Corneal Endothelial Permeability after Anterior Chamber Silicone Oil

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Cytotoxicity of silicone oil on cultivated human corneal endothelium

“…Animal studies also showed corneal changes only in days after the injection of silicone oil in anterior chamber. 15,16 These evidences indicated a possibility of direct toxic effect of silicone oil on CE when they contact. In addition, toxic impurities, the low-molecular-weight ingredients in silicone oil, have been reported to be toxic to CE and may contribute to this toxicity of silicone oil.…”

“…8,12 Evidence showed the silicone oil penetration into ocular tissues including the anterior segments, and although no massive inflammation has been detected in the zones in contact with silicone oil, immunoglobulins and complement fractions are present in the stroma and around the droplets of emulsified silicone oil, suggesting a local immune reaction. 14 Furthermore, injection of silicone oil into rabbit's anterior chamber causes the changes in CE morphology and permeability; 15,16 these evidences indicated the possible cytotoxic effects of silicone oil on CEs rather than just acting as a barrier of cell nutrition.…”

Evaluation of limbal and pars plana silicone oil removal in aphakic eyes

“…On the one hand, the subset of aphakic patients with silicone oil endotamponade requiring SOR is relatively infrequent; on the other hand, our inclusion criteria additionally dropped out several patients from the study. The rationale to exclude eyes with silicone oil touch was to minimize the bias because in these eyes the corneal endothelium is considerably more compromised (Sternberg et al 1985;Yang et al 2008;Versura et al 2001;Norman et al 1990). The limitation of the experimental part of the study is the in vitro setting which only conditionally addresses the clinical situation.…”