Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects

Abstract

PurposeThe aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs).MethodsTwo thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm. The DCRs assessed were Deformation Amplitude (DA) Applanation 1 velocity (A1v), integrated radius (1/R), deformation amplitude ratio (DAratio), stiffness parameter at applanation 1 (SPA1), ARTh (Ambrósio's Relational Thickness to the horizontal profile), and the novel Stress Strain Index (SSI).ResultsAfter age-, CCT-, and IOP- matching, 503 Chinese were assigned to 452 Caucasians participants. Statistical analysis showed a statistical significant difference between Chinese and Caucasian Healthy subjects in the values of SPA1 (p = 0.008), Arth (p = 0.008), and SSI (p < 0.001). Conversely, DA, A1v, DAratio, and 1/R were not significantly different between the two ethnical groups (p > 0.05).ConclusionWe found significant differences in the values of the DCRs provided by the Corvis ST between Chinese and Caucasian healthy subjects.

Comparison of Ectasia Detection in Early Keratoconus Using Scheimpflug-Based Corneal Tomography and Biomechanical Assessments

“…A recently published study has highlighted that biomechanical differences are demonstrated between White and Chinese eyes, and to the authors' knowledge, no previous study has investigated the sensitivity of biomechanical indices in detecting subclinical keratoconus in a South Pacific population where M aori and Pacific Peoples have a high prevalence of keratoconus. 18,19 The current study is in agreement with the previous studies investigating the TBI, finding an AUROC of 1.00 (95% CI = 0.99-1.00) for normal versus VAE-E corneas and an AUROC of 0.92 (95% CI = 0.86-0.98) when distinguishing between healthy and VAE-NT corneas. The TBI was not statistically superior to the CBI or the BAD-D in distinguishing between normal and VAE-E corneas, and this likely reflects that all 3 metrics are suitable for this purpose.…”

“…A recently published study has highlighted that biomechanical differences are demonstrated between White and Chinese eyes, and to the authors’ knowledge, no previous study has investigated the sensitivity of biomechanical indices in detecting subclinical keratoconus in a South Pacific population where Māori and Pacific Peoples have a high prevalence of keratoconus. 18,19…”

Effect of myopia and astigmatism deepening on the corneal biomechanical parameter stress-strain index in individuals of Chinese ethnicity

“…Recent studies have demonstrated the good repeatability of SSI in eyes of different CCT and in myopic eyes ( Wang et al, 2021 ; Lu et al, 2022 ). However, SSI values may differ among races ( Chua et al, 2017 ; Vinciguerra et al, 2022 ). Liu et al reported that the SSI was relatively stable before 35 years of age and was positively correlated with anterior corneal curvature and IOP and negatively correlated with axial length (AL) in a healthy Chinese population ( Liu et al, 2020 ).…”

Change in the corneal material mechanical property for small incision lenticule extraction surgery

“…Additionally, topical PG therapy reduced corneal stiffness, suggesting that the ocular hypotensive effect of these drugs is overestimated if we measure IOP with Goldman Applanation Tonometry (GAT) instead of bIOP. Because SSI can truly reflect the differences in material properties, one study ( Vinciguerra et al, 2022 ) evaluated the difference between Caucasian and healthy Chinese subjects in Corvis ST dynamic corneal response parameters and found a significant difference in SSI values.…”