Review on Chemical Constituents and Biological Activities of Genus Anthemis

Boukhary, Rima; Aboul-Ela, Maha; El-Lakany, Abdalla

doi:10.5530/pj.2019.11.180

Cited by 7 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to the present study, caffeic acid, rutin, naringenin, chlorogenic acid, patuletin, and quercetin have been previously found in A. tinctoria inflorescences. However, apigenin-7-glucoside and rosmarinic acid were not detected in the current study although they were detected by previous authors [ 8 , 9 ].…”

Section: Discussioncontrasting

confidence: 85%

“…The main compounds found in the essential oil are α -eudesmol, γ -cadinol, γ -cadinene, decanoic acid, T-muurolol, 1,8-cineole, and β -pinene [ 6 , 7 ]. Chlorogenic acid, gentisic acid, and rosmarinic acid, as well as the flavonoids apigenin-7-glucoside, patuletin, and quercetin, have been found in the aerial parts of A. tinctoria [ 8 , 9 ]. A new flavonoid, tinctosid, has been identified [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Phytochemical Profile and Anticancer Activity of Anthemis tinctoria and Angelica sylvestris Used in Estonian Ethnomedicine

Raal

Jaama

Utt

et al. 2022

Plants

View full text Add to dashboard Cite

The aerial parts of Anthemis tinctoria L. and Angelica sylvestris L. and the roots of A. sylvestris have been used as traditional anticancer remedies in Estonian ethnomedicine. The aim of this study was to investigate content of essential oils (by gas chromatography) and polyphenolic compounds (using two different methods of high performance liquid chromatography–mass spectrometry (HPLC–MS)) of both plant species, as well as the in vitro anti-cancer effects of their essential oils and methanolic extracts. The average (n = 5 samples) yield of essential oils was 0.15%, 0.13%, and 0.17%, respectively. The principal compounds of the essential oil from the aerial parts of A. tinctoria were palmitic acid (15.3%), p-cymene (12.6%), and α-muurolene (12.5%), and α-pinene (45.4%), p-cymene (15.5%), and β-myrcene (13.3%) in aerial parts of A. sylvestris, while isocaryophyllene oxide (31.9%), α-bisabolol (17.5%), and α-pinene (12.4%) were the main constituents in the roots. The most abundant phenolic compounds in aerial parts were the derivatives of caffeic acid, quinic acid, and quercetin; the main compounds in roots of A. sylvestris were chlorogenic acid, quinic acid, and naringenin. The strongest anticancer effects were observed in essential oils of A. sylvestris roots and aerial parts on human carcinoma in the mouth cells (KB, IC50 19.73 μg/mL and 19.84 μg/mL, respectively). The essential oil of A. tinctoria showed a strong effect on KB and LNCaP cells (27.75–29.96 μg/mL). The methanolic extracts of both plants had no effect on the cancer cells studied.

show abstract

Section: Discussioncontrasting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

The Phytochemical Profile and Anticancer Activity of Anthemis tinctoria and Angelica sylvestris Used in Estonian Ethnomedicine

Raal

Jaama

Utt

et al. 2022

Plants

View full text Add to dashboard Cite

show abstract

“…Fiber supplementation has shown an effective beneficial effect in the treatment of symptomatic hemorrhoids. In studies with multiple intervals of follow-up, results indicated positive outcomes associated with fiber supplementation concerning issues like prolapse, pain, and itching [8].…”

Section: Fiber Supplementmentioning

confidence: 98%

Oral Catechins and Epicatechins as a Treatment Modality for Hemorrhoids

Dewan,

Shinde,

Kondekar

2024

Anorectal Disorders - From Diagnosis to Treatment

View full text Add to dashboard Cite

Hemorrhoids, a prevalent medical condition impacting millions globally, frequently necessitate effective yet minimally invasive treatment methods. This review delves into the prospects of utilizing oral catechins and epicatechins, naturally occurring polyphenolic compounds present in diverse dietary sources, as an innovative avenue for addressing hemorrhoids. These compounds have antioxidant and anti-inflammatory attributes, which may help alleviate hemorrhoid symptoms. An understanding of the anatomy and pathophysiology of hemorrhoids, emphasizing the need for accessible and versatile treatment options. Subsequently, the focus turns to a detailed exploration of catechin and epicatechin, encompassing their chemical composition, natural origins, and mechanism of action. The core of this review presents a comprehensive analysis of the existing literature, including randomized controlled trials that examine the efficacy of oral catechin and epicatechin supplementation in alleviating hemorrhoidal symptoms. To conclude, this article highlights the potential of oral catechin and epicatechin supplementation as a non-invasive and natural approach to managing hemorrhoids. While promising findings have emerged, further research is essential to solidify their role in hemorrhoid treatment. The comprehensive assessment of existing literature and critical evaluation of these compounds’ mechanism of action provides valuable insights into their viability as a treatment modality for this common and often distressing medical concern.

show abstract

“…Generally, plants that belong to the genus Anthemis are rich in flavonoids, terpenes, and volatile oils. Thus, these plants usually exhibit anti-inflammatory, hepatoprotective, antioxidant, and anti-cancer properties [5].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of luteolin, a flavonoid compound isolated from <i>Anthemis palestina</i>

Tabaza,

Seong,

Kim

et al. 2024

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To determine the active principle responsible for the cytotoxic effect of Anthemis palestina (Reut. ex Kotschy) Reut. ex Boiss. (Asteraceae). Methods: A bioassay-guided fractionation was used to isolate the active principle, luteolin, which structure was elucidated using 1H and 13C NMR. The cytotoxic effects of luteolin and doxorubicin (positive control) in the breast cancer cell lines MDA-MB-231 and MCF-7, and in normal fibroblasts, were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Results: Luteolin was isolated from the ethyl acetate extract of the aerial parts of Anthemis palestina. With an IC50 value of 14.91 ± 5.77 µM for MDA-MB-231 cells, luteolin was less active than doxorubicin. However, with respect to MCF-7 cells, there was no significant difference in the cytotoxicity values of luteolin and doxorubicin, with IC50 value of 29.28 ± 11.85 µM for luteolin. However, with an IC50 value of 51.39 ± 18.51 µM against fibroblasts, luteolin was significantly safer than doxorubicin. Conclusion: Luteolin might be responsible for the cytotoxicity of Anthemis palestina. The high level of luteolin cytotoxicity indicates the potential benefits of Anthemis palestina, not only in terms of its taste, but also for its likely positive therapeutic impact on cancer, especially breast cancer.

show abstract

Review on Chemical Constituents and Biological Activities of Genus Anthemis

Cited by 7 publications

References 26 publications

The Phytochemical Profile and Anticancer Activity of Anthemis tinctoria and Angelica sylvestris Used in Estonian Ethnomedicine

The Phytochemical Profile and Anticancer Activity of Anthemis tinctoria and Angelica sylvestris Used in Estonian Ethnomedicine

Oral Catechins and Epicatechins as a Treatment Modality for Hemorrhoids

Cytotoxicity of luteolin, a flavonoid compound isolated from <i>Anthemis palestina</i>

Contact Info

Product

Resources

About