Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair

Chang, Po-Chun; Tai, Wei‐Chiu; Luo, Huiting; Lai, Chung-Sheng; Lin, Hsu-Hsiang; Lin, Zhisheng; Chang, Ying-Chieh; Lee, Bor-Shiunn

doi:10.1016/j.ijbiomac.2020.04.183

Cited by 16 publications

(7 citation statements)

References 38 publications

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“…CS is one of the most used polysaccharides for the preparation of nanoparticles, having the advantage of an intrinsic antibacterial activity [ 91 ]. It is often used in combination with alginates [ 100 , 101 ] or with PLGA [ 103 , 104 , 105 ], associated with the collagen matrix [ 97 ], in the form of derivatives [ 97 , 98 ] or biocomposites.…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

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Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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Section: Polymer–drug Systemsmentioning

confidence: 99%

“…Cellulose derivatives (CAP, HPMC, MC) [ 105 , 106 ] or other polysaccharides (sodium alginate) [ 102 ] are reported in recent literature.…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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“…Due to high healing properties, hyaluronic acid is also used in topical administration as well as in coadjutant treatment for chronic and acute gingival and dental diseases. It may also be used for aesthetics to increase the lip volume (facial features) and restore gingival papillae when they are damaged [ 76 , 77 ]. On the other hand, the scaffolds based on HA were considered useless in pulp and dentine regeneration due to their poor mechanical properties and rapid degradation [ 67 ].…”

Section: Oral Applications Of Natural Polymersmentioning

confidence: 99%

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Paradowska-Stolarz

Więckiewicz

Owczarek

et al. 2021

IJMS

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The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

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“…Core-shell NPs of PolyD-L-lactide-co-glycolide (PLGA) coated with chitosan (CS) have an excellent safety profile, good biocompatibility, low levels of immunogenicity and toxicity and tunable in vivo biodegradation rate [ 10 , 11 ]. Moreover, PLGA and CS have been approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) as effective carriers for drug delivery in humans [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of 18-β-Glycyrrhetinic Acid from Core-Shell Nanoparticles: Effects on Cytotoxicity and Intracellular Concentration in HepG2 Cell Line

et al. 2021

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18β-glycyrrhetinic acid (GA) is a pentacyclic triterpene with promising hepatoprotective and anti-Hepatocellular carcinoma effects. GA low water solubility however reduces its biodistribution and bioavailability, limiting its applications in biomedicine. In this work we used core-shell NPs made of PolyD-L-lactide-co-glycolide (PLGA) coated with chitosan (CS), prepared through an osmosis-based methodology, to efficiently entrap GA. NPs morphology was investigated with SEM and TEM and their GA payload was evaluated with a spectrophotometric method. GA-loaded NPs were administered to HepG2 cells and their efficiency in reducing cell viability was compared with that induced by the free drug in in vitro tests. Cell viability was evaluated by the MTT assay, as well as with Electric Cells-Substrate Impedance Sensing (ECIS), that provided a real-time continuous monitoring. It was possible to correlate the toxic effect of the different forms of GA with the bioavailability of the drug, evidencing the importance of real-time tests for studying the effects of bioactive substances on cell cultures.

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Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair

Cited by 16 publications

References 38 publications

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Controlled Release of 18-β-Glycyrrhetinic Acid from Core-Shell Nanoparticles: Effects on Cytotoxicity and Intracellular Concentration in HepG2 Cell Line

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