Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses

Türker, Ömer; Kumanlıoğlu, Kamil; Karapolat, İnanç; Doğan, İsmail

doi:10.1677/joe.1.06661

Cited by 133 publications

(114 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the interaction is modest when subjects are not sufficiently iodine and/or selenium deficient (16,19). Beneficial effects of selenium supplementation on autoimmune thyroiditis have been reported, possibly through the action of GPx in enhancing the immune system and protecting the thyroid gland against oxidant stress (30)(31)(32). In a recent randomized controlled trial with patients with autoimmune thyroiditis, physiological doses of selenium improved thyroid structure and reduced autoantibody titer (33).…”

Section: Discussionmentioning

confidence: 99%

Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders

Thomson

Campbell²,

Miller³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status. Methods: In a randomized controlled trial on older people (meanGS.D. 73G4.8 years; nZ143), two groups received O50 mg iodine as iodate/day for 8 weeks because of supplement formulation error, either with 100 mg selenium (SeChighI) or without selenium (highI). Four other groups received 80 mg iodine as iodate/day with selenium (SeClowI) or without selenium (lowI), selenium alone (SeC), or placebo. Thyroid hormones, selenium status, and median urinary iodine concentration (MUIC) were compared at weeks 0, 8, and 4 weeks post-supplementation. Results: MUIC increased nine-and six-fold in SeChighI and highI groups, decreasing to baseline by week 12. Plasma selenium increased in selenium-supplemented groups (P!0.001). The level of increase in whole blood glutathione peroxidase (WBGPx) in the SeChighI group was smaller than SeC (PZ0.020) and SeClowI (PZ0.007) groups. The decrease in WBGPX in the highI group was greater than other non-selenium-supplemented groups, but differences were not significant. Ten of 43 participants exposed to excess iodate showed elevated TSH (hypothyroidism) at week 8. In all but two, TSH had returned to normal by week 12. In three participants, TSH decreased to !0.10 mIU/l (hyperthyroidism) at week 8, remaining low at week 12. Conclusions: Excess iodate induced hypothyroidism in some participants and hyperthyroidism in others. Most abnormalities disappeared after 4 weeks. Excess iodate reduced WBGPx activity and resulted in smaller increases in WBGPx after selenium supplementation.

show abstract

Section: Discussionmentioning

confidence: 99%

Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders

Thomson

Campbell²,

Miller³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…It has thus been hypothesized that even mild nutritional selenium deficiency may promote the initiation or progression of thyroid autoimmunity. To test the hypothesis that selenium supplementation decreases the serum concentration of TPO-Ab, six randomized clinical trials have been performed (55,56,57,58,59,60).…”

Section: Seleniummentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players

Effraimidis

Wiersinga

2014

European Journal of Endocrinology

284

196

View full text Add to dashboard Cite

The last 10 years have seen some progress in understanding the etiology of autoimmune thyroid disease (AITD). The female preponderance can now be explained -at least in part -by fetal microchimerism and X-chromosome inactivation. The number of identified susceptibility genes for AITD is increasing (among others now including TSHR, TG, HLA, CTLA4, PTPN22, CD40, FCRL3, IL2RA, and FOXP3), but these genes together probably do not explain more than about 10% of the heritability of AITD. As twin studies indicate that genes contribute for 70% of AITD, it follows that there must be many more loci, each of them contributing a little. While the genetic studies have clarified why various autoimmune diseases so often cluster in the same patient, the molecular mechanism of action of these genetic polymorphisms (frequently located in introns) has hardly been explained. Polymorphisms in AITD susceptibility genes may become helpful in clinical practice, e.g. in assessing risk of recurrent Graves' hyperthyroidism (GH) after a course of antithyroid drugs. Moderate alcohol intake decreases the risk on overt GH and overt Hashimoto's hypothyroidism. Current smokers -as well known -are at increased risk for Graves' disease, but -surprisingly -at diminished risk for Hashimoto's thyroiditis. Low selenium and low vitamin D levels might increase the risk of developing AITD, but data are still inconclusive. Current options for preventive interventions in subjects at risk to develop AITD are very limited.

show abstract

“…In addition, based on the data from two studies, the beneficial effect of selenium supplementation was confirmed regarding the mood of the patients [126]. Brief characteristics of the most important prospective clinical studies [98,122,[127][128][129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144] concerning the efficacy of supplementation with selenium in benign thyroid diseases, in particular autoimmune diseases, are presented in Table II.…”

Section: ) Short Characteristics Of the Most Important Clinical Trimentioning

confidence: 99%

The role of selenium in thyroid gland pathophysiology

Stuss¹,

Michalska-Kasiczak

Sewerynek³

2017

Endokrynologia Polska

View full text Add to dashboard Cite

It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG. This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

show abstract

Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses

Cited by 133 publications

References 21 publications

Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders

Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders

MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players

The role of selenium in thyroid gland pathophysiology

Contact Info

Product

Resources

About