Loganic acid and anthocyanins from cornelian cherry (Cornus mas L.)
fruits modulate diet-induced atherosclerosis and redox status in rabbits

Sozański, Tomasz; Kucharska, Alicja Z.; Dzimira, Stanisław; Magdalan, Jan; Szumny, Dorota; Matuszewska, Agnieszka; Nowak, Beata; Piórecki, Narcyz; Szeląg, Adam; Trocha, Małgorzata

doi:10.17219/acem/74638

Cited by 25 publications

(16 citation statements)

References 31 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The previous findings [ 4 , 22 , 23 , 24 ] showed that cornelian cherry fruits are a prospectively valuable source of chemicals that can play an exploitable role in preventing adverse changes in the cardiovascular system, including the aorta and also the liver. However, the impact of cornelian cherry’s iridoids and anthocyanins on transcription factors that play an important role in lipid and cholesterol metabolism, and also on many serum parameters crucial in the development and diagnostics of cardiovascular and liver diseases, is not fully explored.…”

Section: Introductionmentioning

confidence: 99%

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model

et al. 2021

Self Cite

View full text Add to dashboard Cite

Cornelian cherry (Cornus mas L.) fruits possess potential cardiovascular, lipid-lowering and hypoglycemic bioactivities. The aim of this study is to evaluate the influence of resin-purified cornelian cherry extract rich in iridoids and anthocyanins on several transcription factors, intima/media ratio in aorta and serum parameters, which determine or are valuable indicators of the adverse changes observed in the course of atherosclerosis, cardiovascular disease, and metabolic syndrome. For this purpose, male New Zealand rabbits were fed a diet enriched in 1% cholesterol for 60 days. Additionally, one group received 10 mg/kg b.w. of cornelian cherry extract and the second group 50 mg/kg b.w. of cornelian cherry extract. PPAR-α and PPAR-γ expression in the aorta, LXR-α expression in the liver; cholesterol, triglycerides, adipokines, apolipoproteins, glucose and insulin levels in serum; the intima and media diameter in the thoracic and abdominal aorta were determined. Administration of cornelian cherry extract resulted in an enhancement in the expression of all tested transcription factors, a decrease in triglycerides, leptin and resistin, and an increase in adiponectin levels. In addition, a significant reduction in the I/M ratio was observed for both the thoracic and abdominal aorta. The results we have obtained confirm the potential contribution of cornelian cherry extract to mitigation of the risk of developing and the intensity of symptoms of obesity-related cardiovascular diseases and metabolic disorders such as atherosclerosis or metabolic syndrome.

show abstract

Section: Introductionmentioning

confidence: 99%

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, Sozanski [21] reported protective effects of CC on diet-induced hypertriglyceridemia and atherosclerosis through regulation of oxidative stress in rabbits [21]. In another study, Sozanski et al [26] documented that iridoids and anthocyanins from cornelian cherry fruits reduced formation of atherosclerotic plaques in the aorta of cholesterol-fed rabbits. Again, decreased oxidative stress determined as an increase of GSH and attenuated lipid peroxidation measured as malondialdehyde concentrations were responsible for this beneficial effect [26].…”

Section: Discussionmentioning

confidence: 93%

“…In another study, Sozanski et al [26] documented that iridoids and anthocyanins from cornelian cherry fruits reduced formation of atherosclerotic plaques in the aorta of cholesterol-fed rabbits. Again, decreased oxidative stress determined as an increase of GSH and attenuated lipid peroxidation measured as malondialdehyde concentrations were responsible for this beneficial effect [26]. Similarly, Alavian et al [27] showed reduced lipid peroxidation after CC treatment in CCl4-induced hepatotoxicity in rats [27].…”

Section: Discussionmentioning

confidence: 97%

Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10

et al. 2020

View full text Add to dashboard Cite

Cornelian cherries (CCs) belong to promising anti-obesity substances. We aimed to study effects of coenzyme Q10 (CoQ10) and two varieties of CCs on lipid profile, ROS, and nitric oxide (NO) production in obese rats. Male Zucker rats were divided into the control group and groups treated with CoQ10 (30mg/kg/day), or CC varieties: Koralovij Marka (KM) and Wild Type (WT) (5 g/kg/day, n = 6 in each group) for 6 weeks. Blood pressure (BP), bodyweight, relative heart weight, and plasma lipid profile were determined. NOS activity and expressions of eNOS, SOD, and NADPH oxidase were determined in the left ventricle (LV) and aorta. Among CC groups, KM decreased bodyweight and WT relative heart weight. Neither CoQ10 nor CCs affected BP. CoQ10 did not affect lipid profile and NOS activity either in the LV or aorta. On the other hand, WT decreased cholesterol and LDL levels. KM and WT increased NOS activity in the aorta, while not affecting the activity in the LV. KM increased eNOS expression and did not affect ROS production, while WT increased SOD and decreased NADPH oxidase without affecting eNOS expressions in both tissues. In conclusion, CCs showed better beneficial effects than CoQ10 in all parameters studied.

show abstract

“…In vitro experiments also indicate that cyanidin-3-O-β-glucoside inhibits NOS protein and mRNA expression and hence reduces nitric oxide overproduction [104]. In vitro studies also demonstrate that cyanidin-3-O-β-glucoside inhibits NOS [105], lipopolysaccharideinduced, and COX-2 expression and hence reduces nitric oxide overproduction [106]. Anthocyanin-containing cornelian cherry helps avoid fed-induced atherosclerosis, and the ingestion of fruit containing in these mixtures can have beneficial implications on the cardiovascular system [107].…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 90%

Metabolism of Anthocyanins and Modulation of Gut Microbiome in Inflammatory Bowel Disease

Alnadari¹,

Abdin²,

Ennab³

et al. 2020

J Food Chem Nanotechnol

View full text Add to dashboard Cite

Anthocyanins are pigments extracted from different plant parts with a great ability to scavenge anti-inflammatory activity and free radicals. The anthocyanin ingestion promotes the synthesis of gut microbiome and host cells. The anthocyanin metabolism shows large variability between individuals. Inter-individual disparities in the metabolites of anthocyanin could modify the development of particular intestinal bacteria. Pre-clinical trials have ascertained that there was a great correlation between anthocyanin consumption and modification of intestinal immune function. This paper sums up the literature on the useful roles of anthocyanin-rich nutrients in the medication and prevention of inflammatory bowel diseases. This takes into account the modification of the gut microbiome and microorganisms produced. Thus, this review would pave the way for natural remedies for human chronic and intestinal diseases during understanding the uses and mechanisms of anthocyanins.

show abstract

Loganic acid and anthocyanins from cornelian cherry (Cornus mas L.) fruits modulate diet-induced atherosclerosis and redox status in rabbits

Abstract: We have shown that both iridoids and anthocyanins help prevent fed-induced atherosclerosis, and the consumption of fruits rich in these substances may elicit beneficial effects on the cardiovascular system.

Cited by 25 publications

References 31 publications

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α Expression and Alters Adipokines and Triglycerides Levels in Cholesterol-Rich Diet Rabbit Model

Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10

Metabolism of Anthocyanins and Modulation of Gut Microbiome in Inflammatory Bowel Disease

Contact Info

Product

Resources

About