Corrective effects of acerola (Malpighia emarginata DC.) juice intake on biochemical and genotoxical parameters in mice fed on a high-fat diet

Leffa, Daniela Dimer; Silva, Juliana da; Daumann, Francine; Dajori, Ana Luiza F; Longaretti, Luiza Martins; Damiani, Adriani Paganini; Lira, Fábio Santos; Campos, Fernanda; Ferraz, Alexandre de Barros Falcão; Corrêa, Dione Silva; Andrade, Vanessa Moraes de

doi:10.1016/j.mrfmmm.2013.11.005

Cited by 40 publications

(18 citation statements)

References 36 publications

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“…On the other hand, Leffa et al 29 not only used a lower dose of vitamin C (1 mg/kg) than the dose used herein, but also treated their rats for a shorter period (13 weeks). In the present study, the difference in weight gained by groups VitCIS and IS only appeared in week twelve.…”

Section: Discussionmentioning

confidence: 88%

“…Both AUC showed that vitamin C reduced glucose intolerance. Leffa et al 29 found that the group given vitamin C supplements or vitamin C-containing juices did not have smaller glucose AUC than the group treated with the cafeteria diet. Corroborating the present study, Al-Shamsi et al 5 found that 10mg/kg of vitamin C reduced fasting glycemia and glucose AUC.…”

Section: Discussionmentioning

confidence: 99%

“…Moderate and high doses (50mg/kg; 100mg/kg) of vitamin C for 10 days slowed down weight gain more effectively, especially after DM onset 5 . Still in this context, Leffa et al 29 assessed the effect of vitamin C (1mg/kg) in rats given a cafeteria diet for 13 weeks and also found that animals co-treated with vitamin C gained less weight. Nonetheless, the mean energy intake of the group fed the cafeteria diet was lower than that of the control group, despite the cafeteria diet's high energy density and low nutrient density.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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“…Other studies have also indicated that acerola has antioxidant activity using a 1, 1-diphenyl-2-picrylhydrazyl radical scavenging assay [16, 46, 47]. Some studies have reported that the antioxidant activity of acerola juice depends on its polyphenols and AA contents [21, 48]. Because there was no difference in AA content between the AA (+) and AJ groups, as illustrated in Fig 1, various polyphenols from acerola juice may contribute to the reduction of UVB-induced skin pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice

Sato

Uchida

Aoki³

et al. 2017

PLoS ONE

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Background/AimsAcerola (Malpighia emarginata DC.) is a fruit that is known to contain high amounts of ascorbic acid (AA) and various phytochemicals. We have previously reported that AA deficiency leads to ultraviolet B (UVB)-induced skin pigmentation in senescence marker protein 30 (SMP30)/gluconolactonase (GNL) knockout (KO) hairless mice. The present study was undertaken to investigate the effects of acerola juice (AJ) intake on the skin of UVB-irradiated SMP30/GNL KO mice.Research design/Principal findingsFive-week old hairless mice were given drinking water containing physiologically sufficient AA (1.5 g/L) [AA (+)], no AA [AA (-)] or 1.67% acerola juice [AJ]. All mice were exposed to UVB irradiation for 6 weeks. UVB irradiation was performed three times per week. The dorsal skin color and stratum corneum water content were measured every weekly, and finally, the AA contents of the skin was determined. The skin AA and stratum corneum water content was similar between the AA (+) and AJ groups. The L* value of the AA (+) group was significantly decreased by UVB irradiation, whereas AJ intake suppressed the decrease in the L* value throughout the experiment. Moreover, in the AJ group, there was a significant decrease in the expression level of dopachrome tautomerase, an enzyme that is involved in melanin biosynthesis.ConclusionThese results indicate that AJ intake is effective in suppressing UVB-induced skin pigmentation by inhibiting melanogenesis-related genes.

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“…This decrease in glucose disposition by the energetic metabolism can be responsible, due to the increased fatty acid utilization, for maintaining the energetic demand, ameliorating the vicious cycle of lipolysis-inflammation, and mobilizing the free fatty acids from lipolysis to be used as an energy source. However, recently, Leffa et al [27] showed that acerola juice is not able to alter or reverse insulin resistance in mice fed a high-fat diet. More studies are needed to achieve a better understanding of the involved mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet

et al. 2014

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BackgroundObesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue.To elucidate the effects of natural dietary components on the inflammatory and metabolic consequences of obesity, we examined the effects of unripe, ripe and industrial acerola juice (Malpighia emarginata DC.) on the relevant inflammatory and lipolysis proteins in the adipose tissue of mice with cafeteria diet-induced obesity.Materials/methodsTwo groups of male Swiss mice were fed on a standard diet (STA) or a cafeteria diet (CAF) for 13 weeks. Afterwards, the CAF-fed animals were divided into five subgroups, each of which received a different supplement for one further month (water, unripe acerola juice, ripe acerola juice, industrial acerola juice, or vitamin C) by gavage. Enzyme-linked immunosorbent assays, Western blotting, a colorimetric method and histology were utilized to assess the observed data.ResultsThe CAF water (control obese) group showed a significant increase in their adiposity indices and triacylglycerol levels, in addition to a reduced IL-10/TNF-α ratio in the adipose tissue, compared with the control lean group. In contrast, acerola juice and Vitamin C intake ameliorated the weight gain, reducing the TAG levels and increasing the IL-10/TNF-α ratio in adipose tissue. In addition, acerola juice intake led to reductions both in the level of phosphorylated JNK and to increases in the phosphorylation of IκBα and HSLser660 in adipose tissue.ConclusionsTaken together, these results suggest that acerola juice reduces low-grade inflammation and ameliorates obesity-associated defects in the lipolytic processes.

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Corrective effects of acerola (Malpighia emarginata DC.) juice intake on biochemical and genotoxical parameters in mice fed on a high-fat diet

Cited by 40 publications

References 36 publications

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice

Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet

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