In a previous study, exercise was shown to increase riboflavin requirements of active, normal weight young women. The present study examined the effect of exercise and weight loss on riboflavin status of moderately overweight women. The experiment was designed as a two-period cross-over with an initial base-line period and two 5-wk metabolic periods. The basic diet contained 1200 kcal with a riboflavin concentration of 0.8 mg/1000 kcal. Exercise consisted of a program of dance exercise. Riboflavin depletion, as measured by increased erythrocyte glutathione reductase activity coefficients and decreased urinary excretion of riboflavin, occurred during both nonexercise and exercise periods. Erythrocyte glutathione reductase activity coefficients increased from a base-line mean of 1.28 +/- 0.11 to 1.40 +/- 0.12 during nonexercise and to 1.49 +/- 0.16 during exercise. Urinary excretion of riboflavin fell from 48 +/- 12% of intake during base-line to 30 +/- 13% during nonexercise and to 19 +/- 6% during exercise. Riboflavin depletion was not related to the rate or composition of weight loss or to change in aerobic capacity.
The leptospirosis vaccine is the main method of preventing the occurrence and spread of leptospirosis. Compliance with the standards of manufacturing, labeling, and storage is mandatory for immunological preparations. All stages of vaccine production must comply with the rules established by the Ministry of Industry and Trade and ensure its safety for humans. The article presents epidemiological data on leptospirosis in the Russian Federation in the period from 2013 to 2018. A method for producing a vaccine against human leptospirosis is described. The leptospirosis vaccine is polyvalent using membrane technologies and semi-synthetic culture media. It eliminates the use of foreign protein and does not require cleaning. The vaccine is an opalescent liquid with sediment and a pH of 7.2-7.6 and it is not allowed to contain live leptospira. Four strains are used and a new strain has been developed and implemented. Vaccination is carried out according to epidemiological indicators. Leptospirosis suspension forms specific immunity for 1 year. During the production of the updated vaccine, it was necessary to study the virulent properties of the strains. Moreover, analyze the formation of specific antibodies to leptospira in the new vaccine and in the vaccine currently used. From 2018 to 2020, 5 series of experimental vaccines in the form of a 0.5 ml suspension were produced.
The development of effective methods of prevention and treatment of hypovitaminosis in piglets is one of the promising areas of veterinary science and practice. The article presents the results of studies obtained when evaluating the effectiveness of the use of complex multivitamin preparations from various manufacturers: Trivit (CJSC Mosagrogen, Russia), Tetrahydrovit (LLC NITA-PHARM, Russia), Dufalite (Zoetis Inc, USA). The peculiarity of vitamin nutrition of pigs is associated with the absence or insufficient synthesis of water-soluble B vitamins in their body, so they should always be present in the diet feed. In addition, pigs are in urgent need of the delivery of carotene, vitamin A, C, E, D with food, which is due to the intensity of metabolism and energy in the body; at the same time, the consumption of vitamin A and carotene increases exponentially. Based on the conducted studies, it was found that the most effective method of prevention and treatment of hypovitaminosis in suckling piglets is the use of the multivitamin drug Tetrahydrovit intramuscularly on the 1st day of life and again after 7 days at a dose of 1 ml per head 1 time per day.
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