Coronary slow flow phenomenon: Clinical findings and predictors

Sanati, Hamid Reza; Kiani, Reza; Shakerian, Farshad; Firouzi, Ata; Zahedmehr, Ali; Peighambari, Mohammadmehdi; Shokrian, Leila; Ashrafi, Peiman

doi:10.5812/cardiovascmed.30296

Cited by 38 publications

(58 citation statements)

References 22 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In two studies, low HDL-c level seems to be an independent predictor for CSF phenomenon. 10,24 In our study we found high TG levels in CSF group like previous studies. However we did not found a significant difference with HDL-c in two groups.…”

Section: Discussionsupporting

confidence: 88%

“…In previous studies demonstrated that low high-density lipoprotein cholesterol (HDL-c) and high triglyceride (TG) levels were associated with CSF. [9][10][11] Besides low-density lipoprotein cholesterol (LDL-c) was found associated with CSF. 12 As an "atherogenic index of plasma" LDL-c to HDL-c ratio (LDL-c/HDL-c) and TG to HDL-c (TG/HDL-c) are also associated with increased cardiometabolic risk, acceleration on the atherosclerotic plaque progression and worse cardiovascular events.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Kalaycı¹,

Suleyman²,

Köktürk³

2019

Turkiye Klinikleri J Cardiovasc Sci

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The association between serum lipid parameters and coronary slow-flow (CSF) phenomenon has been searched previously. The aim of our study was to determine the association between proportional serum lipid parameters and CSF. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We enrolled 93 stable patients randomly who had undergone coronary angiography and had near-normal coronary arteries with normal and slow coronary flow. Demographic, clinical and laboratory data were recorded retrospectively. Coronary flow velocity was evaluated by TIMI frame count (TFC). CFS phenomenon was defined as a TFC greater than 27 frames. Corrected TFC was calculated for the left anterior descending coronary artery. R Re es su ul lt ts s: : Fifty four patients were in CSF group and 39 patients were in control group. The mean age of the patients in CSF group was significantly higher than control group (55.4±9.5 vs. 50.5±9.8 years, p= 0.019). Triglyceride (TG) levels was found higher in CSF group than control group (187.3±103.4 mg/dl, 125.3±63.8 mg/dl, p<0.001). Total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL-c), TG/HDL-c, low density lipoprotein cholesterol to HDL-c ratio (LDL-c/HDL-c) and non-HDL-c levels were significantly higher in CSF group (p=0.007, p=0.004, p=0.044, p=0.018, respectively). TG and TG/HDL-c were found correlated with TFC (r=0.280, r=0.262, respectively). In multivariate logistic regression analysis age, smoking and TG were found statistically significant to predict of CSF. TG was found most associated with the presence of CSF (OR: 7.516, p=0.001). C Co on nc cl lu us si io on n: : Higher TG, TC/HDL-c, TG/HDL-c, LDLc/HDL-c and non-HDL-c levels were related with CSF phenomenon. K Ke ey yw wo or rd ds s: : Dyslipidemia; HDL-triglyceride; triglycerides; coronary slow flow; lipid ratio Ö ÖZ ZE ET T A Am ma aç ç: : Serum lipid parametreleri ve koroner yavaş akım (KYA) fenomeni arasındaki ilişki daha önce araştırılmıştır. Bizim çalışmamızın amacı oransal lipid parametreleri ile KYA arasındaki ilişkiyi araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Biz çalışmaya koroner anjiyografi yapılan ve normale yakın koroner arterleri olan, normal ve yavaş koroner akıma sahip 93 stabil hastayı randomize dahil ettik. Demografik, klinik ve laboratuvar verileri retrospektif olarak yerel veri tabanından bulunarak kaydedildi. Koroner akım velositesi miyokard infarktüsünde tromboliz kare sayısı (TFC) ile değerlendirildi. KYA fenomeni TFC'nin 27 kare üzerinde olması olarak tanımlandı. Sol ön inen koroner arter için düzeltilmiş TFC hesaplandı. B Bu ul lg gu ul la ar r: : KYA grubunda 54 hasta, kontrol grubunda 39 hasta vardı. KYA gubunda ortalama yaş, kontrol grubuna göre anlamlı olarak daha fazla saptandı (55,4±9,5 yıl, 50,5±9,8 yıl, p=0,019). Trigliserit (TG) seviyesi KYA grubunda kontrol grubuna göre yüksek bulundu (187,3±103,4 mg/dl, 125,3±63,8 mg/dl, p<0,001). Total kolestrolün yüksek yoğunluklu lipoprotein kolestrolüne oranı ...

