Copper, Zinc, and Selenium in Whole Blood and Thyroid Tissue of People with Various Thyroid Diseases

Kucharzewski, Marek; Braziewicz, J.; Majewska, U.; Góźdż, Stanisław

doi:10.1385/bter:93:1-3:9

Cited by 86 publications

(66 citation statements)

References 33 publications

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“…Other authors have estimated the concentration rates of Cu/Zn in the cancerous thyroid tumor were significantly higher than in the normal and other thyroid diseases. 16,17 This study also confirmed that the cancerous thyroid tissues have higher Cu concentrations than the non-cancerous (adenoma) thyroid…”

Section: Determination Of Copper and Zinc In Human Thyroid Tissuessupporting

confidence: 69%

“…Similarly, Kucharzewski et al have observed the lower Zn concentrations in the cancerous thyroid patients than in the other thyroid patients. 17 In another study, 15 Zn concentrations of cancerous and adenoma thyroid tissues were found to be close to each other. We estimated that the concentrations rates of Cu/Zn in cancerous thyroid tissues were significantly higher (p < 0.05) than in the non-cancerous tissues ( Table 2).…”

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confidence: 83%

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Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Yaman

Akdeniz

2004

ANAL. SCI.

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Various designs of quartz tube in a slotted tube atom trap were examined for improving the sensitivity of flame AAS. A 3.5-fold enhancement in the sensitivity was obtained by using the optimized method. The method was applied to the determination of Cu in cancerous and non-cancerous human thyroid tissues. The Cu concentrations of the cancerous samples tended to increase compared with the non-cancerous samples. Zn concentrations of the same tissues were also determined.

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Section: Determination Of Copper and Zinc In Human Thyroid Tissuessupporting

confidence: 69%

mentioning

confidence: 83%

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Yaman

Akdeniz

2004

ANAL. SCI.

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“…Moreover, zinc levels measurements in thyroid tissue together with oxidant/antioxidant balance evaluation could also be of assistance in explaining the mechanism. 27 Finally, thyroid nodules in patients with AITD should also be examined separately to assess the effect of zinc in this group.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation

Ertek¹,

Cicero²,

Çağlar³

et al. 2010

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ObJEcTIVE: Zinc is essential for many biochemical processes and also for cell proliferation. Thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. Additionally, zinc deficiency affects thyroid function. The aim of the present study was to evaluate a possible association of zinc levels with thyroid volume, thyroid hormones and thyroid autoantibody levels in healthy subjects, patients with autoimmune thyroid disease (AITD) and patients with nodular goitre following successful iodine supplementation. This is a cross-sectional study in which 201 subjects who were not under medical treatment and did not have previous thyroid surgery or radio-iodine treatment were evaluated. seventy patients had nodular goitre, 67 AITD and 64 had normal thyroid. Thyroid volume was calculated by ultrasonographic measurements. serum free T4, T3, TsH, anti-thyroglobulin and anti-thyroid peroxidase levels were determined by appropriate methodology.REsULTs: In patients with normal thyroid, zinc levels were significantly positively correlated with free T3 levels (p<0.001). In the nodular goitre group, thyroid volume was negatively correlated with TsH and circulating zinc levels (p=0.014 and p=0.045, respectively). In the AITD group, thyroid autoantibodies and zinc were significantly positively correlated. Multiple regression analysis revealed a significant relationship between thyroid volume and zinc only in the patients with nodular goitre (p=0.043). cONcLUsION: There was significant correlation of serum zinc levels with thyroid volume in nodular goitre patients, with thyroid autoantibodies in AITD and with free T3 in patients with normal thyroid.

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“…Serum Se concentrations do not reflect tissue levels (Kucharzewski et al 2002(Kucharzewski et al , 2003. In fact, intake of a single 200 mg dose of Se can produce adequate serum levels in AIT patients, as in normal individuals (Duntas et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses

Türker¹,

Kumanlıoğlu²,

Karapolat³

et al. 2006

Journal of Endocrinology

132

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The aim of this study is to investigate the long-term (9 months) effects of variable doses (200/100 mg/day) of L-selenomethionine on autoimmune thyroiditis (AIT) and the parameters affecting the success rate of this therapy. The present study was designed in three steps: (1) 88 female patients with AIT (mean ageZ40$1G13$3 years) were randomized into two groups according to their initial serum TSH, thyroid peroxidase antibody (TPOAb) concentrations, and age. All the patients were receiving L-thyroxine to keep serum TSH%2 mIU/l. Group S2 (nZ48, mean TPOAbZ803$9G483$8 IU/ml) received 200 mg L-selenomethionine per day, orally for 3 months, and group C (nZ40, mean TPOAbZ770$3G 406$2 IU/ml) received placebo. (2) 40 volunteers of group S2 were randomized into two age-and TPOAb-matched groups. Group S22 (nZ20) went on taking L-selenomethionine 200 mg/day, while others (group S21) lowered the dose to 100 mg/day. (3) 12 patients of group S22 (group S222) went on taking L-selenomethionine 200 mg/day, while 12 patients of group S21 (S212) increased the dose to 200 mg/day. Serum titers of TPOAb decreased significantly in group S2 (26$2%, P!0$001), group S22 (23$7%, P!0$01) and group S212 (30$3%, P!0$01). There were no significant changes in group C and group S222 (PO0$05). TPOAb titers increased significantly in group S21 (38$1%, P!0$01). A significant decrease in thyroglobulin antibody titers was only noted in group S2 (5$2%, P!0$01). L-selenomethionine substitution suppresses serum concentrations of TPOAb in patients with AIT, but suppression requires doses higher than 100 mg/day which is sufficient to maximize glutathione peroxidase activities. The suppression rate decreases with time.

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Copper, Zinc, and Selenium in Whole Blood and Thyroid Tissue of People with Various Thyroid Diseases

Cited by 86 publications

References 33 publications

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation

Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses

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