The Coronavirus Disease 2019 (COVID‐19) pandemic is a global public health threat ravaging the health systems. In low and middle‐income countries (LMICs), COVID‐19 and several other challenges concurrently worsen the health outcome indicators. Interestingly, vaccines have been identified as the most reliable and cost‐effective public health intervention, and the governments in LMICs have instituted an array of plans to ensure every eligible person gets vaccinated. However, there is still considerable apathy around the use of the available COVID‐19 vaccines in LMICs which is impeding the fight against the COVID‐19 pandemic. In this paper, we explore the multiple interrelated factors behind low COVID‐19 vaccination coverage in LMICs. It is therefore recommended that the governments in LMICs embrace multicomponent and wide‐ranging strategies. This should involve utilising community‐based approaches such as community pharmacy‐led vaccination to promote community access to COVID‐19 vaccines and to revive trust in national health authorities by offering population‐specific, target‐driven, transparent, and timely communication to the community who they serve about the safety and efficacy of the COVID‐19 vaccine. Communication strategies should be tailored to reflect diverse political orientations as this can enhance vaccine acceptance. Additionally, local political parties and representative should be engaged in broad alliances to facilitate community mobilisation and support for vaccination campaigns. Also, relevant Nongovernmental Organisations and Community‐based Organisations should institute programs at the grassroots that incorporate the gatekeepers to the community aimed at influencing population behaviour regarding COVID‐19 vaccine hesitancy. Besides, the public health department in the ministry of health in LMICs should create more awareness, through social and mass media, particularly in the rural, semi‐urban, and slum communities about the pivotal role of vaccination. Thus, we opined that these strategies will help LMICs achieve the COVID‐19 vaccination target and further reposition the healthcare systems, and promote other public health interventions now and in the future.