Increased fractional anisotropy in cerebellum in obsessive–compulsive disorder

Hartmann, T.; Vandborg, Sanne Kjær; Rosenberg, Raben; Sørensen, Leif; Videbech, Poul

doi:10.1017/neu.2015.57

Cited by 16 publications

(12 citation statements)

References 49 publications

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“…Few studies have investigated the white matter microstructure in the DMS and/or the SCP of OCD patients, and no consensus has been reached regarding these differences 69–71 . Of note, one recent study found an increase in FA in the cerebellum of OCD patients 72 , which is in line with our finding of increased FA in the SCP. In addition, although white matter microstructure is known to be altered in DM1 and DM2 38,39 , no studies have shown differences in specifically the CC, DMS, or SCP in patients with DM2.…”

Section: Discussionsupporting

confidence: 93%

Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

et al. 2019

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Obsessive–compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we identified insulin signaling being associated with OCD and here, we aim to further investigate this link in vivo. We studied TALLYHO/JngJ (TH) mice, a model of type 2 diabetes mellitus, to (1) assess compulsive and anxious behaviors, (2) determine neuro-metabolite levels by 1 H magnetic resonance spectroscopy (MRS) and brain structural connectivity by diffusion tensor imaging (DTI), and (3) investigate plasma and brain protein levels for molecules previously associated with OCD (insulin, Igf1, Kcnq1, and Bdnf) in these subjects. TH mice showed increased compulsivity-like behavior (reduced spontaneous alternation in the Y-maze) and more anxiety (less time spent in the open arms of the elevated plus maze). In parallel, their brains differed in the white matter microstructure measures fractional anisotropy (FA) and mean diffusivity (MD) in the midline corpus callosum (increased FA and decreased MD), in myelinated fibers of the dorsomedial striatum (decreased FA and MD), and superior cerebellar peduncles (decreased FA and MD). MRS revealed increased glucose levels in the dorsomedial striatum and increased glutathione levels in the anterior cingulate cortex in the TH mice relative to their controls. Igf1 expression was reduced in the cerebellum of TH mice but increased in the plasma. In conclusion, our data indicates a role of (abnormal) insulin signaling in compulsivity-like behavior.

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Section: Discussionsupporting

confidence: 93%

Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

et al. 2019

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“…Compared to HCs, the OCD group showed lower FA and higher RD values in the anterior cingulum, forceps minor, and ATR, which is in line with the classical cortico‐striato‐thalamo‐cortical (CSTC) circuit model of OCD 10,51‐53 and with prior research in this area. Specifically, reduced FA was previously reported in OCD patients within the anterior cingulum bundle, 7,9‐11,13,51,54 the forceps minor, 8,10,11,14,16‐18,20 and the ATR 21,55 . However, we also observed alterations outside the CSTC, including within the IFOF, which connects the frontal lobe to parieto‐occipito‐temporal regions.…”

Section: Discussionsupporting

confidence: 70%

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

Dikmeer

Beşiroğlu

Biase

et al. 2020

Acta Psychiatr Scand

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ObjectiveWe aimed to examine white matter microstructure and connectivity in individuals with obsessive–compulsive disorder (OCD) and their unaffected siblings, relative to healthy controls.MethodsDiffusion‐weighted magnetic resonance imaging (dMRI) scans were acquired in 30 patients with OCD, 21 unaffected siblings, and 31 controls. We examined white matter microstructure using measures of fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). Structural networks were examined using network‐based statistic (NBS).ResultsCompared to controls, OCD patients showed significantly reduced FA and increased RD in clusters traversing the left forceps minor, inferior fronto‐occipital fasciculus, anterior thalamic radiation, and cingulum. Furthermore, the OCD group displayed significantly weaker connectivity (quantified by the streamline count) compared to controls in the right hemisphere, most notably in edges connecting subcortical structures to temporo‐occipital cortical regions. The sibling group showed intermediate streamline counts, FA and RD values between OCD and healthy control groups in connections found to be abnormal in patients with OCD. However, these reductions did not significantly differ compared to controls.ConclusionTherefore, siblings of OCD patients display intermediate levels in dMRI measures of microstructure and connectivity, suggesting white matter abnormalities might be related to the familial predisposition for OCD.

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“…However, our findings can be regarded as being particularly robust, as they survived whole brain voxel-wise multiple comparison correction. Another robust aspect of the current study is that in addition to age and gender, we statistically controlled for two main common comorbidities (i.e., depression and anxiety) apart from demographic information, as these comorbidities are extremely common in OCD patients and can influence brain structure (Fontenelle and Hasler, 2008;Hartmann et al, 2016;Reess et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…However, DTI studies in OCD using either Voxel Based or Tract-Based Spatial Statistics (TBSS) have revealed rather heterogeneous results. For instance, FA values in OCD have been reported to be increased (Cannistraro et al, 2007;Gong et al, 2011;Nakamae et al, 2008;Yoo et al, 2007;Zarei et al, 2011) or decreased (Bora et al, 2011;Chiu et al, 2011;Fan et al, 2016;Gan et al, 2017;Garibotto et al, 2010;Nakamae et al, 2011;Oh et al, 2012;Zhou et al, 2018) or either increased or decreased in different brain regions (Hartmann et al, 2016;Lochner et al, 2012;Menzies et al, 2008b) such as corpus callosum (CC), cingulum bundle, and anterior and posterior limb of the internal capsule (ALIC and PLIC). These inconsistent results could be due to limited power to detect small effect sizes, heterogeneous symptom dimensions across recruited samples or DTI specific challenges.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging

Maleki

Chye

Zhang

et al. 2020

Psychiatry Research: Neuroimaging

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Recent neuroimaging studies in OCD have reported structural alterations in the brain, not limited to frontostriatal regions. While Diffusion Tensor Imaging (DTI) is typically used to interrogate WM microstructure in OCD, additional imaging metric, such as Magnetization Transfer Imaging (MTI), allows for further identification of subtle but important structural changes across both GM and WM. In this study, both MTI and DTI were utilised to investigate the structural integrity of the brain, in OCD in relation to healthy controls. 38 adult OCD patients were recruited, along with 41 age-and gender-matched controls. Structural T1, MTI and DTI data were collected. Case-control

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Increased fractional anisotropy in cerebellum in obsessive–compulsive disorder

Abstract: Decrease in fractional anisotrophy in forceps minor and increase in cerebellum were found, and they were not due to neither white matter hyperintensities nor morphology of the white matter. Cerebellar hyperconnectivity could be an important part of OCD pathophysiology.

Cited by 16 publications

References 49 publications

Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

White matter microstructure and connectivity in patients with obsessive‐compulsive disorder and their unaffected siblings

Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging

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