Corneal Endothelial Permeability after Anterior Chamber Silicone Oil

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Cytotoxicity of silicone oil on cultivated human corneal endothelium

“…Animal studies also showed corneal changes only in days after the injection of silicone oil in anterior chamber. 15,16 These evidences indicated a possibility of direct toxic effect of silicone oil on CE when they contact. In addition, toxic impurities, the low-molecular-weight ingredients in silicone oil, have been reported to be toxic to CE and may contribute to this toxicity of silicone oil.…”

Passive Removal of Silicone Oil with Temporal Head Position through Two 23-Gauge Cannulas

“…Previous studies reported that residual silicone oil may cause keratopathy [ 7 ] and secondary glaucoma [ 6 ] and even migrate along the intracranial portion of the optic nerve and into the lateral ventricles of the brain [ 9 ]. Therefore, complete removal of silicone oil is important.…”

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Cytotoxicity of silicone oil on cultivated human corneal endothelium

“…Animal studies also showed corneal changes only in days after the injection of silicone oil in anterior chamber. 15,16 These evidences indicated a possibility of direct toxic effect of silicone oil on CE when they contact. In addition, toxic impurities, the low-molecular-weight ingredients in silicone oil, have been reported to be toxic to CE and may contribute to this toxicity of silicone oil.…”

Passive Removal of Silicone Oil with Temporal Head Position through Two 23-Gauge Cannulas

“…Previous studies reported that residual silicone oil may cause keratopathy [ 7 ] and secondary glaucoma [ 6 ] and even migrate along the intracranial portion of the optic nerve and into the lateral ventricles of the brain [ 9 ]. Therefore, complete removal of silicone oil is important.…”

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Cytotoxicity of silicone oil on cultivated human corneal endothelium

“…Animal studies also showed corneal changes only in days after the injection of silicone oil in anterior chamber. 15,16 These evidences indicated a possibility of direct toxic effect of silicone oil on CE when they contact. In addition, toxic impurities, the low-molecular-weight ingredients in silicone oil, have been reported to be toxic to CE and may contribute to this toxicity of silicone oil.…”

Passive Removal of Silicone Oil with Temporal Head Position through Two 23-Gauge Cannulas

“…Previous studies reported that residual silicone oil may cause keratopathy [ 7 ] and secondary glaucoma [ 6 ] and even migrate along the intracranial portion of the optic nerve and into the lateral ventricles of the brain [ 9 ]. Therefore, complete removal of silicone oil is important.…”