show abstract

Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Kalaycı¹,

Suleyman²,

Köktürk³

2019

Turkiye Klinikleri J Cardiovasc Sci

View full text Add to dashboard Cite

show abstract

“…LAD artery is the most common coronary artery involved (n = 50), followed by LCX (n = 16) and right coronary artery (RCA) (n = 34) which is similarly reported in other study populations. 8,10 Pontiroli et al 12 in his study population showed that a reduction in BMI after surgical procedures like gastric banding is associated with significant improvement in markers causing endothelial dysfunction, which is the causative factor for CSF phenomenon. BMI is found to be the strongest predictor of coronary slow flow (p = 0.000) in our study population.…”

Section: Discussionmentioning

confidence: 98%

“…Coronary Slow Flow Phenomenon Rao V. as studies by Gökçe et al and Amirzadegan et al 5,[7][8][9][10] show. In a study conducted in the Iranian population with CSF phenomenon, 75% of the patients presented with ACS which is different from our study where CSA is more common.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study

Rao

Garre

2019

Ind J Car Dis Wom

View full text Add to dashboard Cite

Aim This study aimed to analyze laboratory predictors, angiographic profile, clinical profile, and risk factors for coronary slow flow (CSF) phenomenon without coronary obstructive lesion in patients who came for a coronary angiogram. Materials and Methods The case-control study consisted of patients who underwent coronary angiography and were divided into two groups: patients with coronary slow flow (case group, n = 100) and patients with the normal coronary flow (control group, n = 100). Coronary flow was studied using corrected thrombolysis in myocardial infarction frame count (CTFC). The slow flow was defined as CTFC beyond 2 standard deviations from the normal published range. Risk factors including age, sex, diabetes mellitus (DM), hypertension, dyslipidemia, smoking, body mass index (BMI), hematological and biochemical parameters (complete blood picture, platelet count, total and differential leucocyte count, platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR] and lipid profile) were assessed. In both groups, clinical information was collected, and laboratory parameters were measured and compared. Results Patients with CSF were more likely to be male and active smokers. Total cholesterol, triglyceride, BMI, and DM were more commonly seen in the CSF group compared with the control group. Inflammatory markers like uric acid (p = 0.03) and high-sensitivity C-reactive protein (Hs-CRP) (p = 0.000) were found to be statistically significant. Hematocrit (p = 0.023), NLR (p = 0.001), total cholesterol (p = 0.000), triglycerides (p = 0.000), and BMI (p = 0.000) were statistically significant. PLR has the tendency of statistically significance (p = 0.059) BMI, total cholesterol, triglycerides, and Hs-CRP were strong predictors for CSF. Conclusion CSF was common in males, smokers, DM patients, and it was associated with high NLR, uric acid, and Hs-CRP levels. The independent predictor of CSF was BMI, total cholesterol, triglycerides, and Hs-CRP levels. These findings provide an impetus for additional studies to confirm the role of other inflammatory markers in CSF patients and treatment strategies depending on that.

show abstract

“…Pathophysiological inaccuracy leads to no targeted treatment. Previous studies have focused on the search for predictors [3][4][5][6][7] and potential therapeutic approaches [8][9][10], yielded signi cant results and received widespread recognition. Nevertheless, current guidelines do not provide clear treatment recommendations and evaluation procedures for this population, especially after percutaneous coronary intervention (PCI).…”

Section: Introductionmentioning

confidence: 99%

Prognosis Effects of Interventional Therapy on Patients with Coronary Slow Flow: An Observational Cohort Study

Guo

Guan

Tong

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The phenomenon of slow coronary blood flow is common clinically and is related to the patient experiencing repeated chest distress. The mechanism of slow blood flow is still unclear, and the prognosis after combined interventional therapy is unknown. Therefore, we evaluated the role of interventional therapy in this part of the population through the results of a 2-year follow-up.Methods: A total of 4663 patients who underwent continuous coronary angiography (CAG) were identified. Those patients with primary slow coronary flow were included in the study (n=369). The population was then divided into the PCI group and the N-PCI group. CTFT is used to assess the severity of slow blood flow. The endpoint events were the occurrence of rehospitalization and out-of-hospital death within 2 years. The log-rank test, Kaplan-Meier method, and Cox regression were used to evaluate and analyze the final results.Results: A total of 36 patients were readmitted to hospital, and 14 died suddenly outside the hospital during the follow-up period. Among these patients, 6 and 2 patients comprised the PCI group, while 30 and 12 patients comprised the N-PCI group. Comparison of the two groups showed no significant superiority (15.1% vs 13%, P=0.73). In Cox regression analysis, high BMI (body mass index) was an independent predictor of adverse end events (P=0.024).Conclusions: Interventional therapy may not improve outcomes in patients with slow coronary blood flow. BMI plays an important role in the influence of prognosis. Further research is needed to investigate this conclusion.

show abstract

Coronary slow flow phenomenon: Clinical findings and predictors

Cited by 38 publications

References 22 publications

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study

Prognosis Effects of Interventional Therapy on Patients with Coronary Slow Flow: An Observational Cohort Study

Contact Info

Product

Resources

About