Correction to “(Pyridin-2-yl)-NHC Organoruthenium Complexes: Antiproliferative Properties and Reactivity Toward Biomolecules”

Movassaghi, Sanam; Singh, Sukhjit; Mansur, Aewan; Tong, Kelvin K. H.; Hanif, Muhammad; Holtkamp, Hannah U.; Söhnel, Tilo; Jamieson, Stephen M.F.; Hartinger, Christian G.

doi:10.1021/acs.organomet.8b00706

Cited by 3 publications

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“…Peruzzini et al reported water-soluble ruthenium-PPh 3 complexes that interact with DNA strongly, which is similar to the behavior demonstrated by a platinum-PPh 3 derivative. Hartinger and Liu reported a promising cytotoxic behavior of heterocyclic carbene-based ruthenium imine complexes. The Marchetti and Lui groups developed half-sandwich ruthenium(II) imine complexes and observed that the cytotoxicity and selectivity strongly depend on the nature of the ligands on N substituents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

et al. 2021

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The synthesis and characterization of chiral pincer-ruthenium complexes of the type (R2NNN)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3-dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.

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