Correction to Sesquiterpene Lactones from <i>Anthemis melanolepis</i> and Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile

Saroglou, Vasiliki; Karioti, Anastasia; Rancic, Ana; Dimas, Kostas; Koukoulitsa, Catherine; Zervou, Maria; Skaltsa, Helen

doi:10.1021/np200975x

Cited by 4 publications

(5 citation statements)

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“…Nine sesquiterpene lactones, anthemin A, 1α-hydroxydeacetylirinol-4 α,5β-epoxide, anthemin C, tatridin A, 1-epi-tatridin B, anthemin B, 6-deacetyl-β-cyclopyrethrosin, elegalactone A and 1β,4 α,6trihydroxyeudesm-11-en-8 -12-olide were isolated from the aerial parts of Anthemis melanolepis. All sesquiterpene lactones showed an inhibitory effect against almost all fungi tested (Saroglou et al, 2010), which adds to evidence from previous studies concerning related compounds isolated from other Anthemis species (Konstantinopoulou et al, 2003).…”

Section: Sesquiterpene Lactonessupporting

confidence: 85%

Natural Products from Plants and Fungi as Fungicides

Sokóvić¹,

Glamočlija²,

Ćirić³

2013

Fungicides - Showcases of Integrated Plant Disease Management From Around the World

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Section: Sesquiterpene Lactonessupporting

confidence: 85%

Natural Products from Plants and Fungi as Fungicides

Sokóvić¹,

Glamočlija²,

Ćirić³

2013

Fungicides - Showcases of Integrated Plant Disease Management From Around the World

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“…2,3 The genus Anthemis is characterized mainly by the presence of sesquiterpene lactones, belonging to germacranolides, eudesmanolides, guaianolides and flavonoids. [4][5][6] Constituents of Anthemis species were proven to exert anti-inflammatory, hepatoprotective and antioxidant activities. 7,8 Anthemis species are commonly used in folk medicine in the treatment of gastrointestinal disorders, hemorrhoid, dysmenorrhoea and stomach ache in Turkish traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Review on Chemical Constituents and Biological Activities of Genus Anthemis

Boukhary¹,

Aboul-Ela²,

El-Lakany³

2019

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Genus Anthemis of Family Asteraceae contains mainly flavonoids, sesquiterpene lactones belonging to germacranolides, eudesmanolides, guaianolides, sterols and essential oils. The Plants of genus Anthemis have been known to have anti-inflammatory, hepatoprotective and antioxidant activities due to their rich contents of important physiological and biological compounds. They are referred to as nature's biological response modifier's and are involved in energy transfer, photosensitization and morphogenesis. Several clinical studies have shown that people who take diets rich in flavonoids and sesquiterpenes have reduced risk of developing cancer and cardiovascular diseases. This article covers most of constituents of plants of genus Anthemis reported from 2002 up to 2018. Furthermore, the biological activities of plants of genus Anthemis will be presented.

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“…(Asteraceae), some of which showed antimicrobial activity with both Gram positive and Gram negative bacteria and fungi and possessed cytotoxic potential in human cancer cell lines (Saroglou et al 2010). We report here the chemical constituents and cytotoxic activities of methanol and dichloromethane (DCM) extracts of entire A. mirheydari plants, which is an annual and endemic specie growing wild in the southern parts of Iran.…”

Section: Introductionmentioning

confidence: 99%

“…Thirty-nine annual and perennial species of the genus Anthemis are found in Iran, including 15 endemic (Mozaffarian 1996). The cytotoxic activity of different species of Anthemis is attributed to the presence of different types of natural products such as sesquiterpenes lactones (Collu et al 2008;Saroglou et al 2010;Bai et al 2011). The essential oils of Anthemis xylopoda O. Schwarz (Asteraceae) from Turkey consist of mostly monoterpenoids that exhibit potent antibacterial properties (Uzel et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

Jassbi

Firuzi

Miri

et al. 2016

Pharmaceutical Biology

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Context The genus Anthemis L. (Asteraceae) comprises about 195 species which are widely used in the pharmaceutical, cosmetic and food industries. Objective Anthemis mirheydari Iranshar, an endemic plant from Iran, was investigated for its cytotoxic properties and chemical constituents. Materials and methods The whole parts of the plant (320 g) were extracted by dichloromethane and methanol for four days, successively. The cytotoxic activity of both dichloromethane and methanol extracts were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric methods against three human cancer cell lines including LS180, MCF-7 and MOLT-4. Different concentrations (10-100 mg/mL) of the plant extracts were tested to obtain IC 50 values. The dichloromethane extract of A. mirheydari was subjected to silica gel-column and thin layer chromatography for purification of its chemical constituents and the isolated compounds were further tested against MOLT-4 cells. The structures of the pure compounds were elucidated using different spectral data including nuclear magnetic resonance and electron impact mass spectra. Results The IC 50 values of the dichloromethane extract were 30.8 ± 6.7, 25.2 ± 6.5 and 8.6 ± 1.1 mg/mL (means ± standard error) for the above-mentioned cell lines, respectively. Two triterpenoids, taraxasterol (1) and pseudotaraxasterol (2), one sterol, b-sitosterol (3) and one coumarin, 7-methoxycoumarin (4) were isolated from the extract. The IC 50 of the mixture of compounds 1 and 2 as well as compounds 3 and 4 were higher (4100 mM) than that reported for the dichloromethane extract against MOLT-4 cells. Conclusion The dichloromethane extract was the most active one among the tested material.ARTICLE HISTORY

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Correction to Sesquiterpene Lactones from Anthemis melanolepis and Their Antibacterial and Cytotoxic Activities. Prediction of Their Pharmacokinetic Profile

Abstract: The formula that has been used for the calculation of the LC 50 values is 100 × (T − T 0 /T 0 ) = −50.The authors regret any inconvenience caused by the omission of this information at the time of publication.

Cited by 4 publications

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Natural Products from Plants and Fungi as Fungicides

Natural Products from Plants and Fungi as Fungicides

Review on Chemical Constituents and Biological Activities of Genus Anthemis

Cytotoxic activity and chemical constituents ofAnthemis mirheydari

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