Beneficial Effects of Cornelian Cherries on Lipid Profile and NO/ROS Balance in Obese Zucker Rats: Comparison with CoQ10

Abstract

Cornelian cherries (CCs) belong to promising anti-obesity substances. We aimed to study effects of coenzyme Q10 (CoQ10) and two varieties of CCs on lipid profile, ROS, and nitric oxide (NO) production in obese rats. Male Zucker rats were divided into the control group and groups treated with CoQ10 (30mg/kg/day), or CC varieties: Koralovij Marka (KM) and Wild Type (WT) (5 g/kg/day, n = 6 in each group) for 6 weeks. Blood pressure (BP), bodyweight, relative heart weight, and plasma lipid profile were determined. NOS activity and expressions of eNOS, SOD, and NADPH oxidase were determined in the left ventricle (LV) and aorta. Among CC groups, KM decreased bodyweight and WT relative heart weight. Neither CoQ10 nor CCs affected BP. CoQ10 did not affect lipid profile and NOS activity either in the LV or aorta. On the other hand, WT decreased cholesterol and LDL levels. KM and WT increased NOS activity in the aorta, while not affecting the activity in the LV. KM increased eNOS expression and did not affect ROS production, while WT increased SOD and decreased NADPH oxidase without affecting eNOS expressions in both tissues. In conclusion, CCs showed better beneficial effects than CoQ10 in all parameters studied.

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

“…One of diabetes symptoms is a decrease in body weight caused by insulin resistance and impairment in whole-body glucose uptake. Dayar et al [ 35 ] also observed non-significant impact of wild type Cornelian cherries administration (5 g/kg/day for six weeks) on the body weight in obese Zucker rats. Our study seems to be the first evaluating the effect of Cornelian cherry pulp on femoral weight and length.…”

Protective Effects of Polyphenols against Ischemia/Reperfusion Injury

“…Table 1 provides examples of these bioactive compounds along with their host foods [81][82][83][84][85][86][87]. The structural diversity between flavonoid subgroups produces different beneficial properties, such as antioxidant, anti-inflammatory, anti-diabetic, and/or antithrombotic activities [88][89][90][91]. In general, more than two-thirds of the polyphenols consumed in one's diet are flavonoids.…”

Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

“…Furthermore, the cornelian cherry that contains a high amount of polyphenols has anti-atherosclerotic properties mainly based on its ability to curtail the inflammation process and improve endothelial dysfunction [ 59 ]. Dayar et al [ 156 ] documented that different types of cornelian cherries have better beneficial effects than the powerful antioxidant coenzyme Q10 in obese Zucker rats. In contrast to coenzyme Q10, cornelian cherries decreased cholesterol, LDL levels, and ROS production, while increasing eNOS activity/expression [ 156 ].…”

“…Dayar et al [ 156 ] documented that different types of cornelian cherries have better beneficial effects than the powerful antioxidant coenzyme Q10 in obese Zucker rats. In contrast to coenzyme Q10, cornelian cherries decreased cholesterol, LDL levels, and ROS production, while increasing eNOS activity/expression [ 156 ]. In a randomized controlled trial, Chai et al [ 157 ] showed that tart cherries can lower the systolic blood pressure and LDL cholesterol levels in older adults.…”