Cord blood galectin-1 and -3 concentrations in term pregnancies with normal restricted and increased fetal growth

Abstract

Lower UC gal-1 levels, when mothers were older, and increased UC gal-3 levels in cases of gestational diabetes, possibly reflect angiogenic activity. In multiparas, decreased MS gal-3 and UC gal-1 levels in IUGR/LGA, respectively, might imply inflammatory response against immunosuppression expected in subsequent pregnancies, as compared to the first one.

Association of circulating galectin‐3 with gestational diabetes mellitus, progesterone, and insulin resistance

“…In a small sample size study, cord blood galectin-3 levels were found to reach the highest level in mothers presenting with GDM (delivering large-for-gestational-age babies). 3 Galectin-3 is a protein expressed in multiple cell types and can be secreted into extracellular fluid as a soluble protein. 4 It has multiple functions including modulation of cell adhesion, differentiation, proliferation, and the promotion of inflammation.…”

Galectin-3: An Early Marker of Gestational Diabetes, Subclinical Atherosclerosis, and Tumor Progression

“…We evaluated galectin-1 and galectin-3 levels in term pregnancies with normal, intrauterine growth restricted, and large-for-gestational-age neonates and their mothers. 2 Galectin-3 levels were increased when mothers presented with gestational diabetes. 2 Elevated galectin-3 levels in these women have implications in placental angiogenesis since galectin-3 is a potent angiogenic factor involved in embryogenesis.…”

“…2 Galectin-3 levels were increased when mothers presented with gestational diabetes. 2 Elevated galectin-3 levels in these women have implications in placental angiogenesis since galectin-3 is a potent angiogenic factor involved in embryogenesis. 3 The increased placental angiogenesis may explain why women with gestational diabetes deliver large-for-gestational-age neonates.…”

“…3 The increased placental angiogenesis may explain why women with gestational diabetes deliver large-for-gestational-age neonates. 2…”

Editorial

“…Further studies worked out the association between maternal omentin levels and insulin resistance and tried to find out the source of omentin in maternal circulation [6] and galectin concentrations in cord blood of pregnancies with normal restricted and increased fetal gowth [7]. Bonongwe et al report a retrospective study from a South African Hospital on screening for gestational diabetes [8], and finally Koh et al examine the consequences that cesarean sections might have on cord blood glucose levels [9].…”