Correction of homeostatic mechanisms of humoral regulation of bone remodeling processes in piglets with pathology of vitamin-mineral metabolism

Abstract

The aim of the research was to study the correction of ossification processes and the mechanisms of humoral regulation of this process in the pathology of vitamin-mineral metabolism against the background of an immunosuppressive state in piglets. As a result of the experiment, it was found that proposed pharmacological correction scheme contributes to an increase in the level of total calcium (3.48 ± 0.29 mmol/l), ionized calcium (1.65 ± 0.07 mmol/l), ion-exchange calcium (2.52 ± 0.05 mmol/l), and protein-bound calcium (0.54 ± 0.06 mmol/l), 2, 3-diphosphoglycerate (1.43 ± 0.02 mmol/l), vitamin A (2.63 ± 0.09 μg/l), citric acid (2.90 ± 0.16 μg/l), a significant decrease in alkaline phosphatase activity (2.02 ± 0.04 mmol/l). Optimization of the structural and functional organization of the thyroid and parathyroid glands was noted, activation of hematopoiesis and bone tissue remodeling was observed in bone tissue, which suggests a pronounced reparative and osteoprotective effect of the proposed pharmacocorrection scheme.