Cornelian cherry consumption increases the l -arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet

Antidiabetic effects of extracts of red and yellow fruits of cornelian cherries (Cornus mas L.) on rats with streptozotocin-induced diabetes mellitus

“…The antioxidant properties of Cornus mas L. fruits have been shown in several other studies using different assay methods. 21,22 In this study, we have investigated the antidiabetic effect of the extract of Cornus mas L. fruits in rats with STZ-induced DM.…”

“…The compounds were administered daily throughout the experimental period. The administration dose and duration were selected based on previous studies 21,22,26 and the content of main compounds, total polyphenols (YC: 326.75 ± 7.12 mg gallic acid equivalent per g, RC: 375.30 ± 4.04 mg gallic acid equivalent per g) and antioxidant activity (YC: 2.65 ± 0.03 01 μmol trolox equivalent per g, RC: 2.83 ± 0.01 μmol trolox equivalent per g) of cornelian cherry extracts from yellow and red fruits.…”

Loganic acid and anthocyanins from cornelian cherry (Cornus mas L.) fruits modulate diet-induced atherosclerosis and redox status in rabbits

“…In our previous studies, we detailed the constituents of cornelian cherry and proved that administering whole lyophilisated fruits diminished atherosclerosis through the same cholesterol-fed rabbit model we used in the present study. 12,14,19 Subsequently, we found that both isolated loganic acid and anthocyanins contributed to the prevention of atherosclerosis, decreasing dislipidemia as well as decreasing the intima thickness and the intima/media ratio in the thoracic aorta of cholesterol-fed rabbits. We also revealed that both substances, especially anthocyanins, increased the expression of PPARs, while only iridoids possessed anti-inflammatory effects.…”

“…Based on our present and previous studies, possible indications for cornelian cherry and its isolated constituents include dyslipidemia and atherosclerosis. 12,14,19 Whole dried or lyophilisated fruits may be used as a functional food in patients treated with a diet and lifestyle modifications alone. Isolated components or extracts may be used as phytopharmaceuticals in patients treated with statins.…”

The Effects of Natural Iridoids and Anthocyanins on Selected Parameters of Liver and Cardiovascular System Functions

“…Moreover, it decreases intima thickness and the intima/media ratio in the thoracic aorta. Cornelian cherry compounds have a substantial protective effect on oxidative stress in the liver and causes a vital enhancement of PPAR-alpha and PPAR-gamma expression in the liver [47][48][49][50]. In turn, clinical trials in diabetic type 2 and hyperlipidemic patients showed a significant improvement of the sugar level and insulin secretion in diabetic patients and an amelioration of the lipid profile, apolipoprotein status, and vascular inflammation in hyperlipidemic patients.…”