Objective: There are probably 100 million people in the world with diabetes mellitus (DM), and incidences of diabetes are on the rise. Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardiovascular disorders. The aim of this study is to investigate the total cholesterol (TC), triacylglycerols (TGs), high-density lipoprotein cholesterol (HDL-C) in Type 2 DM, and healthy controls.
Methods:The study was conducted on 50 controls and 50 Type 2 diabetic subjects between age group of 30 and 60 years. Serum TC was determined by an enzymatic (cholesterol oxidase/phenol-aminophenazone [PAP]) colorimetric method and TGs were determined by an enzymatic (glycerol phosphate oxidase-PAP) method, and HDL-C was estimated by a precipitant method. Statistical analysis was done using unpaired t-test.
Results:The mean value of TC, TGs, and HDL-C in normal subjects is 165.5±24.24, 118.7±41.58, 28.38±7.85 mg/dl, respectively, and the value of TC, TGs, and HDL-C in diabetic patients is 179±31.69, 164.35±27.93, 25.4±6.86 mg/dl, respectively. The observed difference in the means of TC, TGs, and HDL-C in normal and diabetic are statistically significant (p<0.05).
Conclusion:From the present study, it is concluded that TC, TGs, and HDL-C levels for all persons with Type 2 DM should be done as a routine test. Furthermore, early diagnosis and treatment of dyslipidemia can be used as a preventive measure for the development of cardiovascular disease in Type 2 diabetes.
143 Background: There is limited data comparing intensity modulated radiation therapy (IMRT) and 3D conformal radiation therapy (3DCRT) in node-negative patients with cancer of the distal esophagus. Methods: Eight patients with node-negative cancer of the distal esophagus measuring 1-5 cm tumors were selected for this study. Target volumes were generated for all patients based on standard current practice; 3DCRT and IMRT plans optimized to obtain minimum dose to the heart were then created using the using the Eclipse Treatment Planning. Conformality index (CI, the amount of target volume covered by the prescription dose) and conformation number (CN, the amount of normal tissue receiving prescription dose) were calculated. Dose volume histograms also were generated and clinically relevant parameters were extracted and compared for each planning modality using paired T-tests. Each patient served as his or her own control. Results: The difference in CI ranged from 0-0.01, indicating equivalent target coverage for each patient. IMRT produced superior CN (mean CN = 0.74) vs. the 3DCRT plans (mean CN = 0.45). Heart V40 and the maximum dose to spinal cord were lower for IMRT (mean difference in heart V40 = 34.5%, p=0.0006 and mean difference in the maximum dose to the spinal cord = 18.1 Gy, p=0.0005) but lung V5 and V20 were lower for 3DCRT (mean difference in lung V5 = -21.3%, p=0.0026 and mean difference in lung V20 = -5.2%, p=0.0014). Conclusions: When optimized to minimize dose to the heart, IMRT plans were substantially more conformal to the target structures with less dose to the heart as compared to 3DCRT plans; however this occurred at the expense of increased dose delivered to the lung. No significant financial relationships to disclose.
Introduction: Acute renal failure (ARF) is seen mostly in Plasmodium falciparum infection, but P. vivax and P. malariae can cause renal impairment rarely. Malarial ARF is commonly found in adults and older children with falciparum malaria. Material & Methods: Ninety five patients from Pad. Dr. D Y Patil Hospital and Research Centre, Navi Mumbai, were included in this study during July-Aug 2010. Out of 95 patients 38 patients are control, 10 patients infected by P. falciparum, 36 patients infected by P. vivax and 11 are mix infection of P. falciparum & P. vivax. All patients' diagnosis is confirmed by clinical examination as well as peripheral blood smear. Results: Renal involvement present as electrolyte abnormality as Hyponatraemia, Oliguria, Uraecemia and jaundice. Acute Renal Failure (ARF) occurs as a complication of P. falciparum malarial infection in less than 1% of cases, but the mortality reported up to 40%. Malarial ARF is diagnosed when serum creatinine level greater than 3 mg/dL and/or urinary output is less than 400 ml in 24 hours. The serum concentrations of Creatinine, urea, proteins ( Total proteins & albumin), Bilirubin (conjugated and total bilirubin) in malaria patients were significantly higher (p<0.05) than those of malaria free individuals. We conclude that renal dysfunction, acute renal failure and liver dysfunction are clinical features of malaria Conclusion: In spite of several researches and ultramodern techniques, mechanism of malarial ARF and its effective management has remained unclear. In many cases reversal of renal dysfunction takes place may be due to biotransformation of antigen and response of immune system. In addition, the literature is almost silent on the mechanism of recent increase in incidence of ARF and multiple complications specifically around coastal regions in India.
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