Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Yaman, Mehmet; Akdeniz, Ismail

doi:10.2116/analsci.20.1363

Cited by 37 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uda et al observed that the defi ciency or excess of trace elements concentrations in cancerous tissues of different organs may be different (11). In the literature, it is described that trace element concentrations of healthy adult thyroid glands were not dependent on sex or age (12). In our series all of the patients and healthy controls were females and there was no statistical difference between the groups (p>0.05).…”

Section: Discussionmentioning

confidence: 38%

“…In opposite to our results Reddy et al (16) have reported lower levels of Cu in the tissue of cancerous thyroid than in normal thyroid tissue and like our results (our results are refl ecting serum levels), much lower levels of Cu in the tissue of thyroid adenoma. Other authors have estimated the concentration rates of Cu/Zn in the cancerous thyroid tumour were signifi cantly higher than in the normal and other thyroid disease (12,17,18).…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

View full text Add to dashboard Cite

Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

show abstract

Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 93%

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

View full text Add to dashboard Cite

show abstract

“…Small amount of copper is found in the human body (50-120 mg), but it plays a critical role in a variety of biochemical processes (Yaman and Akdeniz 2004). Copper forms part of at least 13 different enzymes, and its presence is It is known that copper may be toxic to both humans and animals when its concentration exceeds the safe limits (Gast et al 1988).…”

Section: Resultsmentioning

confidence: 99%

Assessment of heavy metals in some wild edible mushrooms collected from Yunnan Province, China

Zhu

Fan

et al. 2010

Environ Monit Assess

145

View full text Add to dashboard Cite

Eight heavy metals (Cu, Zn, Fe, Mn, Cd, Cr, Ni, and Pb) in 14 different wild-growing edible mushroom species (Coprinus comatus, Voluariella volvacea, Pleurotus nebrodensis, Hypsizigus marmoreus, Hericium erinaceus, Agrocybe aegerita, Lenfinus edodes, Collybia velutipes, Agaricus bisporus, Russula albida, Clitocybe conglobata, Pleurotus eryngii, Lepista sordida, and Pleurotus ostreatus) collected from Yunnan province, China, were determined by inductively coupled plasma-atomic emission spectrometry after microwave digestion. All element concentrations were determined on a dry weight basis. The ranges of element concentrations for copper, zinc, iron, manganese, cadmium, chromium, nickel, and lead were 6.8-31.9, 42.9-94.3, 67.5-843, 13.5-113, 0.06-0.58, 10.7-42.7, 0.76-5.1, and 0.67-12.9 mg/kg, respectively. In general, iron content was higher than other metals in all mushroom species. The levels of zinc, cadmium, and lead in some edible mushroom samples were found to be higher than legal limits. The relative standard deviations were found below 10%. The accuracy of procedure was confirmed by certified reference material.

show abstract

“…However, skeletal and reproductive effects are also discussed as possible critical effects (Nordberg 2003). Also, it is known that Cu is essential element yet it may be toxic to both humans and animals when its concentration exceeds the safe limits and its concentration in some human tissues such as thyroid can be change dependent on the tissue state including cancerous or non-cancerous (Yang et al 2002;Yaman and Akdeniz 2004). Obviously, the monitoring of lead, cadmium and copper levels in the environment has a high importance.…”

Section: Introductionmentioning

confidence: 99%

Determination of lead, cadmium and copper in roadside soil and plants in Elazig, Turkey

Bakırdere

Yaman

2007

Environ Monit Assess

Self Cite

127

View full text Add to dashboard Cite

The concentrations of lead, cadmium and copper in roadside soil and plants in Elazig, Turkey were investigated. Soil samples were collected at distances of 0, 25 and 50 m from the roadside. The concentrations of lead, cadmium and copper were measured by Flame Atomic Absorption Spectrophotometry (FAAS). A slotted tube atom trap (STAT) was used to increase the sensitivity of lead and cadmium in FAAS. Lead concentrations in soil samples varied from 1.3 to 45 mg kg(-1) while mean lead levels in plants ranged from120 ng g(-1) for grape in point-4 to 866 ng g(-1) for apple leaves in point-2. Lead analyses showed that there was a considerable contamination in both soil and plants affected from traffic intensity. Overall level of Cd in soil samples lies between 78 and 527 ng/g while cadmium concentration in different vegetations varied in the range of 0.8-98.0 ng g(-1). Concentrations of copper in soil and plant samples were found in the range of 11.1-27.9 mg kg(-1) for soil and 0.8-5.6 mg kg(-1) for plants. Standard reference material (SRM) was used to find the accuracy of the results of soil analyses.

show abstract

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Cited by 37 publications

References 16 publications

Serum copper levels in benign and malignant thyroid diseases

Serum copper levels in benign and malignant thyroid diseases

Assessment of heavy metals in some wild edible mushrooms collected from Yunnan Province, China

Determination of lead, cadmium and copper in roadside soil and plants in Elazig, Turkey

Contact Info

Product

Resources

About