been a significant increase in abdominal obesity and FBG and a decrease in HDL-c amongst Asian Indian adolescents from north India, which puts them at risk for metabolic disorders at an early age. In view of these data, primary prevention strategies for childhood obesity need to be strengthened.

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Section: Discussionsupporting

confidence: 82%

Secular Trends in Obesity, Regional Adiposity and Metabolic Parameters among Asian Indian Adolescents in North India: A Comparative Data Analysis of Two Selective Samples 5 Years Apart (2003, 2008)

Singhal

Misra²,

Shah³

et al. 2010

Ann Nutr Metab

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“…Similar studies done by Vikram et al in New Delhi showed a significant increase in TGs and high waist to hip ratio in young adults with family history of Type 2 DM [12].…”

Section: Discussionsupporting

confidence: 71%

“Study of Total Cholesterol (Tc), Triacylglycerols (Tg), High Density Lipoprotein Cholesterol (Hdl-C) in Type Ii Diabetes Mellitus.”

Patil¹,

Mandare²,

Pandurang³

2017

Asian J Pharm Clin Res

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Objective: There are probably 100 million people in the world with diabetes mellitus (DM), and incidences of diabetes are on the rise. Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardiovascular disorders. The aim of this study is to investigate the total cholesterol (TC), triacylglycerols (TGs), high-density lipoprotein cholesterol (HDL-C) in Type 2 DM, and healthy controls. Methods:The study was conducted on 50 controls and 50 Type 2 diabetic subjects between age group of 30 and 60 years. Serum TC was determined by an enzymatic (cholesterol oxidase/phenol-aminophenazone [PAP]) colorimetric method and TGs were determined by an enzymatic (glycerol phosphate oxidase-PAP) method, and HDL-C was estimated by a precipitant method. Statistical analysis was done using unpaired t-test. Results:The mean value of TC, TGs, and HDL-C in normal subjects is 165.5±24.24, 118.7±41.58, 28.38±7.85 mg/dl, respectively, and the value of TC, TGs, and HDL-C in diabetic patients is 179±31.69, 164.35±27.93, 25.4±6.86 mg/dl, respectively. The observed difference in the means of TC, TGs, and HDL-C in normal and diabetic are statistically significant (p<0.05). Conclusion:From the present study, it is concluded that TC, TGs, and HDL-C levels for all persons with Type 2 DM should be done as a routine test. Furthermore, early diagnosis and treatment of dyslipidemia can be used as a preventive measure for the development of cardiovascular disease in Type 2 diabetes.

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“…Most of countries in the Middle East such as Kuwait, Saudi Arabia, Qatar, Bahrain and the United Arab Emirates are the world's leaders in term of T2DM prevalence [60] . In both developed and developing countries diabetes is the main cause of NAFLD, and also the prevalence of NAFLD is higher in people with diabetes than in non-diabetic [61] (Table 2: Provides the 2013 IDF statistics for diabetes prevalence in Asian countries).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Non-alcohol fatty liver disease in Asia: Prevention and planning

Ashtari

Pourhoseingholi

Zali

2015

WJH

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AIM:To review all of epidemiological aspects of nonalcoholic fatty liver disease (NAFLD) and also prevent this disease is examined. METHODS:We conducted a systematic review according to the PRISMA guidelines. All searches for writing this review is based on the papers was found in PubMed (MEDLINE), Cochrane database and Scopus in August and September 2014 for topic of NAFLD in Asia and the way of prevention of this disease, with no language limitations. All relevant articles were accessed in full text and all relevant materials was evaluated and reviewed. RESULTS:NAFLD is the most common liver disorder in worldwide, with an estimated with 20%-30% prevalence in Western countries and 2%-4% worldwide. The prevalence of NAFLD in Asia, depending on location (urban vs rural), gender, ethnicity, and age is variable between 15%-20%. According to the many studies in the world, the relationship between NAFLD, obesity, diabetes mellitus, and metabolic syndrome (MS) is quiet obvious. Prevalence of NAFLD in Asian countries seems to be lower than the Western countries but, it has increased recently due to the rise of obesity, type 2 diabetes and MS in this region. One of the main reasons for the increase in obesity, diabetes and MS in Asia is a lifestyle change and industrialization. Today, NAFLD is recognized as a major chronic liver disease in Asia. Therefore, prevention of this disease in Asian countries is very important and the best strategy for prevention and control of NAFLD is lifestyle modifications. Lifestyle modification programs are typically designed to change bad eating habits and increase physical activity that is associated with clinically significant improvements in obesity, type 2 diabetes and MS. Non-alcohol fatty liver disease in Asia: Prevention and planning in Asian countries particularly in Arab countries because of high prevalence of obesity, diabetes and MS. CONCLUSION: Prevention of NAFLD is very important SYSTEMATIC REVIEWS

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Correlates of Type 2 diabetes mellitus in children, adolescents and young adults in north India: a multisite collaborative case‐control study

Abstract: Early identification of the simple clinical, anthropometric and biochemical parameters which are strongly associated with early onset T2DM in young Asian Indians may be useful for primary prevention.

Cited by 51 publications

References 26 publications

Secular Trends in Obesity, Regional Adiposity and Metabolic Parameters among Asian Indian Adolescents in North India: A Comparative Data Analysis of Two Selective Samples 5 Years Apart (2003, 2008)

Secular Trends in Obesity, Regional Adiposity and Metabolic Parameters among Asian Indian Adolescents in North India: A Comparative Data Analysis of Two Selective Samples 5 Years Apart (2003, 2008)

“Study of Total Cholesterol (Tc), Triacylglycerols (Tg), High Density Lipoprotein Cholesterol (Hdl-C) in Type Ii Diabetes Mellitus.”

Non-alcohol fatty liver disease in Asia: Prevention and planning

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