Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

Alahmar, Ahmed T; Calogero, Aldo E.; Sengupta, Pallav; Dutta, Sulagna

doi:10.5534/wjmh.190145

Cited by 57 publications

(75 citation statements)

References 27 publications

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“…L‐Carnitine and coenzyme Q10 are powerful antioxidants that prevent LPO and SDF. Meta‐analysis and other studies showed that both compounds improved conventional sperm parameters 118‐122 . Several studies on supplementation with a combination of antioxidants have also been reported 123‐125 .…”

Section: Management and Prevention For Mosimentioning

confidence: 89%

“…Meta-analysis and other studies showed that both compounds improved conventional sperm parameters. [118][119][120][121][122] Several studies on supplementation with a combination of antioxidants have also been reported. [123][124][125] These antioxidant therapies and outcomes were shown in possible toxic effect when overused.…”

Section: Shorter Interval Of Ejaculatory Abstinencementioning

confidence: 99%

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Oxidative stress and male infertility

Takeshima

Usui

Mori

et al. 2020

Reprod Medicine & Biology

103

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Infertility is defined by the International Committee for Monitoring Assisted Reproductive Technologies as the incapacity to conceive after at least one year of regular, unprotected, and well-timed intercourse, 1 and has become a global problem faced by one out of five couples. Although approximately 50% of these cases are associated with male infertility, 2 the etiology of male infertility is multifactorial and the average incidence of unexplained male infertility is approximately 15%. 2 Furthermore, approximately 40% of cases were unexplained in a recent survey on infertility among Japan males. 3 Many studies have reportedly revealed the pathophysiologies of unexplained male infertility, but the causes of most cases remain unknown. Many studies on the effect of seminal oxidative stress (OS) on male fertile capacity have been reported since Aitken et al first reported reactive oxygen species (ROS) in washed human semen in 1987 using a chemiluminescence assay. 4 OS results from a disturbance of homeostatic balance between ROS production and antioxidant capacity in seminal plasma in human semen 5 (Figure 1). It is well known that a small amount of ROS is vital for the steps involved in the essential physiological response of fertilization-sperm maturation, hyperactivation, capacitation, acrosome reaction of sperm, and

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Section: Management and Prevention For Mosimentioning

confidence: 89%

Section: Shorter Interval Of Ejaculatory Abstinencementioning

confidence: 99%

Oxidative stress and male infertility

Takeshima

Usui

Mori

et al. 2020

Reprod Medicine & Biology

103

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“…Mercury (217.216 ppm; 800 μΜ) has been reported to significantly (p < 0.001) increase (12.0% compared to 2% in control) percentage of DNA breaks in human sperms 42 . Positive correlation between sperm DNA fragmentation and levels of ROS has been reported in testicular tissue of mice 43 and semen of humans 44,45 . TUNEL assay in the present study revealed that mercuric chloride at lower concentration (0.031 µg/ml) did not induce any DNA damage in sperm cells even after 3 h of exposure.…”

Section: Correlation Between Dna Damage Apoptosis and Necrosis Datamentioning

confidence: 87%

Collapsed mitochondrial cristae in goat spermatozoa due to mercury result in lethality and compromised motility along with altered kinematic patterns

Kushawaha

Yadav

Swain

et al. 2021

Sci Rep

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Earlier we have reported mercury-induced alterations in functional dynamics of buck spermatozoa through free radicals-mediated oxidative stress and spontaneous acrosome reaction. Based on our earlier findings, we aimed to investigate the effect of mercury exposure on motility, kinematic patterns, DNA damage, apoptosis and ultra-structural alterations in goat spermatozoa following in vitro exposure to different concentrations (0.031–1.25 µg/ml) of mercuric chloride for 15 min and 3 h. Following exposure of sperm cells to 0.031 µg/ml of mercuric chloride for 3 h, livability and motility of sperms was significantly reduced along with altered kinematic patterns, significant increase in per cent necrotic sperm cells and number of cells showing DNA damage; and this effect was dose- and time-dependent. Contrary to up-regulation of Bax gene after 3 h in control group, there was significant increase in expression of Bcl-2 in mercury-treated groups. Transmission electron microscopy studies revealed rifts and nicks in plasma and acrosomal membrane, mitochondrial sheath, and collapsed mitochondria with loss of helical organization of mitochondria in the middle piece of spermatozoa. Our findings evidently suggest that mercury induces necrosis instead of apoptosis and targets the membrane, acrosome, mid piece of sperms; and the damage to mitochondria seems to be responsible for alterations in functional and kinematic attributes of spermatozoa.

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“…The authors reported a significant improvement of sperm analysis parameters (sperm concentration, progressive motility and total motility) compared to the baseline levels recorded before the beginning of treatment. Furthermore, CoQ 10 supplementation increased the total antioxidant capacity and the glutathione peroxidase levels, with a consequent reduction in ROS levels and in the sperm DNA fragmentation index [ 188 ]. Similar results concerning the amelioration in sperm concentration, motility, and antioxidant status, were also obtained in the third study, in which 35 infertile males with idiopathic oligoasthenozoospermia were administered 200 mg/day of CoQ 10 H 2 [ 189 ].…”

Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning

confidence: 99%

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

Amorini

Listorti²,

Bilotta³

et al. 2021

Antioxidants

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Under physiological conditions, reactive oxygen species (ROS) play pivotal roles in various processes of human spermatozoa. Indeed, semen requires the intervention of ROS to accomplish different stages of its maturation. However, ROS overproduction is a well-documented phenomenon occurring in the semen of infertile males, potentially causing permanent oxidative damages to a vast number of biological molecules (proteins, nucleic acids, polyunsaturated fatty acids of biological membrane lipids), negatively affecting the functionality and vitality of spermatozoa. ROS overproduction may concomitantly occur to the excess generation of reactive nitrogen species (RNS), leading to oxidative/nitrosative stress and frequently encountered in various human pathologies. Under different conditions of male infertility, very frequently accompanied by morpho-functional anomalies in the sperm analysis, several studies have provided evidence for clear biochemical signs of damages to biomolecules caused by oxidative/nitrosative stress. In the last decades, various studies aimed to verify whether antioxidant-based therapies may be beneficial to treat male infertility have been carried out. This review analyzed the results of the studies published during the last ten years on the administration of low-molecular-weight antioxidants to treat male infertility in order to establish whether there is a sufficient number of data to justify antioxidant administration to infertile males. An analysis of the literature showed that only 30 clinical studies tested the effects of the administration of low-molecular-weight antioxidants (administered as a single antioxidant or as a combination of different antioxidants with the addition of vitamins and/or micronutrients) to infertile males. Of these studies, only 33.3% included pregnancy and/or live birth rates as an outcome measure to determine the effects of the therapy. Of these studies, only 4 were case–control studies, and only 2 of them found improvement of the pregnancy rate in the group of antioxidant-treated patients. Additionally, of the 30 studies considered in this review, only 43.3% were case–control studies, 66.7% enrolled a number of patients higher than 40, and 40% carried out the administration of a single antioxidant. Therefore, it appears that further studies are needed to clearly define the usefulness of antioxidant-based therapies to treat male infertility.

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Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

Cited by 57 publications

References 27 publications

Oxidative stress and male infertility

Oxidative stress and male infertility

Collapsed mitochondrial cristae in goat spermatozoa due to mercury result in lethality and compromised motility along with altered kinematic patterns

Antioxidant-Based Therapies in Male Infertility: Do We Have Sufficient Evidence Supporting Their Effectiveness?

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