2011
DOI: 10.1503/jpn.100082
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Abstract: Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD g… Show more

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Cited by 63 publications
(68 citation statements)
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References 40 publications
(48 reference statements)
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“…AD, axial diffusivity; RD, radial diffusivity; MD, mean diffusivity; OCD, obsessive-compulsive disorder; HC, healthy controls. (Bora et al, 2011;Fan et al, 2012). Although Song et al (2003) suggested a higher RD to be associated with demyelination, others have shown that the interpretation of changes in RD and AD needs careful consideration, due to the inherent disbalance between fiber thickness and imaging resolution (WheelerKingshott and Cercignani, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…AD, axial diffusivity; RD, radial diffusivity; MD, mean diffusivity; OCD, obsessive-compulsive disorder; HC, healthy controls. (Bora et al, 2011;Fan et al, 2012). Although Song et al (2003) suggested a higher RD to be associated with demyelination, others have shown that the interpretation of changes in RD and AD needs careful consideration, due to the inherent disbalance between fiber thickness and imaging resolution (WheelerKingshott and Cercignani, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, a recent study demonstrated that radial diffusivity is increased and axial diffusivity unchanged in the corpus callosum of patients with OCD compared with controls. 29 These findings suggest a possible demyelination process in the commissural fibres in patients with OCD.…”
mentioning
confidence: 80%
“…Another whole brain investigation was performed in an Australian population and investigated fractional anisotropy as well as axial and radial diffusivity in patients with OCD. 29 The third study that used TBSS employed a whole brain analysis as well as an ROI-based approach to investigate fractional anisotropy, and axial and radial diffusivity in patients with OCD. 35 Our findings and the findings across these studies show overlap and are consistent with a corticostriatal model of OCD.…”
mentioning
confidence: 99%
“…Others report that the quality of the WM (the ability to efficiently deliver neuronal signals) may be affected. Several studies (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) report either increased or decreased fractional anisotropy (FA) in OCD. FA is used to evaluate integrity of WM fibre tracts.…”
Section: Introductionmentioning
confidence: 99%