Corpus Callosum in Patients with Obsessive-Compulsive Disorder: Diffusion-Tensor Imaging Study

Saito, Yukiko; Nobuhara, Kenji; Okugawa, Gaku; Takase, Katsunori; Sugimoto, Tatsuya; Horiuchi, Mami; Ueno, Chiho; Maehara, Minoru; Omura, Naoto; Kurokawa, Hiroaki; Ikeda, Koshi; Tanigawa, Noboru; Sawada, Satoshi; Kinoshita, Toshihiko

doi:10.1148/radiol.2462061469

Cited by 73 publications

(60 citation statements)

References 24 publications

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“…17,20 However, to our knowledge, no studies to date have investigated the axonal versus myelin contributions to the identified abnormalities in white matter integrity. By examining axial and radial diffusivity in patients with OCD, we have demonstrated that impaired white matter integrity in the body of the CC in this patient group is driven by a myelin abnormality.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] To date, 8 studies have examined white matter pathology in patients with OCD using DTI. 5,[16][17][18][19][20][21][22] However, the findings of these studies have been variable (Table 1), and no study has examined whether axonal injury or abnormal myelination explains the observed findings. In this study, our aim was to extend previous work and to examine alterations in fractional anisotropy as well as measures of axial and radial diffusivity in a sample of patients with OCD and healthy controls using a well-validated Tract-Based Spatial Statistics (TBSS) technique.…”

Section: Introductionmentioning

confidence: 99%

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White matter microstructure in patients with obsessive–compulsive disorder

Bora

2011

J Psychiatry Neurosci

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Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

White matter microstructure in patients with obsessive–compulsive disorder

Bora

2011

J Psychiatry Neurosci

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“…All patients had received a diagnosis of OCD based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) [25]. We excluded patients who: had substantial medical illness or neurological (e.g., Tourette syndrome, Huntington disease, and Parkinson disease), pulmonary, cardiac, renal, hepatic, endocrine, or metabolic disorders; had DSM-IV-defined dementia, delirium, schizophrenia, schizoaffective disorder, delusional disorder, brief reactive psychosis, or psychotic disorders not otherwise specified; had DSM-IV-defined mental retardation; had lacunar infarcts; were currently or previously dependent on or abusers of DSM-IVdefined alcoholic or psychoactive substances; and/or were pregnant [26]. For the estimation of obsessive and compulsive symptoms, the Japanese version of the Yale Brown Obsessive Compulsive Scale was applied; its average score was 25.0 ± 8.5.…”

Section: Subjectsmentioning

confidence: 99%

Hyperactivation of the Frontal Control Network Revealed by Symptom Provocation in Obsessive-Compulsive Disorder Using EEG Microstate and sLORETA Analyses

Yoshimura¹,

Pascual-Marqui²,

Nishida³

et al. 2018

Neuropsychobiology

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The aim of this study was to investigate the changes of brain electric field induced by symptom provocation in patients with obsessive-compulsive disorder (OCD) in comparison to healthy controls in the resting state. For this purpose, EEG recordings in conditions of initial rest, clean control, symptom provocation by imaginal exposure, and final rest were used for computing spatiotemporal activity characteristics based on microstate segmentation. Within-group comparisons were significant for the symptom provocation condition: OCD showed high global field power (GFP) and transition rates into a medial frontal microstate, whereas healthy controls showed high frequency of occurrence and high percent of dwelling time for a medial occipitoparietal microstate. Between-group comparisons demonstrated significantly lower GFP and dwelling time for the medial occipitoparietal microstate in OCD in several conditions including initial rest and symptom provocation. In addition, OCD compared to healthy controls showed significant instability of the medial occipitoparietal microstate, with high preference for transitions into the medial frontal microstate. In conclusion, during rest and symptom provocation, OCD patients make preferential use of a medial frontal brain network, with concomitant reduction of use of a medial occipitoparietal network, as shown by dwelling times, explained variance, and dynamic transition rates. These findings support the idea of a possible biological marker for OCD, which might correspond to pathological hyperactivation of the frontal control network.

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“…Others report that the quality of the WM (the ability to efficiently deliver neuronal signals) may be affected. Several studies (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) report either increased or decreased fractional anisotropy (FA) in OCD. FA is used to evaluate integrity of WM fibre tracts.…”

Section: Introductionmentioning

confidence: 99%