Evaluation of Corneal Endothelial Changes and Corneal Tomographic Parameters in Eyes with Keratoconus

Abstract

Purpose: To evaluate changes in corneal endothelium and its correlation with tomographic parameters in different stages of keratoconus (KC). Methods:This study was conducted on 95 eyes of 70 patients with KC (underwent Visian ICL V4c implantation) attending to Mansoura ophthalmic center and 40 normal controls with matching age and sex in the period from April 2018 till May 2019. All individuals were subjected to full history and ocular examination. In addition Oculus pentacam was performed to diagnose KC, grades and assessment of Keratometry, thickness at the apex, thinnest corneal thickness and Anterior and Back elevation, while Specular microscopy was performed to assess the endothelial cell counting, Coefficient of variation (C/V) and Hexagonal cell ratio.Results: There were highly statistically significant differences among KC cases and the control group as regards endothelial count, C/V and hexagonal cell ratio. In addition such changes had a positive correlation with the degree of KC. Conclusion:There were significant corneal endothelial changes as well as Corneal Tomographic alterations among eyes with KC compared to normal ones and these changes have a positive correlation with the severity of KC. Specular microscopic examinations in patients with KC provide important data in addition to topography.