Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Abstract

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The association between serum lipid parameters and coronary slow-flow (CSF) phenomenon has been searched previously. The aim of our study was to determine the association between proportional serum lipid parameters and CSF. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We enrolled 93 stable patients randomly who had undergone coronary angiography and had near-normal coronary arteries with normal and slow coronary flow. Demographic, clinical and laboratory data were recorded retrospectively. Coronary flow velocity was evaluated by TIMI frame count (TFC). CFS phenomenon was defined as a TFC greater than 27 frames. Corrected TFC was calculated for the left anterior descending coronary artery. R Re es su ul lt ts s: : Fifty four patients were in CSF group and 39 patients were in control group. The mean age of the patients in CSF group was significantly higher than control group (55.4±9.5 vs. 50.5±9.8 years, p= 0.019). Triglyceride (TG) levels was found higher in CSF group than control group (187.3±103.4 mg/dl, 125.3±63.8 mg/dl, p<0.001). Total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL-c), TG/HDL-c, low density lipoprotein cholesterol to HDL-c ratio (LDL-c/HDL-c) and non-HDL-c levels were significantly higher in CSF group (p=0.007, p=0.004, p=0.044, p=0.018, respectively). TG and TG/HDL-c were found correlated with TFC (r=0.280, r=0.262, respectively). In multivariate logistic regression analysis age, smoking and TG were found statistically significant to predict of CSF. TG was found most associated with the presence of CSF (OR: 7.516, p=0.001). C Co on nc cl lu us si io on n: : Higher TG, TC/HDL-c, TG/HDL-c, LDLc/HDL-c and non-HDL-c levels were related with CSF phenomenon. K Ke ey yw wo or rd ds s: : Dyslipidemia; HDL-triglyceride; triglycerides; coronary slow flow; lipid ratio Ö ÖZ ZE ET T A Am ma aç ç: : Serum lipid parametreleri ve koroner yavaş akım (KYA) fenomeni arasındaki ilişki daha önce araştırılmıştır. Bizim çalışmamızın amacı oransal lipid parametreleri ile KYA arasındaki ilişkiyi araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Biz çalışmaya koroner anjiyografi yapılan ve normale yakın koroner arterleri olan, normal ve yavaş koroner akıma sahip 93 stabil hastayı randomize dahil ettik. Demografik, klinik ve laboratuvar verileri retrospektif olarak yerel veri tabanından bulunarak kaydedildi. Koroner akım velositesi miyokard infarktüsünde tromboliz kare sayısı (TFC) ile değerlendirildi. KYA fenomeni TFC'nin 27 kare üzerinde olması olarak tanımlandı. Sol ön inen koroner arter için düzeltilmiş TFC hesaplandı. B Bu ul lg gu ul la ar r: : KYA grubunda 54 hasta, kontrol grubunda 39 hasta vardı. KYA gubunda ortalama yaş, kontrol grubuna göre anlamlı olarak daha fazla saptandı (55,4±9,5 yıl, 50,5±9,8 yıl, p=0,019). Trigliserit (TG) seviyesi KYA grubunda kontrol grubuna göre yüksek bulundu (187,3±103,4 mg/dl, 125,3±63,8 mg/dl, p<0,001). Total kolestrolün yüksek yoğunluklu lipoprotein kolestrolüne oranı ...

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon

“…The authors concluded that increased TG/HDL-C ratio and low FMD values might indicate endothelial dysfunction and a higher risk of atherosclerosis in these patients. Consistent with previous studies showing a link between low HDL-C and high TG levels and CSFP [32][33][34], we found high TG levels low HDL-C levels in the CSFP group in our study.…”

“…Review of the literature reveals only one retrospective study investigating the relationship between proportional serum lipid parameters and CSFP. In this study including 54 CSFP patients and 39 controls, Kalayci et al [34] found higher TG, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C levels to be associated with CSFP. In addition, there was a weak, but positive correlation between the TG and TG/HDL-C ratio and mean TFC.…”

Plasma Atherogenic Indexes Are Independent Predictors of Slow Coronary Flow

“…The authors stated that age, smoking and TG predict CSF. In the present study, CRI-II was an independent predictor of CSF which was different than Kalaycı et al [34] investigation.…”

“…Fujihara et al [33] demonstrated that CRI-II was an independent predictor of coronary artery stenosis and vulnerable coronary plaque. In a study involving 54 patients with CSF, Kalaycı et al [34] reported that TG/HDL-C ratio, CRI-I and II values were higher in the CSF group than in the control group. The authors stated that age, smoking and TG predict CSF.…”

The Role of AT1R A1166C Gene Polymorphism in Coronary Slow Flow Phenomenon of Undergoing Coronary Angiography Patients

“…The variation of genes encoding functional proteins plays a role in influencing the activity of the RAAS pathway. Several studies have reported that the RAAS gene encoding component is a candidate gene in cardiovascular disease, the presence of RAAS gene polymorphisms associated with coronary artery disease, including CSFP events [15], [16], [17]. The effect of AT1R gene polymorphisms on CSFP events is not yet apparent, and research has limited the influence of AT1R A1166C gene polymorphism on coronary microvascular circulation, which causes CSFP [18], [19], [20], [21].…”