Cytotoxicity of silicone oil on cultivated human corneal endothelium

Abstract

Background and Objective To

Deep Anterior Lamellar Corneal Dissection To Improve Visualization During Vitreoretinal Surgery

“…It cannot be used, however, in cases of recent penetrating axial and para-axial corneal wounds. It is known that combined penetrating keratoplasty (PKP) with retinal detachment repair increases the risks of graft failure and that silicone oil 6,8 and heavy liquid are toxic to the cornea and associated with corneal decompensation and band-shaped keratopathy-performing the retinal reattachment surgery first and removing oil tamponade before corneal grafting will maximize the chances of graft survival. Autokeratoplasty can be used after KTP surgery; however, avoiding full-thickness corneal surgery prevents the distortion to surgical anatomy associated with this procedure and also prevents potential iris synechiae 9 formation both of which are associated with later graft failure.…”

Silicone oil pupil block glaucoma in a pseudophakic eye

“…Corneal oedema results from a loss of corneal deturgescence due to increased hydrostatic pressure from the aqueous and/or corneal endothelial dysfunction 9. Silicone oil is directly toxic to endothelial cells, and prevents diffusion of nutrients through aqueous displacement 9.…”

“…Silicone oil is directly toxic to endothelial cells, and prevents diffusion of nutrients through aqueous displacement 9. Long-term anterior chamber silicone oil can result in permanent corneal decompensation requiring penetrating or endothelial keratoplasty 10–12.…”

Management of Intraoperative and Postoperative Complications During Vitrectomy for Retinal Detachment

“…The keratopathy is thought to result from pH changes caused by reduced fl ow across the cornea [ 27 ]. The higher viscosity (5,000 centistoke) silicone oil suppressed cell cycling signifi cantly more than the lower viscosity (1,000 centistoke) silicone oil [ 28 ].…”