CoQ10 and L-Carnitine Attenuate the Effect of High LDL and Oxidized LDL on Spermatogenesis in Male Rats

Ghanbarzadeh, Saeed; Garjani, Alireza; Ziaee, Mojtaba; Khorrami, Arash

doi:10.1055/s-0033-1361176

Cited by 17 publications

(20 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 Both sperm progressive motility and total motility were significantly higher in infertile patients after 3 months of antioxidant treatment. Our findings are consistent with previous studies which demonstrated higher sperm motility in patients with idiopathic infertility following vitamin C, 23 vitamin E, 3,18,20 zinc, 10,18,24 selenium, 3,18 and coenzyme Q10 8,18,25 administration. A recent study has compared the effect of L-carnitine vs a combination of zinc, vitamin E, selenium, coenzyme Q10, glutathione, and L-carnitine and reported improvement in all seminal fluid measures after 3 months of combined treatment.…”

Section: Discussionsupporting

confidence: 93%

“…However, during pathological conditions, when generation of ROS is exceeded, the balance between free radical production and the protective antioxidant defence system shifted to the increase in free radicalmediated oxidative stress. 8 Moreover, many studies have revealed that the antioxidant capacity of seminal fluid is suppressed in infertile men in comparison with fertile men. 6,9 Based on the integral role of oxidative stress in the pathogenesis of male infertility, treatment strategies that target the reduction of seminal oxidative stress have become a probable therapeutic window to improve reproduction potential and pregnancy rates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar¹

2017

International Journal of Infertility &Amp; Fetal Medicine

View full text Add to dashboard Cite

Introduction: Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertil ity and recently antioxidants have been tried to treat men with idiopathic infertility. Objective: To assess the effect of treatment with vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 on seminal fluid parameters in infertile men with idiopathic oligoasthenozoo spermia. Materials and methods: A prospective randomized trial was conducted on 32 infertile men with idiopathic oligoasthenozoo spmia who received a daily supplement of one caplet contain ing vitamin C (90 mg/day), vitamin E (15 mg/day), coenzyme Q10 (4 mg/day), selenium (30 µg/day), and zinc (5 mg/day) for 3 months. Semen analysis was performed at baseline and 3 months after treatment using World Health Organization (WHO) 2010 guidelines. Results: Significant improvement in sperm concentration was observed after combination therapy (9.13 ± 4.29 vs 11.3 ± 6.05 × 10 6 /mL, p < 0.05). Sperm progressive motility (18.1 ± 8.68 vs 24.6 ± 10.2%, p < 0.01) and total motility (28.4 ± 8.71 vs 34.4 ± 11.7%, p < 0.01) also increased significantly following treatment. No change, however, was observed in semen volume or the proportion of sperms with normal morphology. Conclusion: The combination of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 can significantly improve sperm concentration and motility in infertile men with idiopathic oligo asthenozoospermia, which could be attributed to their synergistic antioxidant action.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar¹

2017

International Journal of Infertility &Amp; Fetal Medicine

View full text Add to dashboard Cite

show abstract

“…Coenzyme Q10 (CoQ10), also termed as ubiquinone, is a respiratory chain component and acts as an antioxidant molecule. It is present in the human seminal fluid where it is involved in several antioxidant, mitochondrial bioenergetics and metabolic processes [14]. CoQ10 deficiency can lead to sperm damage, lower sperm motility and sperm count.…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

Alahmar

Calogero

Sengupta

et al. 2021

World J Mens Health

View full text Add to dashboard Cite

Purpose: Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of idiopathic male infertility, in general, owing to its antioxidant properties. Thus, the present study intends to investigate the effects of CoQ10 therapy on semen parameters, oxidative stress markers and SDF in infertile men, specifically with idiopathic oligoasthenozoospermia (OA). Materials and Methods: In this case-control study, sixty-five infertile patients with idiopathic OA and forty fertile men (control) were included. All participants underwent semen analysis based on the World Health Organization guidelines (5th edition, 2010). Patients received CoQ10 at the dose of 200 mg/d orally for three months. Seminal plasma CoQ10, total antioxidant capacity (TAC), total reactive oxygen species (ROS), glutathione peroxidase (GPx), and SDF levels were measured in controls (baseline) and infertile patients pre-and post-CoQ10 treatment. Results: CoQ10 treatment for three months significantly improved sperm concentration (p<0.05), progressive motility (p<0.05), total motility (p<0.01), seminal fluid CoQ10 concentration (p<0.001), TAC (p<0.001), and GPx (p<0.001) levels in infertile men with OA. Further, ROS level (p<0.05) and SDF percentage (p<0.001) were reduced in OA patients as compared to the baseline. CoQ10 levels also correlated positively with sperm concentration (r=0.48, p=0.01) and total motility (r=0.59, p=0.003) while a negative correlation was recorded between SDF and sperm motility (r=-0.54, p=0.006). Conclusions: CoQ10 supplementation for three months could improve semen parameters, oxidative stress markers and reduce SDF in infertile men with idiopathic OA.

show abstract

“…Oxidative stress has been implicated in the development of many diseases, such as cancer, diabetes, cardiovascular disease, rheumatoid arthritis, liver disease, AIDS (acquired immune deficiency syndrome), Parkinson disease, and motor neuron disease [ 4 ]. Reactive oxygen species (ROS) levels have been also linked to male infertility, and studies have reported higher levels of ROS and suppressed antioxidant capacity in the semen of infertile men in comparison to their fertile counterparts [ 5 6 7 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Alahmar

2018

Clin Exp Reprod Med

View full text Add to dashboard Cite

It has been estimated that approximately 15% of reproductive-age couples suffer from infertility. Male factors contribute to almost half of infertility cases, and in many patients the underlying cause of oligoasthenoteratozoospermia is unknown. Accumulating evidence suggests that oxidative stress plays a role as a contributing factor to male infertility, and reactive oxygen species have been shown to impair sperm function and motility and to damage sperm membrane and DNA. Therefore, this review explored the evidence provided by studies published from 2002 to 2017 on the impact of oral antioxidants (vitamin C, vitamin E, L-carnitine, coenzyme Q10, zinc, selenium, and pentoxifylline) on seminal fluid parameters in men with idiopathic oligoasthenoteratozoospermia. Most of the studies were randomized controlled studies that investigated the effect of single or combined antioxidants and reported improvements in at least one semen parameter. The most noteworthy effect that was found was that the use of multiple antioxidants increased sperm motility and concentration. Nonetheless, there is a lack of agreement on the dose, the duration of treatment, and whether individual or combined oral antioxidants should be used. Therefore, the current review provides evidence supporting the use of oral antioxidants in the treatment of infertile men with idiopathic oligoasthenoteratozoospermia.

show abstract

CoQ10 and L-Carnitine Attenuate the Effect of High LDL and Oxidized LDL on Spermatogenesis in Male Rats

Abstract: Overall, pretreatment with coenzyme Q10 and L-Carnitine attenuated the destructive effects of high LDL and oxidized LDL levels on spermatogenesis parameters in male rats.

Cited by 17 publications

References 1 publication

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Contact Info

Product

Resources

About