Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in experimental rats via AGEs inhibition

Abstract

Inthe present study, we have demonstrated the phytochemical composition of petroleum ether extract of C . sativum (CPE) seeds by using chromatographic, spectroscopic as well spectrometric analysis. CPE was evaluated for its possible role in mitigation of diabetic nephropathy (DN) in Streptozotocin (STZ)-nicotinamide (NAD) induced type 2 diabetes model. Administration of CPE at doses of 100, 200, and 400 mg/kg for 45 days has produced significant attenuation of elevated biochemical parameters including serum glucose, lipid and creatinine levels. CPE has also reserved albuminuria and elevated creatinine clearance in treated diabetic rats. Advanced glycation end products (AGEs) formation in kidneyswas also considerably reduced along with noteworthy increase in level of superoxide dismutase (SOD), glutathione (GSH), and decrease in lipid peroxidation in terms of thiobarbituric acid reactive species (TBARS). Molecular docking studies were also employed to reveal out the possible mechanism. In conclusion, using STZ-NAD model, we have successfully predicted that by assets of bioactive constituents CPE might inhibit the progression of DN. C . sativum may act as potential adjuvant for antidiabetic therapy and needs to be investigated further.

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

“… The role of C. sativum phytochemicals in some of its biological activities from different studies ① Suttisansanee, Thiyajai, Chalermchaiwat, Wongwathanarat, Pruesapan, Charoenkiatkul and Temviriyanukul [ 72 ], ② Kajal and Singh [ 73 ], ③ Hajlaoui, Arraouadi, Noumi, Aouadi, Adnan, Khan, Kadri and Snoussi [ 75 ], ④ Hajlaoui, Arraouadi, Noumi, Aouadi, Adnan, Khan, Kadri and Snoussi [ 75 ], ⑤ Cha, Yoon, Kim, Kim and Lee [ 76 ], and ⑥ Ramadan, et al [ 77 ]. …”

“…In the same study, the angiotensin-converting enzyme was inhibited by coriander extracts to 70.66 ± 2.34% which shows that the polyphenolic-rich extract can be beneficial for hypertension in vitro. Moreover, the diabetic nephropathy prevention and hypolipidemic activities were illustrated in the petroleum ether extract of C. sativum seeds that are rich in linalool, ascorbyl palmitate, and petroselinic acid [ 73 ]. The saturation of hexokinase enzymes due to diabetes leads to the formation of advanced glycation end products (AGEs), which when interacting with their receptors cause vascular aging and renal damage [ 74 ].…”

Interactive Effect of Seeds of Coriandrum Sativum L. With Glimepiride in Streptozotocin-Induced Diabetic Rats

“…The Seed extract of C. sativum contain terpenoids, the terpene and terpenoids are well known for reducing oxidative stress, hyperglycemia, hyper lipidemia, and for secreting insulin. So combination therapy shows significant effect than alone 29 . Moreover, the presence of various bioactive phytoconstituents like flavonoids, saponins and terpenoids may played a wide role in this contribution which comes in consistent with previous findings which stated that these phytochemicals are the potential insulin regenerators by various molecular mechanisms.…”

Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

“…[17] Coriandrum sativum Apiaceae Coriander Seed Delayed progression of DN, by inhibiting AGE. [18] Ocimum sanctum Labiatae Tulasi Leaves Antioxidant and anti-inflammatory activity. [19] Pterocarpus santalinus Fabaceae Red sandalwood Bark Antioxidant activity.…”