Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue

González

et al. 2012

Rev. chil. infectol.

Dengue is considered an emerging disease with an increasing prevalence especially in South America. In 2002, an epidemic of classic Dengue (DENV-1) occurred unexpectedly on Easter Island, where it had never been detected before. It reappeared in 2006-2007 and 2008, 2009 and 2011. The aim of this study was to estimate the most relevant parameters of the epidemiological dynamics of transmission of Dengue on Easter Island and to model the dynamics since 2002, comparing the predictions with the actual situation observed. Of the total cases, 52.27% were females and 47.73% men. The average age of infection was 31.38 ± 18.37 years, similar in men and women.

Section: Introductionunclassified

Dinámica epidemiológica del dengue en Isla de Pascua

González

et al. 2012

Rev. chil. infectol.

“…Results of one study have shown that serum GPx levels were associated with spontaneous bleeding events and with serum triglycerides levels in dengue patients. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue 48 . In this regard, a recent study reported that increased triglycerides levels were observed mainly in severe dengue patients 49 .…”

Section: Markers Methods Reported Valuesmentioning

confidence: 85%

A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis

Orozco

Redondo²,

Alvis-Guzmán

2015

Colomb Med

Objective Our objective was to systematically review the published observational research related to the role of oxidative-nitrosative stress in pathogenesis of dengue. Methods We searched electronic databases (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO, LILACS via Virtual Health Library, Google Scholar) using the term: dengue, dengue virus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants, free radicals, oxidized lipid products, lipid peroxides, nitric oxide, and nitric oxide synthase. Articles were selected for review by title and abstract excluding letter, review, in vivo and in vitro studies, and duplicates studies. Selected articles were reviewed for study design, original purposes, sample size, main outcomes, methods, and oxidative-nitrosative stress markers values. Results In total, 4331 non-duplicates articles were identified from electronic databases searches, of which 17 were eligible for full text searching. Data from the observational studies originate from Asian countries (52,9%; 9/17), South American countries (29.4%; 5/17), and Central America and the Caribbean countries (17.7%; 3/17). Case-control study was the type of design most common in researches reviewed. The 1997 World Health Organization (WHO) dengue case classification criteria were used in all studies included in this review. Conclusions Based on published data found in peer-reviewed literature, oxidative and nitrosative stress are demonstrated by changes in plasma levels of nitric oxide, antioxidants, lipid peroxidation and protein oxidation markers in patients with dengue infection. Additionally, elevated serum protein carbonyls and malondialdehyde levels appear to be associated with dengue disease severity.

“…Oxidative stress triggers multiple hematological responses, including aberrant platelet activation, coagulation induction, endothelial inflammation, and increased vascular permeability ( Delaney et al, 2016 ; Fuentes et al, 2018 ; Ghosh et al, 2015 ; Pleiner et al, 2003 ; Scalise et al, 2016 ; Ulker et al, 2016 ; Wang et al, 2016 ). Blockade of oxidative stress responses and ROS production have been implicated in both hemorrhagic fever virus pathogenesis ( Aydin et al, 2013 ; Karadag-Oncel et al, 2014 ; Narayanan et al, 2014 , 2011 ; Rojas et al, 2007 ; Soundravally et al, 2014 , 2008a , 2008b ) and response to lipopolysaccharide ( Gandhirajan et al, 2013 ; Sennoun et al, 2009 ). As these conditions share many features with severe EVD, it is possible that increased oxidative stress coupled with defective antioxidant responses can directly result in vascular injury and coagulopathy.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes

Price¹,

Okumura

Haddock

et al. 2020

Cell Reports