Corneal Cell Morphology in Keratoconus: A Confocal Microscopic Observation

Ghosh, Somnath; Mutalib, Haliza Abdul; Kaur, Sharanjeet; Ghoshal, Rituparna; Retnasabapathy, Shamala

doi:10.21315/mjms2017.24.2.6

Cited by 10 publications

(9 citation statements)

References 28 publications

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“…It is very difficult to found any abnormal of cornea by slit lamp in the stage of preclinical stage of keratoconus. Some research mentioned the fold near Descement membrane [16][17][18]. In our study we found black fold near Descement membrane in almost all eyes, especially in patients with keratoconus.…”

Section: Discussionsupporting

confidence: 57%

Cornea Confocal Microscopy Study of Patients with Preclinical Keratoconus

Yang¹,

Wu²,

Wu³

et al. 2022

IJOVS

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Purpose: To report the difference of corneal confocal microscopy examination in patients with preclinical keratoconus or clinical keratoconus. Methods: 8 unilateral keratoconus patients were examined by confocal microscopy before they had cross-linking surgery. As control groups, 23 patients with myopia and 13 patients with keratoconus in both eyes were also examined by confocal microscopy. Then we used Image J to compared the density of epithelium cell, length of cornea nerve fiber, density of Langerhans cell, density of keratocyte in shallow, middle, deep stroma, and the width and grayscale value of fold near Descement membrane for each group. Result: There was differences in corneal epithelial cell count between three groups (4358.27 ± 635.14 cells/mm 2 versus 4057.81 ± 316.29 cells/mm 2 versus 3522.65 ± 978.10 cells/mm 2 ). The density of keratocyte in stroma showed a tendency to decrease with increasing depth. The density of keratocyte in keratoconus was less than that in normal eyes. The fold showed much wider and daker in keratoconus eyes than in normal eyes. The density of Langerhans cell was more in keratoconus group than it in normal group. Conclusion: We first report the differences in corneal epithelial cell count and fold near Descement membrane. It might provide a new way to diagnose early keratoconus. The difference of density of Langerhans cell suggested us the possibility of inflammation in keratoconus.

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Section: Discussionsupporting

confidence: 57%

Cornea Confocal Microscopy Study of Patients with Preclinical Keratoconus

Yang¹,

Wu²,

Wu³

et al. 2022

IJOVS

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“…All corneal layers show histopathological structural changes in KC (Khaled et al 2017). Studies have shown that basal epithelial cells in KC patients displayed enlargement, irregular arrangement, and a significant reduction in cell density when compared to healthy individuals (Ghosh et al 2017). Other studies demonstrated either no significant change of corneal epithelium (Erie et al 2002) or thickened corneal epithelium in KC patients (Hollingsworth et al 2005;Weed et al 2007;Bitirgen et al 2015).…”

Section: Clinical Aspects Of Injury and Diseasementioning

confidence: 98%

Corneal injury: Clinical and molecular aspects

Barrientez

Nicholas

Whelchel

et al. 2019

Experimental Eye Research

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Currently, over 10 million people worldwide are affected by corneal blindness. Corneal trauma and disease can cause irreversible distortions to the normal structure and physiology of the cornea often leading to corneal transplantation. However, donors are in short supply and risk of rejection is an ever-present concern. Although significant progress has been made in recent years, the wound healing cascade remains complex and not fully understood. Tissue engineering and regenerative medicine are currently at the apex of investigation in the pursuit of novel corneal therapeutics. This review uniquely integrates the clinical and cellular aspects of both corneal trauma and disease and provides a comprehensive view of the most recent findings and potential therapeutics aimed at restoring corneal homeostasis.

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“…On the other hand, Ghosh and his colleagues demonstrated that, the corneal cell morphology of cases with KC varied significantly from the healthy ones except in ECD (P=0.072) (17) .…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Corneal Endothelial Changes and Corneal Tomographic Parameters in Eyes with Keratoconus

Abdelrahman

Kamel

Elkhouly

et al. 2021

Egyptian Journal of Ophthalmology, (Mansoura Ophthalmic Center)

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Purpose: To evaluate changes in corneal endothelium and its correlation with tomographic parameters in different stages of keratoconus (KC). Methods:This study was conducted on 95 eyes of 70 patients with KC (underwent Visian ICL V4c implantation) attending to Mansoura ophthalmic center and 40 normal controls with matching age and sex in the period from April 2018 till May 2019. All individuals were subjected to full history and ocular examination. In addition Oculus pentacam was performed to diagnose KC, grades and assessment of Keratometry, thickness at the apex, thinnest corneal thickness and Anterior and Back elevation, while Specular microscopy was performed to assess the endothelial cell counting, Coefficient of variation (C/V) and Hexagonal cell ratio.Results: There were highly statistically significant differences among KC cases and the control group as regards endothelial count, C/V and hexagonal cell ratio. In addition such changes had a positive correlation with the degree of KC. Conclusion:There were significant corneal endothelial changes as well as Corneal Tomographic alterations among eyes with KC compared to normal ones and these changes have a positive correlation with the severity of KC. Specular microscopic examinations in patients with KC provide important data in addition to topography.

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Corneal Cell Morphology in Keratoconus: A Confocal Microscopic Observation

Cited by 10 publications

References 28 publications

Cornea Confocal Microscopy Study of Patients with Preclinical Keratoconus

Cornea Confocal Microscopy Study of Patients with Preclinical Keratoconus

Corneal injury: Clinical and molecular aspects

Evaluation of Corneal Endothelial Changes and Corneal Tomographic Parameters in Eyes with Keratoconus

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