Synthesis, characterization, catalytic and biological application of half-sandwich ruthenium complexes bearing hemilabile (κ2-C,S)-thioether-functionalised NHC ligands

Abstract

A series of cationic Ru(ii)(η6-p-cymene) complexes with thioether-functionalised N-heterocyclic carbene ligands have been prepared and fully characterized.

Synthesis, Structural Characterization and Antiproliferative Activity of Gold(I) and Gold(III) Complexes Bearing Thioether‐Functionalized N‐Heterocyclic Carbenes

“…The same behaviour is also observed by increasing the temperature up to 323 K. Either increasing or decreasing the temperature, the initial spectrum could be restored, when back to room temperature. This fluxional behaviour suggests that in chloroform a weak coordination of the thioether moiety to the gold centre can occur [24,38] …”

“…The imidazolium salts used in this study are depicted in Figure 2 and their synthesis and characterization were recently reported by some of us [24,25] …”

“…Elemental analysis were carried out with a Thermo Scientific FLASH 2000 apparatus. The imidazolium salts were prepared following published procedures [24,25] …”

“…Thus, co‐administration of a “chemoprotective agent”, such as S‐containing oligopeptides, can significantly reduce the outbreak of side effects [23] . Recently, studies on chemoprotective action and cytotoxic properties of sulfur‐containing NHC ruthenium(II) and platinum(II) complexes have been reported by some of us [24,25] . We decided to expand the scope of the metal complexes with such type of ligands and in this paper, we report on the synthesis, characterization and the preliminary antiproliferative results of gold(I) and gold(III) complexes bearing thioether‐functionalized NHCs.…”

Metal‐Metal Interactions in Bi‐, Tri‐ and Multinuclear Fe, Ru and Os N‐Heterocyclic Carbene Complexes and their Catalytic Applications

“…Owing to the prevalence of Fe, Ru and Os NHC complexes in the development of new photosensitizers, [28] synthetic protocols in organic chemistry, hence compounds of interest for various catalytic reactions and interesting candidates for biological applications [29] continues to be an active area of research. In comparison to the interesting progress of Ru NHC complexes as olefin metathesis catalysts, the Fe NHC complexes have been less explored, but their investigation has freshly emerged as a fast growing field of research, especially in catalysis.…”